INT3608

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Context Info
Confidence 0.45
First Reported 1976
Last Reported 1985
Negated 2
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 2.28
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cbr1) oxidoreductase activity (Cbr1) plasma membrane (Cbr1)
nucleus (Cbr1) cytoplasm (Cbr1)
Anatomy Link Frequency
plasma 1
Cbr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Analgesic 4 99.24 Very High Very High Very High
aspirin 9 99.20 Very High Very High Very High
Inflammation 7 98.42 Very High Very High Very High
Morphine 9 98.40 Very High Very High Very High
analgesia 2 92.32 High High
anesthesia 1 90.64 High High
Hyperalgesia 1 89.20 High High
Dismenorea 2 88.32 High High
Paracetamol 4 78.12 Quite High
depression 2 65.52 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 6 98.42 Very High Very High Very High
Convulsion 5 97.88 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 3 89.76 High High
Hyperalgesia 2 89.20 High High
Fever 2 88.92 High High
Reprotox - General 1 2 88.32 High High
Ulcers 1 85.08 High High
Epilepsy 1 83.64 Quite High
Hypothermia 2 81.56 Quite High
Catalepsy 2 78.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that prostaglandin synthetase inhibitors do not influence the estrogen response mechanism in rodents.
Neg (not) Regulation (influence) of prostaglandin synthetase
1) Confidence 0.45 Published 1983 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 6401395 Disease Relevance 0.07 Pain Relevance 0.07
The mechanism responsible for the potentiated anti-inflammatory and mild analgesic activity of aspirin remains unknown since caffeine did not alter the plasma salicylate levels or prostaglandin synthetase inhibition produced by aspirin.
Neg (not) Regulation (alter) of prostaglandin synthetase in plasma associated with aspirin, inflammation and analgesic
2) Confidence 0.45 Published 1976 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 815913 Disease Relevance 0.74 Pain Relevance 1.08
Since prostaglandins are known to vary with the menstrual cycle in women, implicating an effect associated with sex steroid hormones, we examined the influence of certain prostaglandin synthetase inhibitors on specific estrogen binding capacity of uteri from rats.
Spec (examined) Regulation (influence) of prostaglandin synthetase
3) Confidence 0.39 Published 1983 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 6401395 Disease Relevance 0.09 Pain Relevance 0.09
Differential effects of prostaglandin synthetase inhibitors on EEG in rat.
Regulation (effects) of prostaglandin
4) Confidence 0.31 Published 1985 Journal Eur. J. Pharmacol. Section Title Doc Link 3926513 Disease Relevance 0.08 Pain Relevance 0.08
We also studied the effect of the prostaglandin synthetase inhibitors, indomethacin and flufenamic acid, on these parameters.
Regulation (effect) of prostaglandin synthetase
5) Confidence 0.27 Published 1981 Journal Prostaglandins Med Section Abstract Doc Link 6792643 Disease Relevance 0.15 Pain Relevance 0.12
Differential effect of prostaglandin synthetase inhibitor pretreatment on pentylenetetrazol-induced seizures in rat.
Regulation (effect) of prostaglandin synthetase associated with convulsion
6) Confidence 0.10 Published 1985 Journal Arch Int Pharmacodyn Ther Section Title Doc Link 3927864 Disease Relevance 0.43 Pain Relevance 0.07
Effect of prostaglandin synthetase inhibitors on non-analgesic actions of morphine.
Regulation (Effect) of prostaglandin synthetase associated with analgesic and morphine
7) Confidence 0.03 Published 1983 Journal Eur. J. Pharmacol. Section Title Doc Link 6409656 Disease Relevance 0.72 Pain Relevance 0.93

General Comments

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