INT3614

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Context Info
Confidence 0.42
First Reported 1976
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 16
Total Number 22
Disease Relevance 6.80
Pain Relevance 5.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gh1) signal transduction (Gh1) mitochondrion (Gh1)
extracellular space (Gh1) extracellular region (Gh1) plasma membrane (Gh1)
Anatomy Link Frequency
plasma 4
pituitary 4
blood 2
thyroid 2
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 72 100.00 Very High Very High Very High
Inflammation 209 99.52 Very High Very High Very High
Somatostatin 41 98.90 Very High Very High Very High
Morphine 18 96.80 Very High Very High Very High
antagonist 14 96.68 Very High Very High Very High
opiate 5 96.20 Very High Very High Very High
withdrawal 2 96.12 Very High Very High Very High
Glutamate 8 96.04 Very High Very High Very High
Opioid 14 95.76 Very High Very High Very High
substance P 16 94.72 High High
Disease Link Frequency Relevance Heat
Arthritis 74 100.00 Very High Very High Very High
INFLAMMATION 219 99.52 Very High Very High Very High
Stress 68 98.80 Very High Very High Very High
Diabetes Mellitus 22 97.64 Very High Very High Very High
Hyperglycemia 7 96.56 Very High Very High Very High
Rheumatoid Arthritis 243 94.64 High High
Disease 96 93.52 High High
Acromegaly 182 93.00 High High
Body Weight 8 90.84 High High
Aids-related Complex 2 88.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In eight-day-old pups, yohimbine prevented the nursing-induced increase in serum GH and decreased GH levels below the saline-injected, separated control.
Negative_regulation (decreased) of Gene_expression (levels) of GH
1) Confidence 0.42 Published 1993 Journal Acta Endocrinol. Section Abstract Doc Link 8383905 Disease Relevance 0 Pain Relevance 0.45
Mean 5-h plasma GH levels were reduced, whereas PRL levels were not affected.
Negative_regulation (reduced) of Gene_expression (levels) of GH in plasma
2) Confidence 0.42 Published 1982 Journal Endocrinology Section Abstract Doc Link 6120072 Disease Relevance 0.25 Pain Relevance 0.18
In addition they suggest that impairment of GH secretion in thyroidectomized rats does not depend upon changes in the hypothalamic SRIF regulation of the hormone but could be dependent on a defect in GRF release and/or, most probably, GH synthesis directly at the pituitary level.
Negative_regulation (defect) of Gene_expression (synthesis) of GH in pituitary associated with somatostatin
3) Confidence 0.42 Published 1985 Journal Neuroendocrinology Section Abstract Doc Link 2867482 Disease Relevance 0 Pain Relevance 0.28
Circulating GH levels were significantly decreased following a brief (2 min) exposure to either, during repetitive etherization coupled with blood withdrawal, and during continuous immobilization.
Negative_regulation (decreased) of Gene_expression (levels) of GH in blood associated with withdrawal
4) Confidence 0.38 Published 1984 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 6473349 Disease Relevance 0.39 Pain Relevance 0.53
Pulsatile administration of GH (40 micrograms/day/rat, with successive periods of 2 h of GH and 4 h of mineral oil) restoring the endogenous GH-secretory pattern throughout the 15-day period of arthritis development prevents hindpaw diameter increase.
Negative_regulation (prevents) of Gene_expression (administration) of GH associated with arthritis
5) Confidence 0.38 Published 1996 Journal Neuroendocrinology Section Abstract Doc Link 8839359 Disease Relevance 0.91 Pain Relevance 0.75
Pulsatile administration of GH (40 micrograms/day/rat, with successive periods of 2 h of GH and 4 h of mineral oil) restoring the endogenous GH-secretory pattern throughout the 15-day period of arthritis development prevents hindpaw diameter increase.
Negative_regulation (prevents) of Gene_expression (administration) of GH associated with arthritis
6) Confidence 0.38 Published 1996 Journal Neuroendocrinology Section Abstract Doc Link 8839359 Disease Relevance 0.91 Pain Relevance 0.75
Absence of GH pulsatility during food-deprivation, coupled with no decrease in GH levels in food-deprived rats treated with GHRHab suggest that diminished GHRH pulsatility is likely during food-deprivation.
Neg (no) Negative_regulation (decrease) of Gene_expression (levels) of GH
7) Confidence 0.36 Published 1992 Journal Life Sci. Section Abstract Doc Link 1347904 Disease Relevance 0.14 Pain Relevance 0.37
In intact controls, baseline GH levels were in the range 40.0 to 80.0 ng/ml and were drastically reduced by urethane.
