INT36053

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Context Info
Confidence 0.70
First Reported 1988
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 22
Total Number 22
Disease Relevance 11.41
Pain Relevance 6.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
joint 2
chondrocytes 2
macrophages 2
monocytes 2
alveolar macrophages 2
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 172 100.00 Very High Very High Very High
cytokine 123 100.00 Very High Very High Very High
chemokine 61 100.00 Very High Very High Very High
rheumatoid arthritis 58 100.00 Very High Very High Very High
cINOD 14 100.00 Very High Very High Very High
Inflammatory stimuli 4 100.00 Very High Very High Very High
agonist 25 99.98 Very High Very High Very High
bradykinin 13 99.98 Very High Very High Very High
antagonist 24 99.60 Very High Very High Very High
dexamethasone 7 96.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 209 100.00 Very High Very High Very High
Rheumatoid Arthritis 62 100.00 Very High Very High Very High
Necrosis 18 100.00 Very High Very High Very High
Cancer 18 100.00 Very High Very High Very High
Infection 28 98.56 Very High Very High Very High
Sarcoidosis 8 98.38 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 12 98.16 Very High Very High Very High
Synovitis 3 97.78 Very High Very High Very High
Acute-phase Reaction 2 95.92 Very High Very High Very High
Syndrome 71 91.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Comparing normal alveolar macrophages to those from patients with sarcoidosis showed no differences in the kinetics of IL1-beta mRNA expression or in the LPS-induced levels of IL1-beta mRNA accumulation.
Positive_regulation (induced) of Positive_regulation (accumulation) of IL1-beta in alveolar macrophages associated with sarcoidosis
1) Confidence 0.70 Published 1988 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 3264123 Disease Relevance 0.66 Pain Relevance 0.10
Escherichia coli lipopolysaccharide stimulation of monocytes induced rapid IL1-beta mRNA accumulation, reaching a maximum at 2 to 4 h and declining thereafter.
Positive_regulation (induced) of Positive_regulation (accumulation) of IL1-beta in monocytes
2) Confidence 0.70 Published 1988 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 3264123 Disease Relevance 0.14 Pain Relevance 0.08
However, the circulating concentration of IL-1?
Positive_regulation (circulating) of Positive_regulation (concentration) of IL-1
3) Confidence 0.49 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.61 Pain Relevance 0.23
RESULTS: Before therapy we could detect significantly higher serum levels of IL-1beta and TNF-alpha (P < 0.001) and of circulating adhesion molecules in comparison with controls (sELAM, sICAM: P < 0.001; sVCAM: P < 0.02); after treatment, a significant reduction of each was observed (P < 0.05).
Positive_regulation (detect) of Positive_regulation (levels) of IL-1beta
4) Confidence 0.49 Published 2002 Journal Int. J. Dermatol. Section Body Doc Link 12121561 Disease Relevance 0.14 Pain Relevance 0
These effects are mediated in part by induction of downstream inflammatory cytokines and chemokines, especially IL-1beta, IL-18, and leptin.
Positive_regulation (mediated) of Positive_regulation (induction) of IL-1beta associated with chemokine, inflammation and cytokine
5) Confidence 0.49 Published 2010 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 20543002 Disease Relevance 0.73 Pain Relevance 0.38
Caspase-1, the IL-1beta converting enzyme (ICE), is required for intracellular processing/maturation of IL-1beta and IL-18.
Positive_regulation (required) of Positive_regulation (processing/maturation) of IL-1beta
6) Confidence 0.49 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.25 Pain Relevance 0.31
Incubation of LT4 and ECV304 cells with interleukin-1beta or TNF-alpha produced a significant increase in ICAM-1 expression on their cell surface (ranging from a 2-fold increase for interleukin-1beta to a 5-fold increase for TNF-alpha).
Positive_regulation (ranging) of Positive_regulation (increase) of interleukin-1beta in ECV304
7) Confidence 0.49 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274931 Disease Relevance 0.42 Pain Relevance 0.52
Although both desArg(10)KD and BK increased the level of IL-1beta mRNA, IL-1beta receptor antagonist inhibited the increase in B1R only in response to BK.
Positive_regulation (increased) of Positive_regulation (increased) of IL-1beta associated with antagonist and bradykinin
8) Confidence 0.49 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10419551 Disease Relevance 0.22 Pain Relevance 0.84
Our work has shown that in degenerate discs there is an increase in IL-1, but no corresponding increase in the inhibitor IL-1 receptor antagonist.
