INT36262

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Context Info
Confidence 0.49
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 35
Total Number 38
Disease Relevance 28.79
Pain Relevance 14.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Tbce) protein folding (Tbce) cytoskeleton (Tbce)
cytoplasm (Tbce)
Anatomy Link Frequency
PMN 5
lung 3
plasma 1
liver 1
vascular endothelium 1
Tbce (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 10 100.00 Very High Very High Very High
Inflammation 1383 99.92 Very High Very High Very High
agonist 153 99.92 Very High Very High Very High
metalloproteinase 153 99.80 Very High Very High Very High
lidocaine 1024 99.68 Very High Very High Very High
adenocard 446 99.52 Very High Very High Very High
cytokine 398 99.28 Very High Very High Very High
chemokine 190 98.86 Very High Very High Very High
cva 11 98.84 Very High Very High Very High
ischemia 76 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1428 100.00 Very High Very High Very High
Hypoxia 10 100.00 Very High Very High Very High
Apoptosis 216 99.96 Very High Very High Very High
Critical Illness 8 99.84 Very High Very High Very High
Adult Respiratory Distress Syndrome 646 99.68 Very High Very High Very High
Endotoxemia 3 99.66 Very High Very High Very High
Infection 69 99.48 Very High Very High Very High
Cramps 110 99.40 Very High Very High Very High
Peripheral Arterial Disease 3 99.28 Very High Very High Very High
Myocardial Infarction 20 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activated PMNs produce MIP-2 (mouse) or IL-8 (human), which produces an auto-amplification loop of PMN recruitment and activation at the inflamed sites, and this positive feedback is considered to be one of the potential mechanisms by which MIP-2 could amplify the local inflammatory response of the PMNs [23,24].
Positive_regulation (Activated) of PMN associated with inflammatory response
1) Confidence 0.49 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2707360 Disease Relevance 0.91 Pain Relevance 0.30
We investigated whether increased PMN activity in the peripheral blood is a marker for high-grade coronary artery stenosis in patients with angina pectoris.
Spec (whether) Positive_regulation (increased) of PMN in coronary artery associated with coronary stenosis and angina
2) Confidence 0.37 Published 2001 Journal Atherosclerosis Section Abstract Doc Link 11583729 Disease Relevance 0.46 Pain Relevance 0.27
These data indicate that PMN activity in the peripheral blood is increased with the presence of a flow-limiting coronary lesion showing an angiographic filling delay.
Positive_regulation (increased) of PMN in blood
3) Confidence 0.37 Published 2001 Journal Atherosclerosis Section Abstract Doc Link 11583729 Disease Relevance 0.34 Pain Relevance 0.29
Thus, a single dose of endotoxin produced a subjective febrile illness and precipitated sustained PMN activation as indicated by increased PMN cell surface complement receptor number in the absence of C activation.
Positive_regulation (increased) of PMN in PMN associated with fever
4) Confidence 0.08 Published 1987 Journal Surgery Section Abstract Doc Link 3303397 Disease Relevance 0.20 Pain Relevance 0.05
In conclusion, prostaglandin E1 reduces PMN activation in patients with peripheral arterial occlusive disease.
Positive_regulation (activation) of PMN in PMN associated with peripheral arterial disease
5) Confidence 0.08 Published 1998 Journal Vasc Med Section Abstract Doc Link 9892509 Disease Relevance 0.57 Pain Relevance 0.20
In rabbits, mechanical ventilation during endotoxemia synergistically increases alveolar polymorphonuclear cell (PMN) recruitment and cytokine expression in BALF beyond that seen with either endotoxin or mechanical ventilation alone [7,8].
Positive_regulation (increases) of PMN associated with endotoxemia and cytokine
6) Confidence 0.07 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC3002319 Disease Relevance 1.22 Pain Relevance 0.16
Indeed, whereas no changes of CD11b and CD62L expression could be measured in circulating PMN, a lower degree of expression was measured in circulating F4/80+ cells selectively after I/R.
Positive_regulation (circulating) of PMN in F4/80
