INT36267

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Context Info
Confidence 0.69
First Reported 1987
Last Reported 2010
Negated 1
Speculated 4
Reported most in Abstract
Documents 29
Total Number 33
Disease Relevance 11.09
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CYP1A1) mitochondrion (CYP1A1) small molecule metabolic process (CYP1A1)
oxidoreductase activity (CYP1A1) endoplasmic reticulum (CYP1A1) enzyme binding (CYP1A1)
Anatomy Link Frequency
lung 5
body 2
hepatocytes 1
fat 1
liver 1
CYP1A1 (Homo sapiens)
CYP1A1 - P4501A (2)
Pain Link Frequency Relevance Heat
alcohol 21 99.98 Very High Very High Very High
antagonist 22 98.08 Very High Very High Very High
aspirin 4 95.68 Very High Very High Very High
Bile 1 92.24 High High
Analgesic 5 91.00 High High
endometriosis 8 84.56 Quite High
pain pelvic 2 79.44 Quite High
Gabapentin 3 78.48 Quite High
carbamazepine 12 77.60 Quite High
Chronic pancreatitis 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 104 99.80 Very High Very High Very High
Nicotine Addiction 462 99.20 Very High Very High Very High
Stress 189 97.16 Very High Very High Very High
Lung Cancer 40 96.96 Very High Very High Very High
Cancer 172 94.24 High High
Disease 54 89.68 High High
Apoptosis 187 89.40 High High
Hepatocellular Cancer 7 89.16 High High
Pulmonary Disease 88 88.28 High High
Toxicity 18 86.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vivo, however, fluparoxan did show some capacity for CYP1A induction.
Positive_regulation (induction) of CYP1A
1) Confidence 0.69 Published 1997 Journal Xenobiotica Section Abstract Doc Link 9058530 Disease Relevance 0 Pain Relevance 0.10
Cytochrome P4501A (CYP1A) induction in rat and man by the benzodioxino derivative, fluparoxan.
Positive_regulation (induction) of CYP1A (P4501A)
2) Confidence 0.69 Published 1997 Journal Xenobiotica Section Title Doc Link 9058530 Disease Relevance 0 Pain Relevance 0.05
At 24 h, TCDD significantly increased CYP1A1 and CYP1B1 mRNA, and at 72 h, TCDD significantly increased EROD activity and CYP1B1 protein compared to explants cultured without TCDD for similar times.
Positive_regulation (increased) of CYP1A1
3) Confidence 0.68 Published 2001 Journal Toxicol. Sci. Section Abstract Doc Link 11452143 Disease Relevance 0.35 Pain Relevance 0.18
In animals, one of the most sensitive effects of physiologically significant body burdens has been the induction of cytochrome P450 1 (CYP1) family of enzymes.
Positive_regulation (induction) of CYP1 in body
4) Confidence 0.67 Published 2006 Journal Environ. Sci. Technol. Section Abstract Doc Link 17051818 Disease Relevance 0 Pain Relevance 0
This study examined the capacity of CYP1 enzyme induction to be a biomarker of exposure to a mixture of PCBs and PCDFs and of adverse human health effects.
Spec (examined) Positive_regulation (induction) of CYP1
5) Confidence 0.67 Published 2006 Journal Environ. Sci. Technol. Section Abstract Doc Link 17051818 Disease Relevance 0 Pain Relevance 0
Regulation of other genes, eg. induction of CYP1A1, IFNGR1 and WARS and downregulation of ER?
Positive_regulation (induction) of CYP1A1
6) Confidence 0.64 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.64 Pain Relevance 0
As described, we also observed significantly stronger induction of CYP1A1 transcripts than CYP1B1 with black cohosh treatment.
Positive_regulation (induction) of CYP1A1
7) Confidence 0.64 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.06 Pain Relevance 0
There are genetic polymorphisms in the inducibility of CYP1A1, with some evidence that high inducibility is more common in patients with lung cancer.
Positive_regulation (inducibility) of CYP1A1 in lung associated with lung cancer
8) Confidence 0.61 Published 1999 Journal Clin Pharmacokinet Section Abstract Doc Link 10427467 Disease Relevance 0.64 Pain Relevance 0
In animals, one of the most sensitive effects of physiologically significant body burdens has been the induction of cytochrome P450 1 (CYP1) family of enzymes.
Positive_regulation (induction) of cytochrome P450 1 in body
9) Confidence 0.58 Published 2006 Journal Environ. Sci. Technol. Section Abstract Doc Link 17051818 Disease Relevance 0 Pain Relevance 0
As judged by immunochemical quantitation, P-450ALC is also induced in the animals by other diverse agents, including imidazole, trichloroethylene, acetone, pyrazole, and isoniazid.
