INT36221

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Context Info
Confidence 0.68
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 25
Total Number 28
Disease Relevance 19.70
Pain Relevance 4.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Nlrp3)
Anatomy Link Frequency
macrophages 2
articular 1
proximal 1
cleavage 1
body 1
Nlrp3 (Mus musculus)
Pain Link Frequency Relevance Heat
depression 2 99.44 Very High Very High Very High
Inflammation 673 99.40 Very High Very High Very High
ischemia 40 99.18 Very High Very High Very High
Inflammatory response 95 98.40 Very High Very High Very High
cytokine 213 98.08 Very High Very High Very High
chemokine 52 96.48 Very High Very High Very High
Angina 8 96.36 Very High Very High Very High
fibrosis 9 95.12 Very High Very High Very High
antagonist 13 84.72 Quite High
anakinra 77 83.12 Quite High
Disease Link Frequency Relevance Heat
Disease 255 100.00 Very High Very High Very High
Apoptosis 73 100.00 Very High Very High Very High
Cryopyrin-associated Periodic Syndromes 54 99.72 Very High Very High Very High
Reperfusion Injury 12 99.56 Very High Very High Very High
Depression 2 99.44 Very High Very High Very High
Crystal Associated Disease 694 99.34 Very High Very High Very High
Adenovirus Infection 3 99.24 Very High Very High Very High
Salmonella Infection 7 98.72 Very High Very High Very High
INFLAMMATION 775 98.68 Very High Very High Very High
Syndrome 63 97.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Wanderer) that these pathophysiologic conditions cause an increase in byproducts (DAMPs) from breakdown of cellular nucleotides or proteins, which could stimulate innate receptors such as NLRP3 to cause secretion of IL-1?
Positive_regulation (stimulate) of NLRP3
1) Confidence 0.68 Published 2010 Journal Curr Allergy Asthma Rep Section Body Doc Link PMC2892083 Disease Relevance 1.38 Pain Relevance 0.26
The group of Tschopp discovered that many inorganic particles, including MSU and calcium pyrophosphate dihydrate crystals, are capable of activating the NLRP3 inflammasome to process and secrete active IL-1?
Positive_regulation (activating) of NLRP3 associated with crystal associated disease
2) Confidence 0.61 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 0.43 Pain Relevance 0.03
In addition, NLRP3 can be activated by signals that induce potassium efflux, such as ATP, via the P2X7 receptor, or by toxins such as nigericin.
Positive_regulation (activated) of NLRP3
3) Confidence 0.61 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 0.21 Pain Relevance 0.03
Our studies provide the first evidence for a role of tyrosine kinase signaling molecules in NLRP3 activation.
Positive_regulation (activation) of NLRP3
4) Confidence 0.60 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
While a number of stimuli are known to activate the NLRP3 inflammasome, there is no evidence that NLRP3 directly recognizes these ligands.
Positive_regulation (activate) of NLRP3
5) Confidence 0.60 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
Spontaneous activation of the NALP3 inflammasome due to mutations in the NALP3 gene has been implicated in hereditary autoinflammatory syndromes such as Muckle–Wells syndrome and chronic infantile neurologic cutaneous articular [11].
Positive_regulation (activation) of NALP3 in articular associated with syndrome
6) Confidence 0.60 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906806 Disease Relevance 0.70 Pain Relevance 0.13
However, further study will be necessary to better characterize these regulatory events in regards to the different inorganic crystals that can trigger NLRP3 inflammasome activation.
Positive_regulation (activation) of NLRP3
7) Confidence 0.52 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
The recent finding that MSU crystals induce IL-1 release by activation of the NALP3 inflammasome led us to investigate whether IL-1 blockade could inhibit inflammation provoked by MSU.
Positive_regulation (activation) of NALP3 associated with inflammation and crystal associated disease
8) Confidence 0.52 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906806 Disease Relevance 1.05 Pain Relevance 0.40
Gasse et al. [15] studied a murine model and established that bleomycin effects occur via uric acid/urate formation and stimulation of the NLRP3 inflammasome, leading to IL-1?
Positive_regulation (stimulation) of NLRP3
