INT36212

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Context Info
Confidence 0.61
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 12.31
Pain Relevance 9.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Csad) cellular_component (Csad)
Anatomy Link Frequency
neuronal 2
TVS 1
capsule 1
Neuron 1
Csad (Mus musculus)
Pain Link Frequency Relevance Heat
depression 57 100.00 Very High Very High Very High
Glutamate 8 100.00 Very High Very High Very High
Anterior cingulate cortex 201 99.68 Very High Very High Very High
primary somatosensory cortex 168 99.68 Very High Very High Very High
Morphine 264 99.48 Very High Very High Very High
Migraine 48 99.34 Very High Very High Very High
Pain 48 98.96 Very High Very High Very High
headache 4 97.08 Very High Very High Very High
interneuron 4 96.96 Very High Very High Very High
Enkephalin 99 96.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 57 100.00 Very High Very High Very High
Headache 26 99.34 Very High Very High Very High
Pain 38 98.96 Very High Very High Very High
Migraine With Aura 13 98.92 Very High Very High Very High
Migraine Disorders 10 98.68 Very High Very High Very High
Nociception 90 98.44 Very High Very High Very High
Epilepsy 13 98.32 Very High Very High Very High
Targeted Disruption 289 97.72 Very High Very High Very High
Stress 10 95.36 Very High Very High Very High
Lymphadenopathy 3 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using two different methods for induction of CSD, we found that female mice had a significantly reduced threshold for induction of CSD compared with male mice.
Positive_regulation (induction) of CSD associated with depression
1) Confidence 0.61 Published 2007 Journal Ann. Neurol. Section Abstract Doc Link 17474110 Disease Relevance 0.91 Pain Relevance 0.64
We would also advise that in those cases of parotid CSD in which either the diagnosis is equivocal, CS antigen is unavailable or intense parotid pain is a predominant feature, excision of the primary lesion together with surgical decompression of the parotid capsule should be performed.
Positive_regulation (cases) of CSD in capsule associated with pain
2) Confidence 0.43 Published 1988 Journal J Laryngol Otol Section Abstract Doc Link 3294321 Disease Relevance 0.67 Pain Relevance 0.35
Knockin mice carrying a FHM1 mutation show increased neuronal P/Q-type current and facilitation of induction and propagation of cortical spreading depression (CSD), the phenomenon that underlies migraine aura and may activate migraine headache mechanisms.
Positive_regulation (increased) of CSD in neuronal associated with epilepsy, depression, migraine and headache
3) Confidence 0.42 Published 2009 Journal Neuron Section Abstract Doc Link 19285472 Disease Relevance 1.13 Pain Relevance 0.98
Occipital sites for CSD induction are clearly optimal for this purpose.
Positive_regulation (induction) of CSD associated with depression
4) Confidence 0.41 Published 2001 Journal J. Neurophysiol. Section Abstract Doc Link 11600666 Disease Relevance 0.99 Pain Relevance 0.65
In this issue of Neuron, van den Maagdenberg et al. characterize a mouse with a knockin mutation known to cause familial hemiplegic migraine and provide evidence that a lowered threshold to the triggering of CSD may account for the devastating phenotype of familial hemiplegic migraine.
Positive_regulation (triggering) of CSD in Neuron associated with migraine with aura and migraine
5) Confidence 0.41 Published 2004 Journal Neuron Section Abstract Doc Link 15003166 Disease Relevance 0.76 Pain Relevance 0.36
Using two different methods for induction of CSD, we found that female mice had a significantly reduced threshold for induction of CSD compared with male mice.
Positive_regulation (induction) of CSD associated with depression
6) Confidence 0.41 Published 2007 Journal Ann. Neurol. Section Abstract Doc Link 17474110 Disease Relevance 0.89 Pain Relevance 0.62
The FHM1 knockin mice show allele dosage-dependent gain-of-function of neuronal P/Q-type Ca2+ current, reflecting activation of mutant channels at lower voltages, and allele dosage- and sex-dependent facilitation of induction and propagation of cortical spreading depression (CSD), the phenomenon that underlies migraine aura.
Positive_regulation (induction) of CSD in neuronal associated with epilepsy, depression and migraine
7) Confidence 0.40 Published 2010 Journal J. Physiol. (Lond.) Section Abstract Doc Link 20194127 Disease Relevance 1.18 Pain Relevance 0.91
Morphine (10 mg/kg) significantly increased the evoked CSD response (sink 2) in layer V of the ACC (Figure 8A &8B, KO mice, n = 4, p = 0.01; WT mice, n = 4, p = 0.05).
Positive_regulation (increased) of CSD associated with targeted disruption, anterior cingulate cortex and morphine
8) Confidence 0.24 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.50 Pain Relevance 1.63
Evidence for a causative link between enhanced glutamate release and CSD facilitation was obtained.
Positive_regulation (enhanced) of CSD associated with glutamate and depression
9) Confidence 0.22 Published 2010 Journal J. Physiol. (Lond.) Section Abstract Doc Link 20194127 Disease Relevance 1.27 Pain Relevance 1.17
Using an in vitro model of CSD, we show a causative link between enhanced glutamate release and CSD facilitation.
Positive_regulation (enhanced) of CSD associated with glutamate and depression
10) Confidence 0.21 Published 2009 Journal Neuron Section Abstract Doc Link 19285472 Disease Relevance 1.02 Pain Relevance 1.06
Laser evoked CSD in the S1
Positive_regulation (evoked) of CSD associated with primary somatosensory cortex
11) Confidence 0.17 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.92 Pain Relevance 0.45
Electrical stimulation evoked CSD in the ACC
Positive_regulation (evoked) of CSD associated with anterior cingulate cortex
12) Confidence 0.17 Published 2008 Journal Mol Pain Section Body Doc Link PMC2569012 Disease Relevance 0.43 Pain Relevance 0.23
Trigemino-vascular system (TVS) activation is believed to play a crucial role in the "pain phase" in migraine; cortical spreading depression (CSD) is considered to be the primary cause of TVS activation.
Positive_regulation (activation) of CSD in TVS associated with pain, depression and migraine
13) Confidence 0.04 Published 2009 Journal Seizure Section Abstract Doc Link 19223208 Disease Relevance 1.61 Pain Relevance 0.90

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