INT36135

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Context Info
Confidence 0.50
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 19
Total Number 19
Disease Relevance 1.77
Pain Relevance 7.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal 5
skin 1
CSE (Homo sapiens)
Pain Link Frequency Relevance Heat
epidural 118 100.00 Very High Very High Very High
headache 5 99.52 Very High Very High Very High
analgesia 21 99.08 Very High Very High Very High
local anesthetic 7 98.72 Very High Very High Very High
anesthesia 31 97.92 Very High Very High Very High
Analgesic 5 96.76 Very High Very High Very High
Morphine 4 96.48 Very High Very High Very High
Pain 8 96.20 Very High Very High Very High
ischemia 21 94.80 High High
lidocaine 4 89.36 High High
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 4 99.92 Very High Very High Very High
Headache 3 99.52 Very High Very High Very High
Meningitis 2 99.06 Very High Very High Very High
Middle Cerebral Artery Infarction 19 97.88 Very High Very High Very High
Pain 9 96.20 Very High Very High Very High
Cv General 4 Under Development 14 94.80 High High
Infection 4 92.92 High High
Stress 4 66.16 Quite High
INFLAMMATION 3 61.52 Quite High
Post Operative Pain 1 60.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Operative delivery rates might be reduced with CSE, by avoiding or delaying administration of local anesthetics.
Negative_regulation (reduced) of CSE associated with epidural and local anesthetic
1) Confidence 0.50 Published 1998 Journal Anesthesiology Section Abstract Doc Link 9856707 Disease Relevance 0.09 Pain Relevance 0.80
CSE block combines the rapidity, density and reliability of spinal block with the flexibility of continuous epidural to extend the duration of analgesia.
Negative_regulation (block) of CSE in spinal associated with epidural and analgesia
2) Confidence 0.37 Published 1994 Journal Ann. Acad. Med. Singap. Section Abstract Doc Link 7710218 Disease Relevance 0.10 Pain Relevance 0.51
Despite a recent flurry of reports of meningitis with CSE procedures, there is no evidence the CSE block is more hazardous than epidural or subarachnoid block alone.
Negative_regulation (block) of CSE associated with meningitis and epidural
3) Confidence 0.37 Published 2000 Journal Anesthesiol Clin North America Section Abstract Doc Link 10935011 Disease Relevance 0.27 Pain Relevance 0.77
CSE block combines the rapidity, density, and reliability of the subarachnoid block with the flexibility of continuous epidural block to extend duration of analgesia.
Negative_regulation (block) of CSE associated with epidural and analgesia
4) Confidence 0.37 Published 2000 Journal Anesthesiol Clin North America Section Abstract Doc Link 10935011 Disease Relevance 0 Pain Relevance 0.32
CSE block appears to combine the reliability of spinal block and the flexibility of epidural block while minimizing their drawbacks.
Negative_regulation (block) of CSE in spinal associated with epidural
5) Confidence 0.37 Published 1988 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 3278500 Disease Relevance 0.27 Pain Relevance 0.98
Indications, advantages, disadvantages, and the various methods for performing CSE procedures, including sequential CSE block, are described and reviewed, along with the equipment currently available for their administration.
Negative_regulation (block) of CSE
6) Confidence 0.37 Published 1997 Journal Reg Anesth Section Body Doc Link 9338901 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Subarachnoid block was preferred for shorter surgical procedures (< 60 min), whereas epidural and CSE blocks were chosen when severe postoperative pain could be anticipated, as continuous epidural analgesia was well established for postoperative pain management.
Negative_regulation (blocks) of CSE
7) Confidence 0.37 Published 1997 Journal Acta Anaesthesiol Scand Section Body Doc Link 9181156 Disease Relevance 0 Pain Relevance 0
CSE block was used by 42 departments and CSA by 21 departments.