Positive_regulation (induced) of P-450ALC
10) Confidence 0.50 Published 1987 Journal Arch. Toxicol. Section Abstract Doc Link 3304205 Disease Relevance 0.06 Pain Relevance 0.25
Alcohol-inducible cytochrome P-450 (P-450ALC).
Positive_regulation (inducible) of P-450ALC associated with alcohol
11) Confidence 0.50 Published 1987 Journal Arch. Toxicol. Section Title Doc Link 3304205 Disease Relevance 0.07 Pain Relevance 0.28
Of the family of P-450 cytochromes occurring in rabbit liver microsomes, only isozyme 3a (P-450ALC) is induced by alcohol administration and is effective in catalyzing the reaction: ethanol +02+NADPH+H+----acetaldehyde +2H2O+NADP+.
Positive_regulation (induced) of P-450ALC in liver associated with alcohol
12) Confidence 0.50 Published 1987 Journal Arch. Toxicol. Section Abstract Doc Link 3304205 Disease Relevance 0 Pain Relevance 0.20
The simultaneous induction of CYP1A1 and CYP1B1 in both types of lung cells obtained from BAL and pulmonary epithelial cells after smoking cigarettes, as found in the present study, may therefore enhance an individual susceptibility for chemically induced lung cancer.
Positive_regulation (induction) of CYP1A1 in lung associated with lung cancer and nicotine addiction
13) Confidence 0.50 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.70 Pain Relevance 0
The observed induction of CYP1A1 and CYP2S1 in bronchoalveolar macrophages and bronchial biopsies of smokers is of importance because of their contribution to the metabolic activation of tobacco smoke components, namely polycyclic aromatic hydrocarbons, which can lead to the development of lung cancer (Georgiadis et al. 2005).
Positive_regulation (induction) of CYP1A1 in lung associated with lung cancer and nicotine addiction
14) Confidence 0.50 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.77 Pain Relevance 0
Thus, the strong induction of CYP1A1 and CYP1B1 can be explained, at least in part, in terms of AHR-mediated transcriptional activation.
Positive_regulation (induction) of CYP1A1
15) Confidence 0.50 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.31 Pain Relevance 0
Our findings of a simultaneous induction of CYP1A1 and CYP1B1 in different lung compartments after exposure to tobacco smoke demonstrate up-regulation of the pulmonary enzyme system and agree well with other reports (McLemore et al. 1990).
Positive_regulation (induction) of CYP1A1 in lung associated with nicotine addiction
16) Confidence 0.50 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.46 Pain Relevance 0
SAL inhibited the increase in CYP1A1, -1A2, and -1B1 mRNA levels that occurs on exposure to TCDD.
Positive_regulation (increase) of CYP1A1 in 1A2
17) Confidence 0.49 Published 2004 Journal Cancer Res. Section Abstract Doc Link 14729655 Disease Relevance 0.16 Pain Relevance 0.27
Fluparoxan is an alpha 2-adrenoceptor antagonist that has a relatively planar, tricyclic structure and was considered a potential substrate and inducer of cytochrome P4501A (CYP1A) enzymes. 2.
Positive_regulation (inducer) of CYP1A (P4501A) associated with antagonist
18) Confidence 0.46 Published 1997 Journal Xenobiotica Section Abstract Doc Link 9058530 Disease Relevance 0 Pain Relevance 0.05
Accordingly, pancreatic and biliary secretions were studied in Syrian golden hamsters that were reared for 6 mo on low or high (16% corn oil) fat diets that were supplemented with a prototype inducer of CYP2 (200 ppm phenobarbitone) or CYP1 (100 ppm beta naphthoflavone) enzyme families, with or without a putative enzyme inhibitor (400 ppm cimetidine).
Positive_regulation (inducer) of CYP1 in fat
19) Confidence 0.45 Published 1995 Journal Int. J. Pancreatol. Section Abstract Doc Link 8530827 Disease Relevance 0.45 Pain Relevance 0.26
Polycyclic aromatic hydrocarbons in tobacco smoke are believed to be responsible for the induction of cytochrome P450 (CYP) 1A1, CYP1A2 and possibly CYP2E1, CYP1A1 is primarily an extrahepatic enzyme found in lung and placenta.
Spec (possibly) Positive_regulation (induction) of CYP1A1 in placenta associated with nicotine addiction
20) Confidence 0.44 Published 1999 Journal Clin Pharmacokinet Section Abstract Doc Link 10427467 Disease Relevance 0.59 Pain Relevance 0

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