INT36263

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1985
Last Reported 2011
Negated 6
Speculated 1
Reported most in Abstract
Documents 53
Total Number 54
Disease Relevance 34.88
Pain Relevance 12.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CEL) extracellular space (CEL) small molecule metabolic process (CEL)
extracellular region (CEL) lipid metabolic process (CEL) cytoplasm (CEL)
Anatomy Link Frequency
mast cell 7
plasma 3
skin 3
T cell 3
dendrites 2
CEL (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 268 100.00 Very High Very High Very High
metalloproteinase 71 100.00 Very High Very High Very High
Bile 9 100.00 Very High Very High Very High
qutenza 2 100.00 Very High Very High Very High
Glutamate 116 99.98 Very High Very High Very High
rheumatoid arthritis 29 99.76 Very High Very High Very High
adenocard 13 99.64 Very High Very High Very High
Paracetamol 14 99.36 Very High Very High Very High
Buprenorphine 8 99.24 Very High Very High Very High
Analgesic 3 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 20 100.00 Very High Very High Very High
Familial Amyloidotic Polyneuropathy 6 100.00 Very High Very High Very High
Death 135 99.96 Very High Very High Very High
Glioma 47 99.80 Very High Very High Very High
Rheumatoid Arthritis 29 99.76 Very High Very High Very High
Asthma 26 99.64 Very High Very High Very High
Urticaria 13 99.64 Very High Very High Very High
Apoptosis 279 99.54 Very High Very High Very High
Adult Respiratory Distress Syndrome 75 99.42 Very High Very High Very High
Toxicity 17 99.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other studies, however, did not support a role for CEase in transport of unesterified cholesterol to enterocytes; uptake of cholesterol by Caco-2 cells has been reported to be independent of added CEase or of transfection with CEase cDNA [24,25].
Neg (independent) Positive_regulation (independent) of CEase in Caco-2
1) Confidence 0.69 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406500 Disease Relevance 0.20 Pain Relevance 0.03
Depression, psychological stress, tissue injuries, malignancies, carcinogenesis, chronic fatigue syndrome, and experimental allergic encephalomyelitis could be induced at very low physiological concentrations by mycotoxin-induced NKC activity.
Positive_regulation (induced) of NKC in NKC associated with stress, chronic fatigue syndrome, depression, injury and experimental autoimmune encephalomyelitis
2) Confidence 0.67 Published 2003 Journal ScientificWorldJournal Section Abstract Doc Link 14625399 Disease Relevance 1.46 Pain Relevance 0.27
In fact, immune complexes fixing C1q bind to endothelial receptors, thus triggering an upregulation of adhesion molecules, such as E-selectin and intercellular and vascular cell adhesion molecules 1, on the endothelium surface.
Positive_regulation (upregulation) of cell in endothelium associated with adhesions
3) Confidence 0.67 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12114307 Disease Relevance 1.46 Pain Relevance 0.41
Adenosine and inosine both activate mast cell A(3) receptors, liberating vasoactive substances and increasing vascular permeability.
Positive_regulation (activate) of cell in mast cell associated with adenocard
4) Confidence 0.67 Published 2002 Journal Toxicon Section Abstract Doc Link 11738231 Disease Relevance 0.35 Pain Relevance 0.21
There was a significant difference in the incidence of positive intradermal tests, radioimmunoassay tests and evidence of an IgE-mediated reaction in patients whose mast cell tryptase concentrations were increased.
Positive_regulation (increased) of cell in mast cell
5) Confidence 0.67 Published 1998 Journal Br J Anaesth Section Abstract Doc Link 9505773 Disease Relevance 0.21 Pain Relevance 0
Seven of 143 patients whose mast cell tryptase concentrations were not increased at appropriate sampling times had positive tests for IgE antibodies, and in 33 of 158 patients with increased mast cell tryptase concentrations no IgE antibodies were detected.
Neg (not) Positive_regulation (increased) of cell in mast cell
6) Confidence 0.67 Published 1998 Journal Br J Anaesth Section Abstract Doc Link 9505773 Disease Relevance 0.21 Pain Relevance 0
Human peripheral blood T lymphocyte proliferation after activation of the T cell receptor: effects of unsaturated fatty acids.
Positive_regulation (activation) of cell in T cell
7) Confidence 0.67 Published 1999 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Title Doc Link 10471124 Disease Relevance 0.56 Pain Relevance 0.19
Molecular changes in the distal stump include upregulation of neurotrophins, neural cell adhesion molecules, cytokines and other soluble factors and their corresponding receptors.
Positive_regulation (upregulation) of cell in neural associated with adhesions and cytokine
8) Confidence 0.49 Published 1999 Journal Brain Pathol. Section Abstract Doc Link 10219748 Disease Relevance 0.68 Pain Relevance 0.13
