INT36119

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Context Info
Confidence 0.60
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.79
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CLPP) mitochondrion (CLPP)
Anatomy Link Frequency
brain 1
mononuclear cells 1
CLPP (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 2 99.84 Very High Very High Very High
bradykinin 4 99.80 Very High Very High Very High
Enkephalin 6 99.20 Very High Very High Very High
Morphine 8 98.68 Very High Very High Very High
cocaine 8 97.90 Very High Very High Very High
cerebral cortex 1 94.12 High High
substance P 47 72.60 Quite High
Somatostatin 1 71.48 Quite High
Dynorphin 1 65.80 Quite High
agonist 7 7.60 Low Low
Disease Link Frequency Relevance Heat
Leukemia 4 99.56 Very High Very High Very High
Natriuresis 3 98.08 Very High Very High Very High
Hypotension 2 93.12 High High
INFLAMMATION 9 5.00 Very Low Very Low Very Low
Nicotine Addiction 3 5.00 Very Low Very Low Very Low
Asthma 3 5.00 Very Low Very Low Very Low
Anaplastic Astrocytoma 2 5.00 Very Low Very Low Very Low
Occupational Lung Diseases 2 5.00 Very Low Very Low Very Low
Lung Cancer 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phytohemagglutinin-P, morphine and synthetic enkephalins did not induce the activity of neutral endopeptidase nor the expression of common acute lymphoblastic leukemia antigen.
Gene_expression (expression) of endopeptidase associated with leukemia, enkephalin and morphine
1) Confidence 0.60 Published 1993 Journal Cell Biochem. Funct. Section Abstract Doc Link 8403235 Disease Relevance 0.19 Pain Relevance 0.69
When treated with concanavalin A and cocaine, peripheral blood mononuclear cells showed an enhanced activity (+110 per cent) of the membrane neutral endopeptidase, which was not related to the expression of the common acute lymphoblastic leukemia antigen at the cell surface, although both molecules have the identical amino acid sequence.
Gene_expression (expression) of endopeptidase in mononuclear cells associated with leukemia and cocaine
2) Confidence 0.52 Published 1993 Journal Cell Biochem. Funct. Section Abstract Doc Link 8403235 Disease Relevance 0.18 Pain Relevance 0.67
Purification and characterization of two soluble Cl(-)-activated arginyl aminopeptidases from human brain and their endopeptidase action on neuropeptides.
Gene_expression (action) of endopeptidase in brain associated with neuropeptide
3) Confidence 0.37 Published 1988 Journal J. Neurochem. Section Title Doc Link 3275739 Disease Relevance 0 Pain Relevance 0.36
The high affinity of this endopeptidase for bradykinin (Km = 10 microM) and for atrial natriuretic peptide (Km = 5 microM) suggests that it may play a physiological role in the inactivation of these circulating hypotensive peptide hormones.
Gene_expression (affinity) of endopeptidase associated with natriuresis, hypotension and bradykinin
4) Confidence 0.08 Published 1999 Journal Braz. J. Med. Biol. Res. Section Abstract Doc Link 10347768 Disease Relevance 0.42 Pain Relevance 0.21
Tachykinins, tachykinin receptors and neutral endopeptidase expression
Gene_expression (expression) of endopeptidase
5) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2959027 Disease Relevance 0 Pain Relevance 0

General Comments

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