INT36177

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Context Info
Confidence 0.31
First Reported 1981
Last Reported 2010
Negated 4
Speculated 3
Reported most in Body
Documents 70
Total Number 75
Disease Relevance 35.47
Pain Relevance 13.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Alms1) cilium (Alms1) molecular_function (Alms1)
lipid metabolic process (Alms1) cytoplasm (Alms1)
Anatomy Link Frequency
brain 12
endothelial cell 4
CNS 3
leukocyte 3
plasma 2
Alms1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 1327 100.00 Very High Very High Very High
Glutamate 18 99.30 Very High Very High Very High
cytokine 310 99.28 Very High Very High Very High
Neuropeptide 71 99.06 Very High Very High Very High
Neuritis 108 98.90 Very High Very High Very High
ischemia 203 98.64 Very High Very High Very High
imagery 237 98.08 Very High Very High Very High
Multiple sclerosis 413 97.36 Very High Very High Very High
positron emission tomography 43 96.60 Very High Very High Very High
Bile 2 96.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Autoimmune Disease 121 99.90 Very High Very High Very High
Apoptosis 81 99.76 Very High Very High Very High
Hypothermia 165 99.72 Very High Very High Very High
Brain Tumor 100 99.66 Very High Very High Very High
Alzheimer's Dementia 181 99.54 Very High Very High Very High
Anaerobic Bacterial Infections 38 99.52 Very High Very High Very High
Pressure And Volume Under Development 51 99.42 Very High Very High Very High
Cognitive Disorder 61 99.36 Very High Very High Very High
Rodent Diseases 1 99.36 Very High Very High Very High
Stroke 334 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Novel technologies, capable of enhancing BBB permeation, are also discussed relative to improving CNS therapies for these disease states.
BBB Binding (permeation) of in CNS associated with central nervous system and disease
1) Confidence 0.31 Published 2008 Journal Drug Dev Ind Pharm Section Abstract Doc Link 18720140 Disease Relevance 0.97 Pain Relevance 0.32
Ideally, a nanodelivery-drug complex would be administered systemically (for example, intravenously) but would find the CNS while producing minimal systemic effects, be able to cross the BBB and correctly target cells in the CNS, and then carry out its primary active function, such as releasing a drug.
BBB Binding (cross) of in CNS associated with central nervous system
2) Confidence 0.28 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604882 Disease Relevance 0.09 Pain Relevance 0.18
By taking advantage of the ability of these solid lipid nanoparticles to cross the BBB, nanoparticles complexed with iron oxides may provide new ways to image the CNS using MRI.
BBB Binding (cross) of associated with central nervous system and imagery
3) Confidence 0.28 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604882 Disease Relevance 0.26 Pain Relevance 0.21
The main difficulty with antibodies is that they cross the BBB poorly.
BBB Binding (cross) of
4) Confidence 0.23 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604887 Disease Relevance 0.90 Pain Relevance 0.07
Most CNS therapeutics are small, lipid soluble molecules that are likely to rely upon transmembrane diffusion to cross the BBB.
BBB Spec (likely) Binding (cross) of associated with central nervous system
5) Confidence 0.23 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604887 Disease Relevance 0.17 Pain Relevance 0.52
It may be a form of these vesicular mechanisms that the larger universal carriers are co-opting, just as some viruses exploit aspects of transport processes to cross the BBB.
BBB Binding (cross) of
6) Confidence 0.23 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604887 Disease Relevance 0 Pain Relevance 0.17
Thus, they are ideal for crossing the BBB by way of the extracellular pathways.
BBB Binding (crossing) of
7) Confidence 0.23 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604887 Disease Relevance 0.78 Pain Relevance 0.13
Many of these cross the BBB by way of saturable transport systems to exert their effects on the CNS.
BBB Binding (cross) of associated with central nervous system
8) Confidence 0.23 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604887 Disease Relevance 0.44 Pain Relevance 0.27
The author received a small grant for Serono to study the permeability of the BBB to breaker peptides.
BBB Binding (permeability) of
9) Confidence 0.23 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604887 Disease Relevance 0.82 Pain Relevance 0.18
Special characteristics of the disease may aid or impede drug delivery, and the ligand can be modified to cross the BBB, which itself may be modified by the disease [2-4].
BBB Binding (cross) of associated with disease
10) Confidence 0.23 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604887 Disease Relevance 0.38 Pain Relevance 0.22
Besides the physical barrier of the endothelial cell wall, there are the following obstacles: protein binding in the circulation; enzymatic degradation in the circulation, at the BBB, or within the CNS; uptake or sequestration by peripheral tissues of the peripherally administered substance; sequestration by the capillaries that comprise the BBB; and efflux, or removal, by CNS-to-blood transporters.
BBB Binding (binding) of in endothelial cell associated with central nervous system
11) Confidence 0.23 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604887 Disease Relevance 0 Pain Relevance 0.21
Immune cells cross the BBB by a vesicular related process: diapedesis.
BBB Binding (cross) of in Immune cells
12) Confidence 0.23 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604887 Disease Relevance 0 Pain Relevance 0.42
amyloid protein region of amyloid precursor protein can cross the BBB, reduce levels of ?
BBB Binding (cross) of associated with alzheimer's dementia
13) Confidence 0.23 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604887 Disease Relevance 0.89 Pain Relevance 0.24
Normally, Trypan blue does not cross the BBB because of its size (MW, 916 Da) and hydrophilicity (4 sulfonic acid groups).
BBB Neg (not) Binding (cross) of
14) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2364662 Disease Relevance 0.63 Pain Relevance 0.05
Many large biological molecules, such as antibodies and siRNA, cannot be easily modified to cross the BBB passively.
BBB Binding (cross) of
15) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2364662 Disease Relevance 0.16 Pain Relevance 0.04
We suggest that such a system could feasibly be used at low powers to achieve noninvasive BBB disruption with high spatial resolution for targeted FUS-MB delivery.
BBB Binding (disruption) of
16) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2364662 Disease Relevance 0.38 Pain Relevance 0.13
permeation across the BBB into the brain and fast washout from the normal brain
BBB Binding (across) of in brain
17) Confidence 0.16 Published 2007 Journal International Journal of Biomedical Imaging Section Body Doc Link PMC2267214 Disease Relevance 0.55 Pain Relevance 0.20
across the BBB but also accumulate in the brain ischemia.
BBB Binding (across) of in brain associated with brain hemorrhage and ischemia
18) Confidence 0.16 Published 2007 Journal International Journal of Biomedical Imaging Section Body Doc Link PMC2267214 Disease Relevance 0.92 Pain Relevance 0.44
across the BBB into the brain at the early stage postinjection but also fast
BBB Binding (across) of in brain
19) Confidence 0.16 Published 2007 Journal International Journal of Biomedical Imaging Section Body Doc Link PMC2267214 Disease Relevance 0.20 Pain Relevance 0.10
The risk of a drug interaction at the BBB is also increased if one transporter dominates the transport.
BBB Binding (interaction) of
20) Confidence 0.14 Published 2007 Journal Pharm Res Section Body Doc Link PMC2469271 Disease Relevance 0 Pain Relevance 0

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