This assay has revealed that plasma calcitonin levels in normal rats are much lower than the detection limits of most existing assays, but can increase by 100-fold on activation of the C-cell Ca2+ receptor.
Positive_regulation (activation) of cell in plasma
9) Confidence 0.49 Published 1998 Journal Endocrine Section Abstract Doc Link 10221596 Disease Relevance 0.22 Pain Relevance 0.04
Cell-surface NAD(P)H-oxidase: relationship to trans-plasma membrane NADH-oxidoreductase and a potential source of circulating NADH-oxidase.
Positive_regulation (source) of Cell in plasma associated with qutenza
10) Confidence 0.49 Published 2000 Journal Antioxid. Redox Signal. Section Title Doc Link 11229532 Disease Relevance 0 Pain Relevance 0.10
Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH(2)-terminal protein kinase-related cell death pathway.
Positive_regulation (activating) of cell associated with paracetamol, apoptosis, death and glioma
11) Confidence 0.49 Published 2001 Journal Mol. Pharmacol. Section Title Doc Link 11562448 Disease Relevance 0.81 Pain Relevance 0.94
Total cell counts were elevated postsurgery in smokers and subjects claiming childhood but not current asthma, who also showed increased postsurgical BAL IL-1 but not increased TNFalpha.
Neg (not) Positive_regulation (increased) of BAL associated with asthma and nicotine addiction
12) Confidence 0.49 Published 2008 Journal Lung Section Abstract Doc Link 18066622 Disease Relevance 0.20 Pain Relevance 0.08
These findings suggest that disrupted plaques and intraluminal thrombus, angiographically visible as complex lesions are associated with increased concentrations of T helper 1 cell related interleukins, mainly IL-18, and IL-18 being a possible bio-marker for risk stratification in UA.
Spec (possible) Positive_regulation (increased) of cell in plaques associated with angina and thrombosis
13) Confidence 0.49 Published 2005 Journal Cytokine Section Abstract Doc Link 15927856 Disease Relevance 0.67 Pain Relevance 0.44
Repeated daily press needle stimulation of True ST. 36 increased NC telomere 450-700 ng BDORT units.
Positive_regulation (increased) of NC in telomere
14) Confidence 0.49 Published 2009 Journal Acupunct Electrother Res Section Abstract Doc Link 20344885 Disease Relevance 1.46 Pain Relevance 0.80
Both enhanced and reduced NK activity have been reported in different in vivo and in vitro studies.
Positive_regulation (enhanced) of NK
15) Confidence 0.49 Published 1994 Journal Isr. J. Med. Sci. Section Abstract Doc Link 8088979 Disease Relevance 0 Pain Relevance 0.66
In order to evaluate the function of the autonomic nervous system, power spectral analysis of heart rate fluctuation and waveform observation of cutaneous vasomotion were conducted in 3 patients with familial amyloid polyneuropathy Type 1 (FAP) (Met30) with autonomic disorders.
Positive_regulation (conducted) of FAP in autonomic nervous system associated with autonomic nervous system disease and familial amyloidotic polyneuropathy
16) Confidence 0.49 Published 1996 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 8884698 Disease Relevance 0.62 Pain Relevance 0.06
Their presence favours an IgE-mediated cause but does not always distinguish between anaphylactoid and anaphylactoid reactions, and patients in whom mast cell tryptase concentrations are not increased still require skin testing.
Neg (not) Positive_regulation (increased) of cell in skin
17) Confidence 0.49 Published 1998 Journal Br J Anaesth Section Abstract Doc Link 9505773 Disease Relevance 0.09 Pain Relevance 0
CONCLUSION: Quantitative assessment of T cell beta2-integrin activation allows to identify high risk patients with UA and sC without established MI; furthermore, it is associated with incidence of future cardiovascular events independent of conventional risk factors (troponin, hsCRP).


Positive_regulation (activation) of cell in T cell
18) Confidence 0.45 Published 2009 Journal Basic Res. Cardiol. Section Body Doc Link 19139946 Disease Relevance 0.18 Pain Relevance 0
Nonimmunological urticarias result from mast cell activation through membrane receptors involved in innate immunity (e.g., complement, Toll-like, cytokine/chemokine, opioid) or by direct toxicity of xenobiotics (haptens, drugs).
Positive_regulation (activation) of cell in mast cell associated with urticaria, chemokine, toxicity, opioid and cytokine
19) Confidence 0.45 Published 2006 Journal Clin Rev Allergy Immunol Section Abstract Doc Link 16461989 Disease Relevance 1.31 Pain Relevance 0.19
FLZ that is widely abused and enlarges BPN toxicity appeared the most potent to increase mu-cell surface receptor density at the lowest dose of 0.2 mg/kg.
Positive_regulation (increase) of cell associated with toxicity and buprenorphine
20) Confidence 0.45 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19443999 Disease Relevance 0.10 Pain Relevance 1.39

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox