INT36256

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Context Info
Confidence 0.62
First Reported 1987
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 9
Total Number 11
Disease Relevance 4.99
Pain Relevance 5.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ada) extracellular space (Ada) aging (Ada)
cell adhesion (Ada) plasma membrane (Ada) lysosome (Ada)
Anatomy Link Frequency
spinal cord 1
dorsal horn 1
Ada (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 73 100.00 Very High Very High Very High
Endep 12 100.00 Very High Very High Very High
Paracetamol 5 100.00 Very High Very High Very High
Spinal cord 5 99.76 Very High Very High Very High
agonist 2 99.18 Very High Very High Very High
Fibrositis 11 98.84 Very High Very High Very High
abdominal pain 1 96.04 Very High Very High Very High
Pain 6 95.68 Very High Very High Very High
Dorsal horn 1 94.28 High High
Eae 1 94.20 High High
Disease Link Frequency Relevance Heat
Anxiety Disorder 158 100.00 Very High Very High Very High
Tuberculous Peritonitis 1 99.50 Very High Very High Very High
Obesity 5 99.04 Very High Very High Very High
Sleep Disorders 8 98.84 Very High Very High Very High
Pressure And Volume Under Development 5 97.72 Very High Very High Very High
Abdominal Pain 1 96.04 Very High Very High Very High
Pain 4 95.68 Very High Very High Very High
Enteropathy 1 94.52 High High
Glioma 1 94.36 High High
Death 4 91.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, it is concluded that some drugs that inhibit adenosine uptake also modulate adenosine deaminase activity.
Regulation (modulate) of adenosine deaminase associated with adenocard
1) Confidence 0.62 Published 1988 Journal J. Neurosci. Res. Section Abstract Doc Link 3367398 Disease Relevance 0.17 Pain Relevance 0.34
In enzyme assays, amitriptyline had no effect on adenosine kinase or adenosine deaminase activity.
Neg (no) Regulation (effect) of adenosine deaminase associated with adenocard and endep
2) Confidence 0.44 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16156010 Disease Relevance 0.09 Pain Relevance 1.26
Kinetic and thermodynamic studies have been made on the effect of acetaminophen on the activity and structure of adenosine deaminase in 50 mM sodium phosphate buffer pH 7.5, at two temperatures of 27 and 37 degrees C using UV spectrophotometry, circular dichroism (CD) and fluorescence spectroscopy.
Regulation (effect) of adenosine deaminase associated with adenocard and paracetamol
3) Confidence 0.43 Published 2004 Journal J Enzyme Inhib Med Chem Section Abstract Doc Link 15202496 Disease Relevance 0 Pain Relevance 0.44
The effects of the adenosine kinase inhibitors, 5'-amino-5'-deoxyadenosine (NH2dAD) and iodotubercidin (IOT), and the adenosine deaminase inhibitor, 2'-deoxycoformycin (DCF), on adenosine release in a spinal cord superfusion model were studied.
Regulation (effects) of adenosine deaminase in spinal cord associated with adenocard and spinal cord
4) Confidence 0.35 Published 1995 Journal Brain Res. Section Abstract Doc Link 8616636 Disease Relevance 0.09 Pain Relevance 0.93
The further model of AA influencing directly ADA was also tested (i.e. path AA ?
Regulation (influencing) of ADA associated with anxiety disorder
5) Confidence 0.32 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2289811 Disease Relevance 2.13 Pain Relevance 0
This correlated with a selective reduction in mGluR1, but not mGluR5, immunoreactivity in the superficial dorsal horn compared with untreated control rats, in parallel with a significant reduction in the proportion of neurons activated by the mGluR group I agonist 3, 5-dihydroxyphenylglycine (DHPG), whereas the proportion of cells excited by the mGluR5 agonist, trans-azetidine-2,4-dicarboxylic acid (t-ADA) remained unaffected.
Neg (unaffected) Regulation (unaffected) of t-ADA in dorsal horn associated with agonist and dorsal horn
6) Confidence 0.32 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9822771 Disease Relevance 0.14 Pain Relevance 0.66
This study examined the ability of an adenosine kinase inhibitor (5'-amino-5'-deoxyadenosine; NH2dAD), an adenosine deaminase inhibitor (2'-deoxycoformycin), and combinations of these agents to produce a peripheral modulation of the pain signal in the low concentration formalin model.
Spec (examined) Regulation (ability) of adenosine deaminase associated with pain, adenocard and eae
7) Confidence 0.20 Published 1998 Journal Pain Section Abstract Doc Link 9514563 Disease Relevance 0.10 Pain Relevance 0.45
The effect of amitriptyline (A, 20 mg daily) and sertraline (S, 100 mg daily) treatment on patients' superoxide dismutase (SOD), xanthine oxidase (XO), adenosine deaminase (ADA) enzyme activities, thiobarbituric acid reactive substances (TBARS) and NO levels was investigated.
Spec (investigated) Regulation (effect) of adenosine deaminase associated with adenocard and endep
8) Confidence 0.08 Published 2006 Journal Rheumatol. Int. Section Abstract Doc Link 16283318 Disease Relevance 0.68 Pain Relevance 0.44
[A case of a young woman with tuberculous peritonitis diagnosed owing to high value of ADA].
Regulation (value) of ADA associated with tuberculous peritonitis
9) Confidence 0.04 Published 2004 Journal Kansensh?gaku Zasshi Section Title Doc Link 15560383 Disease Relevance 0.80 Pain Relevance 0.10
Influence of adenosine deaminase.
Regulation (Influence) of adenosine deaminase associated with adenocard
10) Confidence 0.01 Published 1987 Journal Int J Obes Section Title Doc Link 3301711 Disease Relevance 0.59 Pain Relevance 0.22
However, cladribine is resistant to the effects of adenosine deaminase.
Regulation (effects) of adenosine deaminase associated with adenocard
11) Confidence 0.01 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2951744 Disease Relevance 0.21 Pain Relevance 0.23

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