INT36162

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Context Info
Confidence 0.70
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.87
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
4T1 1
ras (Mus musculus)
Pain Link Frequency Relevance Heat
corticosteroid 2 94.96 High High
topical agent 1 91.48 High High
Inflammatory response 1 86.48 High High
Pain 6 85.28 High High
palliative 1 83.76 Quite High
Kinase C 1 75.00 Quite High
Lasting pain 1 68.76 Quite High
Inflammation 30 58.48 Quite High
cytokine 9 57.44 Quite High
spinal inflammation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Canker Sores 11 100.00 Very High Very High Very High
Disease 29 97.52 Very High Very High Very High
Apoptosis 1 95.88 Very High Very High Very High
Metastasis 3 92.72 High High
Breast Cancer 3 89.52 High High
INFLAMMATION 32 86.48 High High
Diarrhoea 1 85.44 High High
Pain 5 85.28 High High
Cancer 20 84.76 Quite High
Vascular Tissue Neoplasms 1 84.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Enzastaurin treatment of 4T1 cells blocked the phosphorylation of PKCbeta, as well as Ras and two of its downstream effectors ERK1/2 and RAL-GTP.
Phosphorylation (phosphorylation) of Ras in 4T1
1) Confidence 0.70 Published 2008 Journal Invest New Drugs Section Abstract Doc Link 17805485 Disease Relevance 1.14 Pain Relevance 0.27
Patients with frequent exacerbations or those with a severe form of RAS that is unresponsive to topical treatments often require systemic agents to control their disease.
Phosphorylation (form) of RAS associated with disease and canker sores
2) Confidence 0.62 Published 2001 Journal Cutis Section Abstract Doc Link 11579786 Disease Relevance 0.79 Pain Relevance 0.22
We conclude that colchicine therapy should be considered as an alternative in the treatment of the major or persistent form of RAS.
Phosphorylation (form) of RAS associated with canker sores
3) Confidence 0.54 Published 1988 Journal Arch. Otolaryngol. Head Neck Surg. Section Abstract Doc Link 3284550 Disease Relevance 0.91 Pain Relevance 0.07
Several components of the MAPK cascade were also important including Ras binding to GAP and Raf, and the dephosphorylation of ERK.
Phosphorylation (dephosphorylation) of Ras
4) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.08 Pain Relevance 0
On the other hand, the MAP kinase pathway begins with phosphorylation of Shc, Grb2/Sos and ras and results in the activation of extracellular signal-regulated kinase (ERK)-1 and ERK-2.
Phosphorylation (phosphorylation) of ras
5) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483433 Disease Relevance 0.95 Pain Relevance 0.16

General Comments

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