INT3607

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Context Info
Confidence 0.59
First Reported 1976
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.17
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cbr1) oxidoreductase activity (Cbr1) plasma membrane (Cbr1)
nucleus (Cbr1) cytoplasm (Cbr1)
Anatomy Link Frequency
plasma 1
microglia 1
Cbr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 10 100.00 Very High Very High Very High
aspirin 9 99.84 Very High Very High Very High
Analgesic 5 98.04 Very High Very High Very High
Inflammation 28 97.66 Very High Very High Very High
Cannabinoid 6 97.44 Very High Very High Very High
analgesia 2 90.80 High High
Hyperalgesia 1 87.68 High High
Arthritis 1 84.60 Quite High
Regional anesthesia 1 76.68 Quite High
Cannabinoid receptor 6 50.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 31 100.00 Very High Very High Very High
Hyperalgesia 2 87.68 High High
Muscle Weakness 1 85.92 High High
Arthritis 1 84.60 Quite High
Pleurisy 1 75.32 Quite High
Tachycardia 1 74.52 Quite High
Nervous System Injury 9 5.00 Very Low Very Low Very Low
Neuropathic Pain 7 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Hypersensitivity 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism responsible for the potentiated anti-inflammatory and mild analgesic activity of aspirin remains unknown since caffeine did not alter the plasma salicylate levels or prostaglandin synthetase inhibition produced by aspirin.
Gene_expression (produced) of prostaglandin synthetase in plasma associated with aspirin, inflammation and analgesic
1) Confidence 0.59 Published 1976 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 815913 Disease Relevance 0.73 Pain Relevance 1.06
Resolution of etodolac and antiinflammatory and prostaglandin synthetase inhibiting properties of the enantiomers.
Gene_expression (Resolution) of prostaglandin synthetase associated with inflammation
2) Confidence 0.58 Published 1983 Journal J. Med. Chem. Section Title Doc Link 6227748 Disease Relevance 0.28 Pain Relevance 0.14
These data suggest that central command was a primary mechanism in the resetting of the CBR during exercise.
Gene_expression (resetting) of CBR
3) Confidence 0.57 Published 2001 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 11247774 Disease Relevance 0.16 Pain Relevance 0.08
The selective CBR2 antagonist, AM630, but not the CBR1 antagonist, AM281, significantly blocked the JWH015-induced MKP-3 in LPS stimulated microglia (1.12 ± 0.02 vs. 1.05 ± 0.02 of LPS alone group, LPS + JWH015 1 ?
Gene_expression (antagonist) of CBR1 in microglia associated with antagonist
4) Confidence 0.08 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0 Pain Relevance 0.20

General Comments

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