INT36060

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Context Info
Confidence 0.83
First Reported 1988
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.15
Pain Relevance 0.22

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peptidase activity (Ctsl1) extracellular region (Ctsl1) histone binding (Ctsl1)
vacuole (Ctsl1) lysosome (Ctsl1) cytoplasm (Ctsl1)
Ctsl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 1 99.68 Very High Very High Very High
Spinal cord 1 94.00 High High
anesthesia 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 1 80.32 Quite High
Neurologic Manifestations 1 66.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Anecdotal reports suggest that MEP responses degrade or "fade" over the duration of a surgery, despite unchanged anesthetic levels or other physiologic variables.
Neg (unchanged) Protein_catabolism (degrade) of MEP
1) Confidence 0.83 Published 2005 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 15632537 Disease Relevance 0.07 Pain Relevance 0.12
The higher-molecular-weight CPI potently inhibited cathepsin L hydrolysis of Leu-enkephalin at the Gly2-Gly3 bond with a Ki 10(-10) M.
Protein_catabolism (hydrolysis) of cathepsin L associated with enkephalin
2) Confidence 0.25 Published 1988 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 3265047 Disease Relevance 0.08 Pain Relevance 0.10

General Comments

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