9) Confidence 0.49 Published 2010 Journal Curr Allergy Asthma Rep Section Body Doc Link PMC2892083 Disease Relevance 1.68 Pain Relevance 0.43
A constitutively active form of mutated NALP3/cryopyrin, which promotes IL-1?
Positive_regulation (mutated) of cryopyrin
10) Confidence 0.49 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.02 Pain Relevance 0.26
One such paradigm is the production of DAMPs formation from the pathobiological effects of ischemia reperfusion injury, which in turn could stimulate NLRP3 and cause IL-1?
Positive_regulation (stimulate) of NLRP3 associated with ischemia
11) Confidence 0.46 Published 2010 Journal Curr Allergy Asthma Rep Section Body Doc Link PMC2892083 Disease Relevance 1.18 Pain Relevance 0.32
Trx plays an important role in activation of the NLRP3 inflammasome responsible for activation of the cytokine interleukin 1?
Positive_regulation (activation) of NLRP3 associated with cytokine
12) Confidence 0.45 Published 2010 Journal Biol Trace Elem Res Section Body Doc Link PMC2855032 Disease Relevance 0.82 Pain Relevance 0.47
These effects were absent following treatment with empty viral capsids or extracellular adenoviral DNA, indicating that neither virion internalization alone nor extracellular DNA could trigger the inflammasome [93, 95].A closer examination of inflammasome components revealed that the cytoplasmic receptor NALP3 (NATCHT-, leucine-rich-repeat- and pyrin-domain-containing protein 3; also known as NLRP3 or cryopyrin) and its adaptor protein, ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain-CARD), are essential for sensing viral DNA, as macrophages from mice deficient in either of these proteins had significantly reduced inflammasome activation in response to adenoviruses.
Positive_regulation (activation) of cryopyrin in macrophages associated with apoptosis
13) Confidence 0.45 Published 2010 Journal Autoimmune Diseases Section Body Doc Link PMC2989704 Disease Relevance 0.33 Pain Relevance 0.04
A body of research from the 1990s showed that protein coating modified crystal-induced inflammation - but how does this work, and how do we integrate this with the more recent data on NLRP3 activation?
Positive_regulation (activation) of NLRP3 in body associated with inflammation
14) Confidence 0.44 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888190 Disease Relevance 0.64 Pain Relevance 0.15
Pyrin domains are known to mediate protein-protein interactions and are crucial in many of the NLR inflammasome complexes, and in particular, mediate the NLRP3 and ASC interaction [6].
Positive_regulation (mediate) of NLRP3
15) Confidence 0.43 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
Although much has been discovered regarding the NLRP3 inflammasome induction, the mechanism whereby this intracellular multimolecular complex is activated remains unclear.
Positive_regulation (induction) of NLRP3
16) Confidence 0.40 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2722371 Disease Relevance 0.55 Pain Relevance 0.08
To evaluate whether activation of the NLRP3 inflammasome is involved in Hz-induced inflammatory responses in vivo, mice were injected intraperitoneally with Hz and then neutrophil recruitment to the site of injection was examined.
Spec (whether) Positive_regulation (activation) of NLRP3 in neutrophil associated with inflammatory response
17) Confidence 0.40 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.27 Pain Relevance 0.08
However, it is still unclear how this enzyme is involved in inflammasome activation and indeed, many of the proximal signaling events in NLRP3 and NLR activation remain unknown.


Positive_regulation (activation) of NLRP3 in proximal
18) Confidence 0.40 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.20 Pain Relevance 0
Compared to them captopril augmented the MWT, increased the MWS, reduced S-T depression at MRPP, and decreased the number of patients with effort-induced angina pectoris.
Positive_regulation (increased) of MWS associated with angina and depression
19) Confidence 0.40 Published 1987 Journal Cardiology Section Abstract Doc Link 3297325 Disease Relevance 0.53 Pain Relevance 0.35
from silica and asbestos stimulation of the NLRP3 inflammasome [17].
Positive_regulation (stimulation) of NLRP3
20) Confidence 0.40 Published 2010 Journal Curr Allergy Asthma Rep Section Body Doc Link PMC2892083 Disease Relevance 1.39 Pain Relevance 0.31

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