INT36132

Context Info Confidence 0.43 First Reported 1981 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 12 Total Number 12 Disease Relevance 15.15 Pain Relevance 1.73

Anatomy Link Frequency vagina 2 genitalium 1 pid (Mus musculus)

Pain Link Frequency Relevance Heat rheumatoid arthritis 1 99.72 Inflammation 31 94.76 Lasting pain 3 94.00 abdominal pain 7 91.76 anesthesia 1 91.28 imagery 1 89.84 pain pelvic 11 86.48 Dismenorea 5 68.44 Pain 5 56.24 Acute pain 1 33.20

Disease Link Frequency Relevance Heat Chlamydia Infection 270 100.00 Rheumatoid Arthritis 1 99.72 Infection 41 99.28 Iron-deficiency Anemia 1 99.28 Reprotox - General 2 27 98.76 Reprotox - General 3 83 98.30 Gonorrhea 8 95.24 Suppuration 1 94.16 Pain 9 94.00 Ovarian Cancer 1 93.76

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In addition, a study from 1996 found evidence that screening for CT had reduced PID in women by as much as 60% [18].

Negative_regulation (reduced) of PID associated with chlamydia infection

1) Confidence 0.43 Published 2006 Journal BMC Womens Health Section Body Doc Link PMC1624808 Disease Relevance 0.30 Pain Relevance 0

Prevention of PID include elimination of risk factors, the careful selection of IUD users, regular checkups, the use of copper (Cu) T device, and strict adherence to professional standards.

Negative_regulation (Prevention) of PID associated with chlamydia infection

2) Confidence 0.37 Published 1986 Journal Orv Hetil Section Abstract Doc Link 3763205 Disease Relevance 1.06 Pain Relevance 0.13

It is often difficult to detect, manage, and prevent PID.

Negative_regulation (prevent) of PID associated with chlamydia infection

3) Confidence 0.37 Published 1993 Journal Afr Health Section Abstract Doc Link 12344839 Disease Relevance 1.21 Pain Relevance 0.20

Screening for and treatment of Chlamydia infection can prevent PID.

Negative_regulation (prevent) of PID associated with chlamydia infection

4) Confidence 0.37 Published 2010 Journal Obstet Gynecol Section Abstract Doc Link 20664404 Disease Relevance 1.55 Pain Relevance 0.18

There is evidence that surgical cleansing of the vagina has no bearing on incidence of post-abortal PID, since the responsible organisms come from the endocervix. 5 controlled clinical trials demonstrated that antibiotic prophylaxis is warranted; that penicillin/ampicillin selectively reduced PID in women with PID history; that imidazoles preferentially reduce PID in the general population without PID history.

Negative_regulation (reduced) of PID in vagina associated with chlamydia infection

5) Confidence 0.37 Published 1988 Journal Dan Med Bull Section Abstract Doc Link 3277798 Disease Relevance 1.67 Pain Relevance 0.27

There is evidence that surgical cleansing of the vagina has no bearing on incidence of post-abortal PID, since the responsible organisms come from the endocervix. 5 controlled clinical trials demonstrated that antibiotic prophylaxis is warranted; that penicillin/ampicillin selectively reduced PID in women with PID history; that imidazoles preferentially reduce PID in the general population without PID history.

Negative_regulation (reduce) of PID in vagina associated with chlamydia infection

6) Confidence 0.37 Published 1988 Journal Dan Med Bull Section Abstract Doc Link 3277798 Disease Relevance 1.53 Pain Relevance 0.25

Screening for asymptomatic chlamydial infection is the mainstay of prevention of PID.

Negative_regulation (prevention) of PID associated with chlamydia infection

7) Confidence 0.36 Published 1998 Journal Dermatol Clin Section Abstract Doc Link 9891675 Disease Relevance 1.42 Pain Relevance 0.16

There has been only one major trial in non-pregnant women of chlamydia screening to prevent PID[2].

Negative_regulation (prevent) of PID associated with chlamydia infection

8) Confidence 0.36 Published 2008 Journal Trials Section Body Doc Link PMC2614935 Disease Relevance 1.24 Pain Relevance 0.12

Prevention of recurrent PID and better understanding of the pathophysiology of postinfection tubal damage (which may differ between chlamydia and gonorrhea) is needed to develop more effective strategies to reduce permanent tubal damage.

Negative_regulation (Prevention) of PID associated with gonorrhea and chlamydia infection

9) Confidence 0.35 Published 1999 Journal Infect Dis Obstet Gynecol Section Abstract Doc Link PMC1784727 Disease Relevance 1.76 Pain Relevance 0.09

The goal is to prevent PID by identifying cervicitis and endometritis before salpingitis develops and by advocating contraceptive methods that will reduce attack rates.

Negative_regulation (prevent) of PID associated with reprotox - general 2 and chlamydia infection

10) Confidence 0.26 Published 1985 Journal IPPF Med Bull Section Abstract Doc Link 12280152 Disease Relevance 1.45 Pain Relevance 0.17

Iron deficiency anemia, rheumatoid arthritis, and initial PID were also prevented.

Negative_regulation (prevented) of PID associated with iron-deficiency anemia, rheumatoid arthritis and chlamydia infection

11) Confidence 0.06 Published 1981 Journal Contracept Technol Update Section Abstract Doc Link 12338027 Disease Relevance 1.21 Pain Relevance 0.16

It may be that M. genitalium was not associated with SAB in our study population of pregnant women because women with M. genitalium go on to develop PID and subfertility and would therefore not be enrolled in our study.

Negative_regulation (develop) of PID in genitalium associated with reprotox - general 3 and chlamydia infection

12) Confidence 0.03 Published 2010 Journal Infectious Diseases in Obstetrics and Gynecology Section Body Doc Link PMC2850137 Disease Relevance 0.77 Pain Relevance 0

General Comments

This test has worked.