Negative_regulation (reduced) of Gene_expression (levels) of GH
8) Confidence 0.35 Published 1976 Journal Endocrinology Section Abstract Doc Link 816640 Disease Relevance 0 Pain Relevance 0.05
Six switch patients (23.1%) had discordant IGF-1 and glucose-suppressed GH levels <1 ?
Negative_regulation (suppressed) of Gene_expression (levels) of GH
9) Confidence 0.31 Published 2009 Journal Pituitary Section Body Doc Link PMC2855862 Disease Relevance 0.15 Pain Relevance 0
Glucose-suppressed GH levels were <1 ?
Negative_regulation (suppressed) of Gene_expression (levels) of GH
10) Confidence 0.31 Published 2009 Journal Pituitary Section Body Doc Link PMC2855862 Disease Relevance 0.16 Pain Relevance 0
Glucose-suppressed GH levels were obtained in most patients; they were not obtained in diabetic patients or all of the early termination patients.
Negative_regulation (suppressed) of Gene_expression (levels) of GH associated with diabetes mellitus
11) Confidence 0.31 Published 2009 Journal Pituitary Section Body Doc Link PMC2855862 Disease Relevance 0.10 Pain Relevance 0.15
Discordant IGF-1 and glucose-suppressed GH levels <1 ?
Negative_regulation (suppressed) of Gene_expression (levels) of GH
12) Confidence 0.31 Published 2009 Journal Pituitary Section Body Doc Link PMC2855862 Disease Relevance 0.16 Pain Relevance 0
A recent study by Carmichael et al. [12] found that glucose-suppressed GH levels (<2 ?
Negative_regulation (suppressed) of Gene_expression (levels) of GH
13) Confidence 0.31 Published 2009 Journal Pituitary Section Body Doc Link PMC2855862 Disease Relevance 0.39 Pain Relevance 0
Glucose-suppressed GH levels were <1 ?
Negative_regulation (suppressed) of Gene_expression (levels) of GH
14) Confidence 0.31 Published 2009 Journal Pituitary Section Body Doc Link PMC2855862 Disease Relevance 0.16 Pain Relevance 0
Five “other” patients (21.7%) had discordant IGF-1 and glucose-suppressed GH levels <1 ?
Negative_regulation (suppressed) of Gene_expression (levels) of GH
15) Confidence 0.31 Published 2009 Journal Pituitary Section Body Doc Link PMC2855862 Disease Relevance 0.13 Pain Relevance 0
The mechanisms involved in such effects were evaluated by measuring pituitary GH mRNA levels and hypothalamic levels of GH-releasing hormone (GHRH) and somatostatin (SRIF) mRNAs.
Negative_regulation (measuring) of Gene_expression (levels) of GH in pituitary associated with somatostatin
16) Confidence 0.30 Published 1996 Journal J. Endocrinol. Section Abstract Doc Link 8958779 Disease Relevance 0 Pain Relevance 0.30
The acute hyperglycemic effect of KX in fed rats was associated with decreased plasma levels of insulin, adrenocorticotropic hormone (ACTH), and corticosterone and increased levels of glucagon and growth hormone (GH).
Negative_regulation (decreased) of Gene_expression (levels) of GH in plasma
17) Confidence 0.23 Published 2005 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 16246906 Disease Relevance 0.55 Pain Relevance 0.32
In contrast, elevated levels of GH in ambulatory animals inhibit the positive affect of IGF-I, indicating that in fact elevated GH in ambulatory animals may not be permissive to elevated IGF-I function, but that improved healing from IGF-I addition is not dependent on exogenously elevated GH levels.
Negative_regulation (inhibit) of Gene_expression (levels) of GH
18) Confidence 0.20 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1851714 Disease Relevance 0.07 Pain Relevance 0
L-692,400, which is structurally related to L-692,429 but biologically inactive, inhibited GH response not only to L-692,429 but also GHRP-6.
Negative_regulation (inhibited) of Gene_expression (response) of GH
19) Confidence 0.16 Published 1993 Journal Horm. Res. Section Abstract Doc Link 7905455 Disease Relevance 0 Pain Relevance 0.29
In spite of an initial rise in GH secretion, GH action is reduced because of GH and IGF-1 resistance induced by inflammation.
Negative_regulation (reduced) of Gene_expression (action) of GH associated with inflammation
20) Confidence 0.05 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC333413 Disease Relevance 0.60 Pain Relevance 0.14

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