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Context Info
Confidence 0.59
First Reported 1988
Last Reported 1995
Negated 2
Speculated 1
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.78
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CLPP) mitochondrion (CLPP)
Anatomy Link Frequency
nasal mucosa 1
mononuclear cells 1
CLPP (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 4 100.00 Very High Very High Very High
Morphine 4 100.00 Very High Very High Very High
Calcitonin gene-related peptide 1 98.66 Very High Very High Very High
Enkephalin 4 94.40 High High
Opioid 1 90.56 High High
Dynorphin 1 88.60 High High
Somatostatin 1 83.04 Quite High
substance P 1 81.88 Quite High
bradykinin 1 80.76 Quite High
headache 1 79.84 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 1 87.92 High High
Chronic Sinusitis 2 87.20 High High
Nasal Obstruction 1 82.56 Quite High
Leukemia 2 81.80 Quite High
Lumbar Puncture Related Headaches 1 80.88 Quite High
Epilepsy 1 80.00 Quite High
Headache 1 79.84 Quite High
INFLAMMATION 4 76.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, neutral endopeptidase was not affected by enalapril.
Neg (not) Regulation (affected) of endopeptidase
1) Confidence 0.59 Published 1993 Journal Clin. Sci. Section Abstract Doc Link 8384953 Disease Relevance 0.16 Pain Relevance 0.09
The aminopeptidase activity was stimulated 20-fold by Cl- ions, whereas the endopeptidase activity was unaffected by the latter.
Neg (unaffected) Regulation (unaffected) of endopeptidase
2) Confidence 0.33 Published 1988 Journal J. Neurochem. Section Abstract Doc Link 3275739 Disease Relevance 0 Pain Relevance 0.32
Effect of cocaine and morphine on neutral endopeptidase activity of human peripheral blood mononuclear cells cultured with lectins.
Regulation (Effect) of endopeptidase in mononuclear cells associated with morphine and cocaine
3) Confidence 0.24 Published 1993 Journal Cell Biochem. Funct. Section Title Doc Link 8403235 Disease Relevance 0.15 Pain Relevance 0.68
Human nasal mucosa biopsy samples were studied by biochemical and histological methods to determine whether the concentration of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) as a marker of sensory nerves was dependent on the activity of neutral endopeptidase-like enzyme (NEP-LE).
Spec (whether) Regulation (dependent) of endopeptidase in nasal mucosa associated with calcitonin gene-related peptide
4) Confidence 0.09 Published 1995 Journal Eur Arch Otorhinolaryngol Section Abstract Doc Link 8719587 Disease Relevance 0.47 Pain Relevance 0.29

General Comments

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