INT36245

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Context Info
Confidence 0.40
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 5.32
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ELANE) extracellular region (ELANE) cytoplasm (ELANE)
Anatomy Link Frequency
neutrophil 6
chondrocytes 2
liver 2
ELANE (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 88 99.84 Very High Very High Very High
diclofenac 12 99.84 Very High Very High Very High
Inflammation 275 98.72 Very High Very High Very High
cytokine 98 88.72 High High
Paracetamol 8 88.28 High High
qutenza 2 83.68 Quite High
cINOD 5 80.48 Quite High
fibrosis 78 76.96 Quite High
Prostatitis 21 71.72 Quite High
Inflammatory response 52 67.28 Quite High
Disease Link Frequency Relevance Heat
Stress 453 100.00 Very High Very High Very High
Shock 27 100.00 Very High Very High Very High
Osteoarthritis 96 99.84 Very High Very High Very High
Injury 185 99.70 Very High Very High Very High
INFLAMMATION 326 98.72 Very High Very High Very High
Disease 83 96.60 Very High Very High Very High
Liver Disease 172 92.96 High High
Infection 48 83.04 Quite High
Cirrhosis 180 77.44 Quite High
Prostatitis 21 71.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Values <250 ng/ml were regarded as decreased elastase levels.
Negative_regulation (decreased) of Gene_expression (levels) of elastase
1) Confidence 0.40 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2778713 Disease Relevance 0.73 Pain Relevance 0.21
Neutrophil elastase and neutrophil elastase inhibitor assays
Negative_regulation (inhibitor) of Gene_expression (assays) of elastase in neutrophil
2) Confidence 0.24 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2706618 Disease Relevance 0 Pain Relevance 0.03
Neutrophil elastase and neutrophil elastase inhibitor assays
Negative_regulation (inhibitor) of Gene_expression (assays) of elastase in neutrophil
3) Confidence 0.24 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2706618 Disease Relevance 0 Pain Relevance 0.03
The PMN production of superoxide anion induced by various FMLP concentrations (10(-7), 10(-6) and 10(-5) M) was also decreased by diclofenac.
Negative_regulation (decreased) of Gene_expression (production) of PMN in PMN associated with diclofenac
4) Confidence 0.16 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 3300657 Disease Relevance 0.08 Pain Relevance 0.42
In this context, a drug that inhibits HNE production may be beneficial to attenuate inflammation in the treatment of OA and inflammatory diseases.


Negative_regulation (inhibits) of Gene_expression (production) of HNE associated with inflammation, disease and osteoarthritis
5) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.97 Pain Relevance 0.46
Using the nonspecific inhibitor of COX, naproxen, we abolished HNE-induced FLAP expression in OA chondrocytes after short or long periods of incubation.
Negative_regulation (abolished) of Gene_expression (expression) of HNE-induced in chondrocytes associated with osteoarthritis
6) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.28 Pain Relevance 0.14
To assess the importance of the heat shock response in mediating the cellular response to electrophile stress, siRNA was used to silence HSF1, thereby attenuating heat shock gene expression in HNE-treated cells.(27) Control and HSF1-deficient cells were then exposed to HNE, and various responses measured including viability and gene expression changes. siRNA knockdown of HSF1 was nearly complete, and residual expression of the transcription factor was vanishingly small.
Negative_regulation (attenuating) of Gene_expression (expression) of HNE associated with stress and shock
7) Confidence 0.14 Published 2010 Journal Accounts of Chemical Research Section Body Doc Link PMC2873822 Disease Relevance 0.50 Pain Relevance 0
M [188]; in the CCl4 model of oxidative stress-related acute liver injury, intrahepatic levels of HNE reached maximal values around 10 ?
Negative_regulation (reached) of Gene_expression (levels) of HNE in liver associated with stress and injury
8) Confidence 0.05 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.05 Pain Relevance 0.21
-tocopherol to rats undergoing this protocol resulted not only in a reduction of oxidative stress, lipid peroxidation and HNE, but also in decreased synthesis of both collagen type I and TGF ?
Negative_regulation (decreased) of Gene_expression (synthesis) of HNE associated with stress
9) Confidence 0.05 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.58 Pain Relevance 0.15
-tocopherol to rats undergoing this protocol resulted not only in a reduction of oxidative stress, lipid peroxidation and HNE, but also in decreased synthesis of both collagen type I and TGF ?
Negative_regulation (reduction) of Gene_expression (synthesis) of HNE associated with stress
10) Confidence 0.05 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.59 Pain Relevance 0.15
The first published study in 1993 [300] was on human HSC/MFs exposed to very low levels of HNE (1 ?
Negative_regulation (levels) of Gene_expression (exposed) of HNE
11) Confidence 0.05 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.37 Pain Relevance 0
Pretreatment with beraprost attenuated AGML and downregulated the expression of HNE and HO-1, while sensory denervation aggravated AGML and upregulated the expression of HNE and HO-1.
Negative_regulation (downregulated) of Gene_expression (expression) of HNE
12) Confidence 0.04 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 18617559 Disease Relevance 0.18 Pain Relevance 0.08

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