INT36148

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Context Info
Confidence 0.41
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 7.91
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (GAD1) plasma membrane (GAD1) intracellular (GAD1)
Anatomy Link Frequency
cerebrospinal fluid 1
GAD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 85 96.80 Very High Very High Very High
antidepressant 15 96.56 Very High Very High Very High
GABAergic 120 93.72 High High
Cannabinoid receptor 14 91.60 High High
pregabalin 68 86.32 High High
depression 42 85.40 High High
Central nervous system 4 72.52 Quite High
Neurotransmitter 11 71.32 Quite High
Pain 8 68.84 Quite High
sSRI 39 66.48 Quite High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 226 100.00 Very High Very High Very High
Depression 58 99.40 Very High Very High Very High
Anxiety Disorder 128 98.32 Very High Very High Very High
Epilepsy 5 98.16 Very High Very High Very High
Diabetes Mellitus-type I 3 97.60 Very High Very High Very High
Diabetes Mellitus 6 97.36 Very High Very High Very High
Disease 31 93.56 High High
Stiff-person Syndrome 34 92.80 High High
Cancer 22 92.64 High High
Lifespan 31 91.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consequently, the community cost associated with GAD is high [6].
GAD Binding (associated) of associated with generalized anxiety disorder
1) Confidence 0.41 Published 2010 Journal Trials Section Body Doc Link PMC2878300 Disease Relevance 0.98 Pain Relevance 0.06
Much understanding has come from a positive association with GAD antibodies.
GAD Binding (association) of associated with generalized anxiety disorder
2) Confidence 0.36 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2868875 Disease Relevance 1.58 Pain Relevance 0.22
A band comigrating with glutamic acid decarboxylase in sodium dodecyl sulfate-polyacrylamide gels appeared to be the only nervous-tissue antigen recognized by cerebrospinal fluid antibodies, and the predominant antigen recognized by serum antibodies.
glutamic acid decarboxylase Binding (comigrating) of in cerebrospinal fluid
3) Confidence 0.35 Published 1988 Journal N. Engl. J. Med. Section Abstract Doc Link 3281011 Disease Relevance 0.89 Pain Relevance 0.10
Reduction in worry will be measured by the Penn State Worry Questionnaire (PSWQ) [46] and the Anxious Thoughts Inventory (AnTI) [47]; reduced impact of worry and anxiety on participants' lives by the Life Interference Scale (LIS); reduction of somatic symptoms associated with GAD by the somatic subscale of the Worry and Anxiety Questionnaire (WAQ-Som) [48] and reduction in anxiety sensitivity assessed by the Anxiety Sensitivity Index (ASI) [49].
GAD Binding (associated) of associated with generalized anxiety disorder and anxiety disorder
4) Confidence 0.31 Published 2010 Journal Trials Section Body Doc Link PMC2878300 Disease Relevance 1.17 Pain Relevance 0.21
The alternate ICD-10 classification also recognises GAD as a separate disorder of chronic duration (6 months) but differs from DSM-IV with respect to the pervasiveness of the symptomatology.
GAD Binding (recognises) of associated with generalized anxiety disorder
5) Confidence 0.28 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2646646 Disease Relevance 1.34 Pain Relevance 0
GAD is common in community and primary care settings, tends to run a chronic course, and is associated with significant occupational impairment.
GAD Binding (associated) of associated with generalized anxiety disorder
6) Confidence 0.28 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654626 Disease Relevance 1.33 Pain Relevance 0.49
Louis, MO) and, in some cases (GAD 65&67; CB D-28K and TH) the reaction was intensified with Nickel Sulfate Hexahydrate (Sigma, St.
GAD Binding (intensified) of associated with generalized anxiety disorder
7) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2566591 Disease Relevance 0.10 Pain Relevance 0
0.26; GAD67, R =?
GAD67 Binding (0.26) of
8) Confidence 0.23 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.13 Pain Relevance 0.31
Gad wrote in Animal Models in Toxicology 2007:
Gad Binding (wrote) of associated with generalized anxiety disorder
9) Confidence 0.09 Published 2009 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2642860 Disease Relevance 0.25 Pain Relevance 0
Both GAD or VGAT and NeuN labeling were extensive and intensive, which demonstrated that the right method and skill were employed.
GAD Binding (intensive) of associated with generalized anxiety disorder
10) Confidence 0.04 Published 2010 Journal Cardiovascular Psychiatry and Neurology Section Body Doc Link PMC2957857 Disease Relevance 0.16 Pain Relevance 0.08

General Comments

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