INT36100

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Context Info
Confidence 0.49
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.18
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Il2rb (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 10 99.84 Very High Very High Very High
spinal inflammation 9 97.52 Very High Very High Very High
cytokine 14 95.08 Very High Very High Very High
rheumatoid arthritis 4 92.56 High High
Pain score 1 88.24 High High
Inflammatory response 2 87.56 High High
opioid receptor 1 85.36 High High
Inflammation 3 79.24 Quite High
tramadol 2 50.00 Quite Low
Paracetamol 2 42.24 Quite Low
Disease Link Frequency Relevance Heat
Infection 35 99.16 Very High Very High Very High
Cancer 12 98.84 Very High Very High Very High
Disease 31 98.60 Very High Very High Very High
Necrosis 2 98.60 Very High Very High Very High
Low Back Pain 9 97.52 Very High Very High Very High
Apoptosis 5 93.84 High High
Rheumatoid Arthritis 4 92.56 High High
Encephalitis 15 91.28 High High
Death 6 90.00 High High
Pain 3 88.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: In vitro, both cell lines demonstrated a functional type I IGF receptor, as shown by the rapid activation of ribosomal p70 S6 kinase after stimulation with rhIGF-I.
Positive_regulation (activation) of p70
1) Confidence 0.49 Published 2000 Journal Cancer Chemother. Pharmacol. Section Body Doc Link 10647497 Disease Relevance 0 Pain Relevance 0
ELISA data showed that both IL-12 p40 and p70 were increased by morphine.
Positive_regulation (increased) of p70 associated with morphine
2) Confidence 0.33 Published 2000 Journal J. Leukoc. Biol. Section Abstract Doc Link 11073113 Disease Relevance 0.26 Pain Relevance 1.08
Arginine butyrate, a histone deacetylase (HDAC) inhibitor, was shown to increase IL-2R?
Positive_regulation (increase) of IL-2R
3) Confidence 0.16 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727893 Disease Relevance 1.10 Pain Relevance 0
In four patients where serum sIL-2 R levels fell and clinical improvement occurred, subsequent spontaneous increases of serum sIL-2 R level preceded increased clinical disease activity by up to 2 weeks.
Positive_regulation (increases) of sIL-2 R associated with disease
4) Confidence 0.08 Published 1988 Journal J. Autoimmun. Section Abstract Doc Link 3266993 Disease Relevance 0.66 Pain Relevance 0.25
FasL and IL-2R were upregulated in the beginning of infection and deceased further.
Positive_regulation (upregulated) of IL-2R associated with infection
5) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797643 Disease Relevance 0.99 Pain Relevance 0.11
In this study, we demonstrated increased serum levels of soluble interleukin-2 receptor (sIL-2R), Interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in patients with AS compared with healthy subjects.
Positive_regulation (increased) of sIL-2R associated with spinal inflammation, necrosis and cancer
6) Confidence 0.00 Published 2007 Journal Clin. Rheumatol. Section Abstract Doc Link 16583185 Disease Relevance 1.17 Pain Relevance 0.88
There were significant increases in levels of sIL-2R at 4 and 24 hours after operation in group II as compared with baseline levels (P < .05) and at 24 hours after operation in group I (P < .01).
Positive_regulation (increases) of sIL-2R
7) Confidence 0.00 Published 2005 Journal J Clin Anesth Section Body Doc Link 16171665 Disease Relevance 0 Pain Relevance 0

General Comments

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