INT36064

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Context Info
Confidence 0.47
First Reported 1985
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 16.38
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CST3) extracellular region (CST3) endoplasmic reticulum (CST3)
lysosome (CST3) cytoplasm (CST3)
Anatomy Link Frequency
heart 3
kidney 1
CST3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 23 97.92 Very High Very High Very High
Inflammation 31 97.12 Very High Very High Very High
Enkephalin 1 94.56 High High
Inflammatory marker 2 83.20 Quite High
Pain 14 80.44 Quite High
cytokine 6 62.32 Quite High
cva 6 43.96 Quite Low
Fibrositis 24 5.00 Very Low Very Low Very Low
Central nervous system 16 5.00 Very Low Very Low Very Low
diabetic neuropathy 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 330 100.00 Very High Very High Very High
Renal Disease 140 100.00 Very High Very High Very High
Cardiovascular Disease 124 100.00 Very High Very High Very High
Myocardial Infarction 50 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 9 99.70 Very High Very High Very High
Obesity 6 99.12 Very High Very High Very High
Infection 2 99.12 Very High Very High Very High
Hypertension 35 99.02 Very High Very High Very High
Nicotine Addiction 2 98.74 Very High Very High Very High
Diabetes Mellitus 180 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, a study in elderly patients without chronic renal disease showed that serum cystatin C was associated with the risk of total mortality, cardiovascular disease mortality, myocardial infarction and stroke [21].
cystatin C Binding (associated) of associated with stroke, cardiovascular disease, renal disease and myocardial infarction
1) Confidence 0.47 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883357 Disease Relevance 1.58 Pain Relevance 0
The association of plasma cystatin-C with the incidence of myocardial infarction-coronary death and angina, was examined in a nested case-control (two controls per case) design within the prospective cohort study (Prospective Epidemiological Study of Myocardial Infarction (PRIME Study)) which included 9,758 men aged 50-59 years who were free of coronary heart disease (CHD) on entry and followed for a 5-year period.
cystatin-C Spec (examined) Binding (association) of in heart associated with angina, coronary artery disease, death and myocardial infarction
2) Confidence 0.47 Published 2006 Journal Atherosclerosis Section Abstract Doc Link 16046222 Disease Relevance 1.03 Pain Relevance 0.16
Serum cystatin C in patients with CAD is associated with total mortality, cardiovascular events and heart failure [20], and was also found to be associated with total mortality in a follow up study of patients with acute coronary syndrome [13].
cystatin C Binding (associated) of in heart associated with acute coronary syndrome, coronary artery disease and myocardial infarction
3) Confidence 0.47 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883357 Disease Relevance 1.50 Pain Relevance 0
In contrast the low-molecular-weight CPIs were present in postmicrosomal fractions (S3) and cross-reacted with anti-cystatin c, but not with anti-HRG, anti-lysozyme, anti-beta protein amyloid peptide, or anti-T-kininogen.
cystatin c Binding (cross-reacted) of associated with alzheimer's dementia
4) Confidence 0.36 Published 1988 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 3265047 Disease Relevance 0.10 Pain Relevance 0.09
Serum cystatin C in patients with CAD is associated with total mortality, cardiovascular events and heart failure [20], and was also found to be associated with total mortality in a follow up study of patients with acute coronary syndrome [13].
cystatin C Binding (associated) of in heart associated with acute coronary syndrome, coronary artery disease and myocardial infarction
5) Confidence 0.36 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883357 Disease Relevance 1.34 Pain Relevance 0
Serum cystatin C levels in patients with chronic renal disease are associated with cardiovascular disease mortality and all cause mortality [19], and were shown to predict cardiovascular death, myocardial infarction and stroke in a prospective cohort of adults aged ?
cystatin C Binding (associated) of associated with stroke, cardiovascular disease, renal disease, myocardial infarction and death
6) Confidence 0.36 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883357 Disease Relevance 1.11 Pain Relevance 0
Complexes of cystatin C or Ig ?
cystatin C Binding (Complexes) of
7) Confidence 0.36 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 0.93 Pain Relevance 0
Previous studies indicated that serum cystatin C, a marker of renal function, was associated with cardiovascular disease (CVD).
cystatin C Binding (associated) of associated with cardiovascular disease
8) Confidence 0.36 Published 2008 Journal Am. J. Cardiol. Section Abstract Doc Link 18572035 Disease Relevance 0.89 Pain Relevance 0.06
In conclusion, a graded association exists between higher serum cystatin C and increased CVD prevalence in patients without established chronic kidney disease.
cystatin C Binding (association) of in kidney associated with chronic renal failure and cardiovascular disease
9) Confidence 0.36 Published 2008 Journal Am. J. Cardiol. Section Abstract Doc Link 18572035 Disease Relevance 1.47 Pain Relevance 0.24
0.0067, respectively) and the association with cystatin C replicated for the CST3-CST9 SNP but not the STC1 SNP (P?
cystatin C Binding (association) of
10) Confidence 0.36 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912386 Disease Relevance 0.25 Pain Relevance 0
However, as stated above, this result also did not show a direct association with cardiovascular disease and cystatin C.
cystatin C Neg (not) Binding (association) of associated with cardiovascular disease
11) Confidence 0.35 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883357 Disease Relevance 1.40 Pain Relevance 0.09
After adjustment for traditional risk factors (age, diabetes, smoking, hypertension, BMI, triglycerides, LDL- and HDL-cholesterol), cystatin-C was significantly associated with the occurrence of the first ischemic coronary event.
cystatin-C Binding (associated) of associated with nicotine addiction, diabetes mellitus, obesity, hypertension and disorder of lipid metabolism
12) Confidence 0.35 Published 2006 Journal Atherosclerosis Section Abstract Doc Link 16046222 Disease Relevance 1.95 Pain Relevance 0.21
However, depending on the association of serum cystatin C and hsCRP levels, cystatin C level was suggested to be associated with inflammation [12,23].
cystatin C Binding (association) of associated with inflammation
13) Confidence 0.35 Published 2010 Journal Korean Diabetes Journal Section Body Doc Link PMC2883357 Disease Relevance 1.44 Pain Relevance 0.09
[Treatment with combination of antibiotics and human gamma-globulin (SM-4300) for severe infection in surgery].
gamma-globulin Binding ([Treatment) of associated with infection
14) Confidence 0.32 Published 1985 Journal Jpn J Antibiot Section Title Doc Link 4079030 Disease Relevance 0.70 Pain Relevance 0.08
[Treatment with combination of antibiotics and human gamma-globulin (SM-4300) for severe infection in surgery].
gamma-globulin Binding (combination) of associated with infection
15) Confidence 0.32 Published 1985 Journal Jpn J Antibiot Section Title Doc Link 4079030 Disease Relevance 0.70 Pain Relevance 0.08

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