INT3617

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Context Info
Confidence 0.65
First Reported 1976
Last Reported 2008
Negated 1
Speculated 4
Reported most in Abstract
Documents 3
Total Number 8
Disease Relevance 0.55
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh, Gh1) nucleus (Trh, Gh1) plasma membrane (Trh, Gh1)
mitochondrion (Gh1) cytoplasm (Trh) cytosol (Gh1)
Anatomy Link Frequency
Plasma 4
thyroid 4
blood 2
pituitary 2
Trh (Rattus norvegicus)
Gh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 6 95.40 Very High Very High Very High
antagonist 78 89.12 High High
Calcitonin gene-related peptide 34 84.08 Quite High
agonist 45 25.00 Low Low
Clonidine 2 25.00 Low Low
Nerve growth factor 56 5.00 Very Low Very Low Very Low
Inflammation 54 5.00 Very Low Very Low Very Low
cytokine 44 5.00 Very Low Very Low Very Low
substance P 32 5.00 Very Low Very Low Very Low
gABA 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroid Disease 14 100.00 Very High Very High Very High
Obesity 8 81.04 Quite High
Adenoma 10 66.88 Quite High
Immunization 3 25.00 Low Low
Stress 96 5.00 Very Low Very Low Very Low
INFLAMMATION 56 5.00 Very Low Very Low Very Low
Cancer 44 5.00 Very Low Very Low Very Low
Targeted Disruption 44 5.00 Very Low Very Low Very Low
Pituitary Cancer 22 5.00 Very Low Very Low Very Low
Starvation 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma growth hormone (GH) in sequential samples from each rat was measured by radioimmunoassay to determine the effect of exogenous thyrotropin-releasing hormone (TRH) on GH release from ectopic or intact AP.
TRH Spec (determine) Regulation (effect) of Localization (release) of GH in Plasma
1) Confidence 0.65 Published 1976 Journal Endocrinology Section Abstract Doc Link 816640 Disease Relevance 0 Pain Relevance 0.10
Plasma growth hormone (GH) in sequential samples from each rat was measured by radioimmunoassay to determine the effect of exogenous thyrotropin-releasing hormone (TRH) on GH release from ectopic or intact AP.
exogenous thyrotropin-releasing hormone Spec (determine) Regulation (effect) of Localization (release) of GH in Plasma
2) Confidence 0.56 Published 1976 Journal Endocrinology Section Abstract Doc Link 816640 Disease Relevance 0 Pain Relevance 0.10
These findings indicate that TRH can affect GH secretion at the pituitary level under specific experimental conditions and support the hypothesis that either peripheral hormones or other, still unidentified hypothalamic neurohormones may modulate this effect.
TRH Regulation (affect) of Localization (secretion) of GH in pituitary
3) Confidence 0.46 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3097564 Disease Relevance 0 Pain Relevance 0.15
The effect of synthetic thyrotropin-releasing hormone (TRH) on the release of growth hormone (GH) and thyroid-stimulating hormone (TSH) was investigated in euthyroid, hypothyroid, and hyperthyroid rats under urethane anesthesia.
TRH Spec (investigated) Regulation (effect) of Localization (release) of GH in thyroid associated with anesthesia
4) Confidence 0.39 Published 1976 Journal Endocrinology Section Abstract Doc Link 819251 Disease Relevance 0.15 Pain Relevance 0.10
The effect of synthetic thyrotropin-releasing hormone (TRH) on the release of growth hormone (GH) and thyroid-stimulating hormone (TSH) was investigated in euthyroid, hypothyroid, and hyperthyroid rats under urethane anesthesia.
synthetic thyrotropin-releasing hormone Spec (investigated) Regulation (effect) of Localization (release) of GH in thyroid associated with anesthesia
5) Confidence 0.34 Published 1976 Journal Endocrinology Section Abstract Doc Link 819251 Disease Relevance 0.15 Pain Relevance 0.10
To characterize the role of TRH in the generation of TSH pulsatility as well as the effect of hypothyroidism on episodic GH secretion, blood was constantly withdrawn (30-60 microliters/min) from rats treated with 0.02% methimazole in the drinking water for 8-10 days.
TRH Regulation (role) of Localization (secretion) of GH in blood associated with thyroid disease
6) Confidence 0.11 Published 1992 Journal Endocrinology Section Abstract Doc Link 1446603 Disease Relevance 0.10 Pain Relevance 0
Also, TRH has dual effects on GH secretion, with a stimulatory component more pronounced in neonatal rats (232) and an inhibitory component prevailing at later age (233).
TRH Regulation (effects) of Localization (secretion) of GH
7) Confidence 0.02 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.09
However, release of GH was not affected, suggesting that no autocrine loop of TRH on GH secretion is operative under conditions where it was acting in a paracrine manner.
TRH Neg (no) Regulation (loop) of Localization (secretion) of GH
8) Confidence 0.01 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.15 Pain Relevance 0

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