Negative_regulation (block) of CSE
8) Confidence 0.37 Published 1997 Journal Acta Anaesthesiol Scand Section Body Doc Link 9181156 Disease Relevance 0 Pain Relevance 0
It is concluded that the analgesia and surgical conditions provided by the spinal and CSE blocks were similar and were superior to those provided by an epidural block.
Negative_regulation (blocks) of CSE in spinal associated with epidural and analgesia
9) Confidence 0.37 Published 1993 Journal Can J Anaesth Section Abstract Doc Link 8104724 Disease Relevance 0.06 Pain Relevance 1.33
The muscular relaxation was also better following CSE block.
Negative_regulation (block) of CSE associated with epidural
10) Confidence 0.37 Published 1988 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 3278500 Disease Relevance 0.23 Pain Relevance 1.05
All patients receiving CSE block had good to excellent analgesia, while 11 patients (74%) receiving epidural block had similar pain relief.
Negative_regulation (block) of CSE associated with pain, epidural and analgesia
11) Confidence 0.37 Published 1988 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 3278500 Disease Relevance 0.15 Pain Relevance 0.91
Technical problems, unsuccessful CSE block, and damaged spinal needle tip were noted relatively often with the interlocking CSE set.
Negative_regulation (block) of CSE in spinal
12) Confidence 0.37 Published 2001 Journal Reg Anesth Pain Med Section Body Doc Link 11172506 Disease Relevance 0 Pain Relevance 0
RESULTS: The frequency of the successful CSE block was higher in groups 3 (100%) and 2 (90%) than in group 1 (63%) (P <.05).
Negative_regulation (block) of CSE
13) Confidence 0.37 Published 2001 Journal Reg Anesth Pain Med Section Body Doc Link 11172506 Disease Relevance 0 Pain Relevance 0
Glibenclamide, a K(ATP) channel inhibitor, and DL-propargylglycine, a CSE inhibitor, exacerbated, whereas pinacidil, a K(ATP) opener, attenuated gastric injury caused by ASA.
Negative_regulation (inhibitor) of CSE
14) Confidence 0.18 Published 2005 Journal Gastroenterology Section Body Doc Link 16230075 Disease Relevance 0.06 Pain Relevance 0
CSE block was performed at L3-L4 (26G pensil-point spinal needle and 18G catheter).
Negative_regulation (block) of CSE in spinal
15) Confidence 0.10 Published 1997 Journal Anesteziol Reanimatol Section Abstract Doc Link 9432896 Disease Relevance 0 Pain Relevance 0.68
Pretreatment with an inhibitor of CSE prevented the allodynia/hyperalgesia, but not the pancreatitis.
Negative_regulation (inhibitor) of CSE
16) Confidence 0.10 Published 2009 Journal Gut Section Body Doc Link 19201768 Disease Relevance 0.06 Pain Relevance 0
CSE prevented the increase in plasma glucose concentration during and immediately after the operation (60 min after skin incision: CSE 4.9 +/- 0.7 versus control 6.2 +/- 0.7 mmol/L; P < 0.05; postanesthesia care unit: CSE 5.0 +/- 0.9 versus control 7.3 +/- 1.1 mmol/L; P < 0.05).
Negative_regulation (prevented) of CSE in skin
17) Confidence 0.06 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 16192545 Disease Relevance 0 Pain Relevance 0.41
In the CSE-8 and CSE-10 group, a significant decrease was seen in the level of LPO when compared with the MCAO group (Table 5).
Negative_regulation (decrease) of CSE associated with middle cerebral artery infarction
18) Confidence 0.04 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2984477 Disease Relevance 0.47 Pain Relevance 0.05
Additional therapy with CSE inhibitors in two of the three patients led to the wrong conclusion as drug-specific side effect.
Negative_regulation (inhibitors) of CSE
19) Confidence 0.03 Published 2002 Journal Med. Klin. (Munich) Section Body Doc Link 11957791 Disease Relevance 0 Pain Relevance 0

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