Positive_regulation (increase) of Neg (no) Positive_regulation (increase) of IL-1 associated with antagonist
9) Confidence 0.47 Published 2007 Journal Biochem. Soc. Trans. Section Abstract Doc Link 17635113 Disease Relevance 0.32 Pain Relevance 0.24
Interestingly, the IL1B induced increase in TRPC3 expression does not appear to be influenced by PTGS2 mediated prostaglandin synthesis, as nimesulide (a PTGS2 specific inhibitor) does not inhibit the response [26].
Positive_regulation (induced) of Positive_regulation (increase) of IL1B
10) Confidence 0.46 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892065 Disease Relevance 0.05 Pain Relevance 0.11
The impact-loading induced the expression of IL-1beta immunohistochemically and prominently up-regulated IL-1alpha and IL-1beta mRNA levels in subchondral bone.
Positive_regulation (induced) of Positive_regulation (up-regulated) of IL-1beta
11) Confidence 0.45 Published 2009 Journal Ann Biomed Eng Section Abstract Doc Link 19381811 Disease Relevance 0.36 Pain Relevance 0.26
Komuro et al. [4] reported that OPG expression in chondrocytes increased in response to IL-1?
Positive_regulation (increased) of Positive_regulation (response) of IL-1 in chondrocytes
12) Confidence 0.43 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.18 Pain Relevance 0.09
These culture supernatants showed elevated levels of interleukin-1 beta, IL-6 and tumor necrosis factor alpha.
Positive_regulation (levels) of Positive_regulation (elevated) of interleukin-1 beta associated with necrosis and cancer
13) Confidence 0.21 Published 1995 Journal J. Neuroimmunol. Section Abstract Doc Link 7560019 Disease Relevance 0.73 Pain Relevance 0.25
These culture supernatants showed elevated levels of interleukin-1 beta, IL-6 and tumor necrosis factor alpha.
Positive_regulation (elevated) of Positive_regulation (levels) of interleukin-1 beta associated with necrosis and cancer
14) Confidence 0.21 Published 1995 Journal J. Neuroimmunol. Section Abstract Doc Link 7560019 Disease Relevance 0.73 Pain Relevance 0.25
The cryopyrin protein contains an N-terminal pyrin domain and has an important role in regulation of the assembly of the inflammasome, a group of proteins that when assembled activate caspase-1 that cleaves pro IL-1?
Positive_regulation (cleaves) of Positive_regulation (pro) of IL-1
15) Confidence 0.13 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880341 Disease Relevance 1.47 Pain Relevance 0.26
Protamine blocked the heparin-induced increase in tumour necrosis factor alpha and interleukin-1 beta.
Positive_regulation (heparin-induced) of Positive_regulation (increase) of interleukin-1 beta associated with necrosis and cancer
16) Confidence 0.08 Published 1996 Journal Anaesthesia Section Abstract Doc Link 8758154 Disease Relevance 0.71 Pain Relevance 0.37
TLR agonists induced P2X7 receptor-dependent IL-1?
Positive_regulation (induced) of Positive_regulation (dependent) of IL-1 associated with agonist
17) Confidence 0.08 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2906308 Disease Relevance 0.08 Pain Relevance 0.21
After these results, 123I-IL-1 RA was studied in patients with rheumatoid arthritis (RA) and to assess whether it is suitable for scintigraphic visualization of synovitis . 123I-IL-1 RA was able to image inflamed joints but autoradiographic studies did not indicate that the joint accumulation of radiolabelled IL-1 RA was due to specific IL-1 receptor targeting [139].
Positive_regulation (due) of Positive_regulation (accumulation) of IL-1 in joint associated with synovitis and rheumatoid arthritis
18) Confidence 0.07 Published 2010 Journal Eur J Nucl Med Mol Imaging Section Body Doc Link PMC2975909 Disease Relevance 1.80 Pain Relevance 0.63
B is activated rapidly in response to inflammatory stimuli such as IL-1?
Positive_regulation (activated) of Positive_regulation (response) of IL-1 associated with inflammatory stimuli
19) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582805 Disease Relevance 0.31 Pain Relevance 0.16
IL-8 is expressed by macrophages and released after inflammatory stimuli in response to the primary cytokines IL-1?
Positive_regulation (stimuli) of Positive_regulation (response) of IL-1 in macrophages associated with cytokine and inflammatory stimuli
20) Confidence 0.04 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC212422 Disease Relevance 0.68 Pain Relevance 0.53

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