INT36186

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Context Info
Confidence 0.75
First Reported 1988
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.09
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy, Gnrh1) extracellular region (Npy, Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
juvenile 2
anterior pituitary 2
Npy (Rattus norvegicus)
Gnrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
excitatory amino acid 1 99.88 Very High Very High Very High
noradrenaline 2 99.40 Very High Very High Very High
agonist 24 96.28 Very High Very High Very High
Neuropeptide 14 95.08 Very High Very High Very High
Endogenous opioid 2 90.40 High High
Opioid 4 89.40 High High
Kinase C 1 16.20 Low Low
antagonist 39 5.00 Very Low Very Low Very Low
Nerve growth factor 28 5.00 Very Low Very Low Very Low
Inflammation 27 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 22 85.36 High High
Stress 48 5.00 Very Low Very Low Very Low
INFLAMMATION 28 5.00 Very Low Very Low Very Low
Cancer 22 5.00 Very Low Very Low Very Low
Pituitary Cancer 11 5.00 Very Low Very Low Very Low
Starvation 10 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low
Natriuresis 7 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low
Hyperplasia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the hypothalamic level, NPY stimulates luteinizing hormone releasing hormone (LHRH) release, a response mediated by alpha 2-adrenoreceptors and amplified in the presence of adrenergic agonists.
NPY Positive_regulation (stimulates) of Localization (release) of LHRH associated with agonist
1) Confidence 0.75 Published 1988 Journal J. Steroid Biochem. Section Abstract Doc Link 3290580 Disease Relevance 0 Pain Relevance 0.39
At the hypothalamic level, NPY stimulates luteinizing hormone releasing hormone (LHRH) release, a response mediated by alpha 2-adrenoreceptors and amplified in the presence of adrenergic agonists.
NPY Positive_regulation (stimulates) of Localization (release) of releasing hormone associated with agonist
2) Confidence 0.47 Published 1988 Journal J. Steroid Biochem. Section Abstract Doc Link 3290580 Disease Relevance 0 Pain Relevance 0.39
There is a concomitant increase in excitatory inputs, mainly noradrenaline, excitatory amino acids, and NPY, which increase the synthesis and release of GnRH at the beginning of the juvenile period and participate in the coupling of GnRH neural activity to the ongoing rhythmic activity of a hypothalamic circadian oscillator. 4.
NPY Positive_regulation (increase) of Localization (release) of GnRH in juvenile associated with noradrenaline and excitatory amino acid
3) Confidence 0.37 Published 1995 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 7648607 Disease Relevance 0 Pain Relevance 0.19
In vitro, NPY augments GnRH-stimulated LH secretion from anterior pituitary removed from pro-oestrous, but not metoestrous, rats (542).
NPY Positive_regulation (augments) of Localization (secretion) of GnRH in anterior pituitary
4) Confidence 0.07 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.09 Pain Relevance 0

General Comments

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