INT36055

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Context Info
Confidence 0.49
First Reported 1988
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 6.24
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
osteoblasts 2
brain 2
alveolar macrophages 2
gut 2
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
spastic colon 10 99.92 Very High Very High Very High
Inflammatory mediators 16 96.24 Very High Very High Very High
cINOD 3 90.08 High High
Inflammation 96 89.68 High High
Inflammatory response 12 89.68 High High
cytokine 61 88.40 High High
depression 2 80.16 Quite High
Snapping jaw 4 60.36 Quite High
Osteoarthritis 4 58.88 Quite High
lidocaine 1 57.00 Quite High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

8 99.92 Very High Very High Very High
Cerebral Malaria 51 99.40 Very High Very High Very High
Sarcoidosis 4 98.28 Very High Very High Very High
Cancer 24 96.28 Very High Very High Very High
INFLAMMATION 132 95.84 Very High Very High Very High
Malaria 23 95.04 Very High Very High Very High
Pituitary Cancer 4 94.56 High High
Anaplastic Astrocytoma 3 92.56 High High
Gastroenteritis 3 88.52 High High
Disease 39 85.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The hormone also attenuated TNF-alpha-dependent mRNA expression of IL-1beta.
Positive_regulation (attenuated) of Transcription (expression) of IL-1beta
1) Confidence 0.49 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17525069 Disease Relevance 0.45 Pain Relevance 0.24
We confirmed a significant decrease in type II collagen and aggrecan mRNA expressions in chondrocytes by co-culture with osteoblasts after impact-loading, and significant increase in mRNA and protein expressions of IL-1beta in subchondral osteoblasts from impact-loaded subchondral bone.
Positive_regulation (increase) of Transcription (expressions) of IL-1beta in osteoblasts
2) Confidence 0.49 Published 2009 Journal Ann Biomed Eng Section Abstract Doc Link 19381811 Disease Relevance 0.36 Pain Relevance 0.31
In addition, augmented levels of IL1-beta transcript were not noted in unstimulated sarcoid alveolar macrophages.
Positive_regulation (augmented) of Transcription (levels) of IL1-beta in alveolar macrophages associated with sarcoidosis
3) Confidence 0.47 Published 1988 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 3264123 Disease Relevance 0.74 Pain Relevance 0.10
If the increased expression of IL-1B observed in brain of cerebral malaria patients [2,3] is due to the increased transcription of IL1B caused by the IL1B -31T allele [11], the frequency of IL1B -31T should be higher in cerebral malaria patients than in mild malaria patients.
Positive_regulation (increased) of Transcription (transcription) of IL1B in brain associated with malaria and cerebral malaria
4) Confidence 0.47 Published 2005 Journal Malar J Section Body Doc Link PMC1224865 Disease Relevance 0.83 Pain Relevance 0
Interleukin-1beta mRNA levels are increased in the mucosa of those who develop PI-IBS, who also show increased gut permeability.
Positive_regulation (increased) of Transcription (levels) of Interleukin-1beta in gut associated with spastic colon
5) Confidence 0.45 Published 2007 Journal J. Gastroenterol. Section Abstract Doc Link 17238025 Disease Relevance 0.91 Pain Relevance 0.92
Furthermore, PGE2 potentiated IL-1 beta-induced IL-6 mRNA synthesis.
Positive_regulation (induced) of Transcription (synthesis) of IL-1
6) Confidence 0.28 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9003059 Disease Relevance 0.65 Pain Relevance 0.29
Furthermore, PGE2 potentiated IL-1 beta-induced IL-6 mRNA synthesis.
Positive_regulation (induced) of Transcription (synthesis) of IL-1
7) Confidence 0.27 Published 1998 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 9850935 Disease Relevance 0.72 Pain Relevance 0.15
In addition, we observed a significant increase in mRNA expression for genes encoding IL-1?
Positive_regulation (increase) of Transcription (expression) of IL-1
8) Confidence 0.05 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374451 Disease Relevance 0.35 Pain Relevance 0.17
Bacterial LPS induce a 12- to 16-fold increase in IL-1 beta, IL-6, and TNF-alpha mRNA levels.
Positive_regulation (increase) of Transcription (levels) of IL-1
9) Confidence 0.02 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.57 Pain Relevance 0.03

General Comments

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