INT36226

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Context Info
Confidence 0.67
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 3.05
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GIP) small molecule metabolic process (GIP) extracellular region (GIP)
cytoplasm (GIP)
Anatomy Link Frequency
endocrine cells 3
plasma 2
duodenum 2
pancreatic islets 1
GIP (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 2 100.00 Very High Very High Very High
Cholecystokinin 1 99.18 Very High Very High Very High
Calcitonin gene-related peptide 1 94.96 High High
nud 3 94.92 High High
Opioid 1 94.56 High High
potassium channel 16 93.96 High High
adenocard 17 86.76 High High
Enkephalin 1 84.80 Quite High
Neuropeptide 35 79.48 Quite High
agonist 31 77.04 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 498 99.54 Very High Very High Very High
Obesity 44 98.52 Very High Very High Very High
Dyspepsia 3 94.92 High High
Cancer 10 91.20 High High
Hyperinsulinism 10 82.48 Quite High
Hyperglycemia 41 67.92 Quite High
Pancreatitis 5 50.00 Quite Low
Apoptosis 8 49.36 Quite Low
Cardiovascular Disease 24 42.88 Quite Low
Body Weight 39 38.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both GIP and GLP-1 receptors are expressed in various tissues.
Gene_expression (expressed) of GIP
1) Confidence 0.67 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597770 Disease Relevance 0.08 Pain Relevance 0.18
Gastrin, xenopsin, cholecystokinin (CCK), somatostatin, motilin, secretin, GIP (gastric inhibitory polypeptide), neurotensin, glicentin/glucagon-37 and PYY (peptide tyrosine tyrosine) are the main products of gastrointestinal endocrine cells; glucagon, CRF (corticotropin releasing factor), somatostatin, PP (pancreatic polypeptide) and GRF (growth hormone releasing factor), in addition to insulin, are produced in pancreatic islet cells; bombesin-related peptides are the main markers of pulmonary endocrine cells; calcitonin and CGRP (calcitonin gene-related peptide) occur in thyroid and extrathyroid C cells; ACTH and endorphins in anterior and intermediate lobe pituitary cells, alpha-MSH and CLIP (corticotropin-like intermediate lobe peptide) in intermediate lobe cells; met- and leu-enkephalins and related peptides in adrenal medullary and paraganglionic cells as well as in some gut (enterochromaffin) cells; NPY (neuropeptide Y) in adrenaline-type adrenal medullary cells, etc..
Gene_expression (produced) of GIP in endocrine cells associated with neuropeptide, somatostatin, enkephalin, cholecystokinin and calcitonin gene-related peptide
2) Confidence 0.65 Published 1987 Journal Experientia Section Abstract Doc Link 3297770 Disease Relevance 0.09 Pain Relevance 0.42
METHODS: Responses of the GI hormone glucose-dependent insulinotropic polypeptide (GIP) and GLP-2 were measured following an 80-min liquid meal test in 8 patients (6 males) with chronic pancreatitis (CP) and pancreatic exocrine insufficiency (PEI) and 8 healthy control subjects (5 males).
Gene_expression (measured) of GIP
3) Confidence 0.65 Published 2010 Journal Pancreatology Section Body Doc Link 20460948 Disease Relevance 0 Pain Relevance 0
In protocol 2, no difference was seen in the plasma TAG on Intralipid + GIP/saline and Intralipid + glucose + GIP/saline days.
Gene_expression (saline) of GIP in plasma
4) Confidence 0.58 Published 2010 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 19996386 Disease Relevance 0.17 Pain Relevance 0.12
In protocol 2, no difference was seen in the plasma TAG on Intralipid + GIP/saline and Intralipid + glucose + GIP/saline days.
Gene_expression (saline) of GIP in plasma
5) Confidence 0.58 Published 2010 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 19996386 Disease Relevance 0.18 Pain Relevance 0.12
GLP-1 receptors are found in pancreatic islets, vagal nerves, stomach, lung, kidney, and the brain, whereas GIP receptors are expressed in pancreatic islets, the brain and adipose tissue (Mayo et al 2003; Wideman and Kieffer 2004).
Gene_expression (expressed) of GIP in pancreatic islets associated with obesity
6) Confidence 0.58 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597770 Disease Relevance 0.10 Pain Relevance 0.16
Patients with type 2 diabetes exhibit an attenuated insulinotropic action of GIP but not GLP-1 and a significant reduction in meal-stimulated levels of GLP-1 (Nauck et al 1993; Toft-Nielsen et al 2001).
Gene_expression (action) of GIP associated with diabetes mellitus
7) Confidence 0.58 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597770 Disease Relevance 0.31 Pain Relevance 0.04
However, L-cells are also found in the duodenum and endocrine cells also co-express GLP-1 and GIP (Mortensen et al 2003).
Gene_expression (-) of GIP in endocrine cells
8) Confidence 0.52 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597770 Disease Relevance 0.34 Pain Relevance 0.03
However, L-cells are also found in the duodenum and endocrine cells also co-express GLP-1 and GIP (Mortensen et al 2003).
Gene_expression (express) of GIP in endocrine cells
9) Confidence 0.52 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597770 Disease Relevance 0.34 Pain Relevance 0.03
Patients with type 2 diabetes exhibit an attenuated insulinotropic action of GIP but not GLP-1 and a significant reduction in meal-stimulated levels of GLP-1 (Nauck et al 1993; Toft-Nielsen et al 2001).
Gene_expression (action) of insulinotropic associated with diabetes mellitus
10) Confidence 0.50 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597770 Disease Relevance 0.31 Pain Relevance 0.04
Conversely, hyperglycaemia acutely reduces the postprandial levels of GIP and GLP-1, possibly through a deceleration of gastric emptying.
Gene_expression (levels) of GIP
11) Confidence 0.24 Published 2010 Journal Pediatr Nephrol Section Body Doc Link PMC2874027 Disease Relevance 0.45 Pain Relevance 0.05
However, L-cells are also found in the duodenum and endocrine cells also co-express GLP-1 and GIP (Mortensen et al 2003).
Gene_expression (-) of GIP in duodenum
12) Confidence 0.18 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597770 Disease Relevance 0.34 Pain Relevance 0.03
However, L-cells are also found in the duodenum and endocrine cells also co-express GLP-1 and GIP (Mortensen et al 2003).
Gene_expression (express) of GIP in duodenum
13) Confidence 0.18 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597770 Disease Relevance 0.34 Pain Relevance 0.03

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