INT36200

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Context Info
Confidence 0.77
First Reported 1988
Last Reported 2010
Negated 6
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 9.56
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (S100A1) intracellular (S100A1) protein complex (S100A1)
cytoplasm (S100A1)
Anatomy Link Frequency
smooth muscle 1
muscle 1
lung 1
Schwann cells 1
renal vein 1
S100A1 (Homo sapiens)
S100A1 - S100A (1)
Pain Link Frequency Relevance Heat
Inflammation 4 90.56 High High
Sciatic nerve 1 88.64 High High
imagery 6 86.48 High High
Pain 6 80.12 Quite High
pain pelvic 1 67.72 Quite High
backache 1 64.56 Quite High
shoulder pain 1 62.16 Quite High
COX2 3 55.28 Quite High
Neuritis 1 51.92 Quite High
Kinase C 1 40.36 Quite Low
Disease Link Frequency Relevance Heat
Chordoma 9 99.86 Very High Very High Very High
Cancer 114 98.48 Very High Very High Very High
Recurrence 18 97.88 Very High Very High Very High
Leiomyosarcoma 3 97.64 Very High Very High Very High
Stomach Cancer 1 97.32 Very High Very High Very High
Carcinoma 2 97.28 Very High Very High Very High
Lung Cancer 2 96.60 Very High Very High Very High
Pancreatic Cancer 1 96.08 Very High Very High Very High
Malignant Neoplastic Disease 18 95.84 Very High Very High Very High
Sarcoma 13 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nerve structures were detected by automatic immunostaining techniques using a polyclonal antibody against two S-100 proteins that reacts strongly with human S100A and B that are detected in Schwann cells.
Gene_expression (detected) of S100A (S100A) in Schwann cells
1) Confidence 0.77 Published 2008 Journal Neuroscience Section Abstract Doc Link 18538483 Disease Relevance 0.08 Pain Relevance 0.08
Chordomas cells express epithelial differentiation antigens (low molecular weight cytokeratins, EMA, CAM 52, HFM 62, even CEA), Vimentin and S-100 Protein: this triple positivity allow differentiation between chordomas and numerous others tumors.
Gene_expression (express) of S-100 Protein associated with cancer and chordoma
2) Confidence 0.75 Published 1988 Journal Ann Pathol Section Abstract Doc Link 3293577 Disease Relevance 1.18 Pain Relevance 0.07
The S100 family bind to p53 and regulate the oligomerization of p53.41 Copy number gain and high expression of the S100 family is reported in relation with progression and recurrence of stomach cancer,42 lung cancer, pancreatic cancer and brain tumor.42,43 This suggests that S100A2 is likely to be linked with CRC.
Gene_expression (expression) of S100 in lung associated with lung cancer, colon cancer, pancreatic cancer, brain tumor, stomach cancer and recurrence
3) Confidence 0.75 Published 2010 Journal Cancer Informatics Section Body Doc Link PMC2918356 Disease Relevance 1.33 Pain Relevance 0.08
Immunohistochemistry of the tumour showed smooth muscle actin (SMA) to be focally positive, but Desmin, CD34, S-100, Neurofilament, EMA, CAM 5.2, CD117, CD21 and CD23 were negative.
Neg (negative) Gene_expression (negative) of S-100 in smooth muscle associated with cancer
4) Confidence 0.75 Published 2006 Journal Int Semin Surg Oncol Section Body Doc Link PMC1513591 Disease Relevance 1.56 Pain Relevance 0.11
Histologically, pseudo-onion bulbs composed of epithelial membrane antigen-reactive, S-100 protein-negative perineurial cells surrounded myelinated or nonmyelinated nerve fibers.
Neg (negative) Gene_expression (negative) of S-100 protein in bulbs
5) Confidence 0.65 Published 1995 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 7785653 Disease Relevance 0.80 Pain Relevance 0.10
Immunohistochemical examinations were consistently negative for actin, desmin, S 100-protein, Bcl 2 and cytokeratins 7 and 19.
Neg (negative) Spec (examinations) Gene_expression (negative) of S 100-protein,
6) Confidence 0.65 Published 2008 Journal Head Face Med Section Body Doc Link PMC2556660 Disease Relevance 1.14 Pain Relevance 0.04
Histochemical stains showed strong positive staining with muscle actin, positive staining with CD34 and weak positive staining with CD117, while it was negative for S-100.
Neg (negative) Gene_expression (negative) of S-100 in muscle
7) Confidence 0.58 Published 2004 Journal World J Surg Oncol Section Body Doc Link PMC419373 Disease Relevance 1.15 Pain Relevance 0.10
Pathological examination showed a well differentiated leiomyosarcoma arising from the renal vein; the tumor cells stained positive for alpha-smooth muscle actin, vimentin and desmin and negative for S 100-protein.
Neg (negative) Gene_expression (negative) of S 100-protein in renal vein associated with leiomyosarcoma and cancer
8) Confidence 0.58 Published 2001 Journal Nippon Hinyokika Gakkai Zasshi Section Abstract Doc Link 11235142 Disease Relevance 0.81 Pain Relevance 0.11
S-100 protein, SMA and GFAP were negative.
Neg (negative) Gene_expression (negative) of S-100 protein
9) Confidence 0.48 Published 2003 Journal Pathol. Int. Section Abstract Doc Link 14516322 Disease Relevance 1.50 Pain Relevance 0.06
The co-expression of S100A1 was expected, based on results by others [41].
Gene_expression (expression) of S100A1
10) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937027 Disease Relevance 0 Pain Relevance 0

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