INT3616

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Context Info
Confidence 0.73
First Reported 1976
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.49
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh, Gh1) nucleus (Trh, Gh1) plasma membrane (Trh, Gh1)
mitochondrion (Gh1) cytoplasm (Trh) cytosol (Gh1)
Anatomy Link Frequency
pituitary 4
thyroid 2
Trh (Rattus norvegicus)
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 4 94.68 High High
Dopamine 26 81.20 Quite High
Somatostatin 12 80.16 Quite High
cytokine 44 62.24 Quite High
depression 4 48.60 Quite Low
antagonist 78 5.00 Very Low Very Low Very Low
Nerve growth factor 56 5.00 Very Low Very Low Very Low
Inflammation 54 5.00 Very Low Very Low Very Low
agonist 44 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 34 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroid Disease 10 75.00 Quite High
Adenoma 10 61.28 Quite High
Cancer 44 61.20 Quite High
Infection 2 60.60 Quite High
Stress 96 55.12 Quite High
Eating Disorder 8 52.04 Quite High
Depression 4 48.60 Quite Low
Critical Illness 2 26.12 Quite Low
INFLAMMATION 56 5.00 Very Low Very Low Very Low
Targeted Disruption 44 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicate that TRH in the hypophysectomized-transplanted rat acts directly on the AP tissue to increase GH release and that the ectopic pituitary is more susceptible than the in situ pituitary to some GH-releasing stimuli.
TRH Positive_regulation (increase) of Localization (release) of GH in pituitary
1) Confidence 0.73 Published 1976 Journal Endocrinology Section Abstract Doc Link 816640 Disease Relevance 0 Pain Relevance 0
In vitro TRH increased GH release from incubated or perifused pituitaries sampled from both intact and lesioned rats in a transient and concentration-dependent manner.
TRH Positive_regulation (increased) of Localization (release) of GH
2) Confidence 0.30 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3097564 Disease Relevance 0 Pain Relevance 0.17
These results suggest that altered thyroid status influences GH release as well as TSH secretion induced by TRH in rats.
TRH Positive_regulation (induced) of Localization (secretion) of GH in thyroid
3) Confidence 0.29 Published 1976 Journal Endocrinology Section Abstract Doc Link 819251 Disease Relevance 0.15 Pain Relevance 0.08
TRH stimulates GH release in neonatal rat pituitary in vivo (431) and in cell culture (232, 417) whereas, in adults, it inhibits GH release stimulated by VIP in vitro (233).
TRH Positive_regulation (stimulates) of Localization (release) of GH in pituitary
4) Confidence 0.02 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.11 Pain Relevance 0
When a dispersed cell preparation consisting of approximately 65% FS cells was coaggregated with a highly enriched populations of hormone-secreting cells and the coaggregates, after 5 days in culture, were perifused with various secretagogues, the stimulation of PRL release by TRH or angiotensin II, of GH release by GHRH and adrenaline, and of LH release by GnRH, was blunted, compared to aggregates consisting of the hormonal cells only (94).
TRH Positive_regulation (stimulation) of Localization (release) of GH
5) Confidence 0.02 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.23 Pain Relevance 0.11

General Comments

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