7) Confidence 0.07 Published 2008 Journal FASEB J Section Body Doc Link PMC2700033 Disease Relevance 0.60 Pain Relevance 0.29
Thus, it is likely that S100A8/A9 complexes reflect, at least in part, the increases in PMN obtained in mice challenged with lidocaine and zymosan at 4 hours, compared to mice received zymosan alone.
Positive_regulation (increases) of PMN associated with lidocaine
8) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.37 Pain Relevance 0.67
The increase in exudate PMN was ?
Positive_regulation (increase) of PMN
9) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.34 Pain Relevance 0.66
In addition, abciximab significantly reduced PMN accumulation in the ischemic myocardium from 38 +/- 1 PMNs/mm2 in untreated hearts to 7 +/- 1 in rats given abciximab.
Positive_regulation (accumulation) of PMN in hearts
10) Confidence 0.06 Published 1999 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 10599051 Disease Relevance 0.55 Pain Relevance 0.13
Although the intratracheal instillation of both LPS and HCl recruited PMN into the lung, the immuno-histochemical expression of NEP in the injured lungs showed less intense staining of the PMN than of the alveolar walls (Figure 4C &4D).
Positive_regulation (recruited) of PMN in lungs
11) Confidence 0.05 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.30 Pain Relevance 0.04
Both complement (C) and neutrophils (PMN) are activated in critically ill patients.
Positive_regulation (activated) of PMN in PMN associated with critical illness
12) Confidence 0.05 Published 1987 Journal Surgery Section Abstract Doc Link 3303397 Disease Relevance 0.32 Pain Relevance 0.07
Thus, the NEP expression was most likely down-regulated on the PMN that were recruited and activated during ALI/ARDS.
Positive_regulation (activated) of PMN associated with adult respiratory distress syndrome
13) Confidence 0.05 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 1.21 Pain Relevance 0.13
In addition, the NEP activity was higher in the LPS-treated mice, in which the recruitment of PMN into the air-space was increased.
Positive_regulation (increased) of PMN
14) Confidence 0.05 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.93 Pain Relevance 0.16
Cyclin-dependent kinase and specific ERK1/2 inhibitors, in comparison, also promote resolution of inflammation by enhancing PMN apoptosis [37], [38].
Positive_regulation (enhancing) of PMN associated with inflammation and apoptosis
15) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 1.34 Pain Relevance 0.70
Even doses as low as 0.008% (w/v) lidocaine, when given together with zymosan, led to a significant increase in the accumulation of PMN at 24 h (?
Positive_regulation (accumulation) of PMN associated with lidocaine
16) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.20 Pain Relevance 0.67
As a result, in the presence of lidocaine, the number of PMN in the exudate was significantly increased at this time point (?
Positive_regulation (increased) of PMN associated with lidocaine
17) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.24 Pain Relevance 0.77
Thus, changes in the balance between pro- and anti-inflammatory cytokines, rather than individual chemokines or specific cytokines, appear to contribute to the observed increases in PMN numbers obtained at 24 h with lidocaine.
Positive_regulation (increases) of PMN associated with chemokine, inflammation, lidocaine and cytokine
18) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 1.44 Pain Relevance 1.11
Therefore, decreases in Galectin-1 levels from lidocaine-treated mice during resolution (i.e. 24 h) might also contribute to delayed PMN clearance, resulting in increased PMN dwell times in exudates (Fig. 1A).


Positive_regulation (increased) of PMN associated with lidocaine
19) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 0.47 Pain Relevance 0.90
In burn wounds, lidocaine increases leukocyte numbers, which suggests an increase in PMN infiltration and/or increased viability of the leukocytes at the burn site [36].
Positive_regulation (increase) of PMN in leukocytes associated with burns, injury and lidocaine
20) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2268966 Disease Relevance 1.23 Pain Relevance 0.96

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