INT36192

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Context Info
Confidence 0.70
First Reported 1983
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 2.95
Pain Relevance 3.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
LLCs 2
placentas 1
HTC2 (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 6 99.74 Very High Very High Very High
MU agonist 10 99.56 Very High Very High Very High
Dynorphin 6 99.34 Very High Very High Very High
methadone 6 98.88 Very High Very High Very High
opioid receptor 7 97.48 Very High Very High Very High
Opioid 7 96.92 Very High Very High Very High
Endogenous opioid 3 96.88 Very High Very High Very High
anesthesia 2 95.12 Very High Very High Very High
narcan 6 94.04 High High
antagonist 3 93.64 High High
Disease Link Frequency Relevance Heat
Disease 25 99.36 Very High Very High Very High
Premature Ventricular Beats 4 94.40 High High
Reprotox - General 1 9 92.20 High High
Nasopharynx Cancer 103 89.44 High High
Germ Cell And Embryonal Neoplasms 3 80.52 Quite High
Dysgerminoma 2 78.12 Quite High
Residual Neoplasm 2 77.20 Quite High
Malignant Neoplastic Disease 8 75.00 Quite High
Endodermal Sinus Tumor 3 74.80 Quite High
Cancer 49 73.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This fact favours the hypothesis of a participation of placental opiate receptor on hCG secretion.
Localization (secretion) of hCG associated with opiate
1) Confidence 0.70 Published 1983 Journal Life Sci. Section Abstract Doc Link 6141498 Disease Relevance 0 Pain Relevance 0.36
Ethylketocyclazocine stimulate K+-induced hCG release.
Localization (release) of hCG
2) Confidence 0.70 Published 1983 Journal Life Sci. Section Abstract Doc Link 6141498 Disease Relevance 0 Pain Relevance 0.37
Placental kappa binding site : interaction with dynorphin and its possible implication in hCG secretion.
Localization (secretion) of hCG associated with dynorphin
3) Confidence 0.70 Published 1983 Journal Life Sci. Section Title Doc Link 6141498 Disease Relevance 0 Pain Relevance 0.36
There was an initial rapid decline in hCG excretion (t1/2 48 h), reaching 10% of the pre-treatment value after 6 days.
Localization (excretion) of hCG
4) Confidence 0.52 Published 1988 Journal Acta Endocrinol. Section Abstract Doc Link 3291533 Disease Relevance 0.25 Pain Relevance 0.09
The urinary excretion of hCG, total estrogen and pregnanediol was similar in each group.
Localization (excretion) of hCG
5) Confidence 0.49 Published 1988 Journal Acta Endocrinol. Section Abstract Doc Link 3291533 Disease Relevance 0.26 Pain Relevance 0.10
In vitro release of acetylcholine and hCG from trophoblast tissue of methadone-exposed placentas was not modulated by opioids.
Localization (release) of hCG in placentas associated with methadone and opioid
6) Confidence 0.46 Published 1993 Journal Membr Biochem Section Abstract Doc Link 8395641 Disease Relevance 0 Pain Relevance 0.91
multiple experimental applications (e.g., CGH, LOH, and expression microarray) at
Localization (applications) of CGH
7) Confidence 0.21 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 0.66 Pain Relevance 0
However, FK 33-824 completely abolished the stimulatory effect of hCG on P4 secretion by SLCs.
Localization (secretion) of hCG
8) Confidence 0.03 Published 1999 Journal Anim. Reprod. Sci. Section Abstract Doc Link 10497920 Disease Relevance 0 Pain Relevance 0.44
As regards cGMP output, only LLCs showed elevated secretion of this cyclic nucleotide under the influence of hCG.
Localization (secretion) of hCG in LLCs
9) Confidence 0.03 Published 1999 Journal Anim. Reprod. Sci. Section Abstract Doc Link 10497920 Disease Relevance 0 Pain Relevance 0.36
The present study was designed to investigate the effect of the opioid agonist FK 33-824 on basal and hCG-induced progesterone (P4), cAMP and cGMP secretion and on the phosphoinositide-specific phospholipase C signalling system in separated porcine small (SLCs) and large luteal cells (LLCs).
Localization (secretion) of hCG in LLCs associated with mu agonist
10) Confidence 0.03 Published 1999 Journal Anim. Reprod. Sci. Section Abstract Doc Link 10497920 Disease Relevance 0 Pain Relevance 0.25
As long as AFP or hCG or both can be used to monitor the disease in patients positive for these sensitive and reliable markers, or in an early stage with complete resection, second-look laparotomy is not useful.
Localization (used) of hCG associated with disease
11) Confidence 0.01 Published 1995 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 7661594 Disease Relevance 1.78 Pain Relevance 0.06

General Comments

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