INT36287

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Context Info
Confidence 0.47
First Reported 1987
Last Reported 2010
Negated 5
Speculated 2
Reported most in Body
Documents 96
Total Number 98
Disease Relevance 58.93
Pain Relevance 11.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD4) cell adhesion (CD4) plasma membrane (CD4)
enzyme binding (CD4)
Anatomy Link Frequency
T cells 20
lymphocytes 8
plasma 3
B cells 3
macrophages 2
CD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 426 100.00 Very High Very High Very High
alcohol 150 100.00 Very High Very High Very High
psoriasis 49 99.92 Very High Very High Very High
addiction 602 99.80 Very High Very High Very High
chemokine 170 99.64 Very High Very High Very High
tolerance 34 99.44 Very High Very High Very High
spinal inflammation 250 99.12 Very High Very High Very High
Acupuncture 280 97.84 Very High Very High Very High
cytokine 439 97.76 Very High Very High Very High
Inflammation 294 97.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 435 100.00 Very High Very High Very High
Apoptosis 155 100.00 Very High Very High Very High
Lymphopenia 31 100.00 Very High Very High Very High
Shock 10 100.00 Very High Very High Very High
Cryptococcus Infection 12 99.98 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2966 99.92 Very High Very High Very High
Disease 546 99.92 Very High Very High Very High
Psoriasis 60 99.92 Very High Very High Very High
Autoimmune Disease 36 99.90 Very High Very High Very High
Non-genital Cutaneous Warts 7 99.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we demonstrate that it rapidly binds CD4+ cells in vivo.
CD4 Binding (binds) of
1) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929209 Disease Relevance 0.27 Pain Relevance 0
Blocking the gp120 interaction with CD4 by a small molecule BMS-378806 protected most macaques from vaginal SHIV challenge, verifying that the CD4-envelope interaction is a possible target for a microbicide [25].
CD4 Binding (interaction) of
2) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929209 Disease Relevance 0.29 Pain Relevance 0
To infect target cells, the human immunodeficiency virus (HIV) type I (HIV-1) must engage not only the well-known CD4 molecule, but it also requires one of several recently described coreceptors.
CD4 Binding (engage) of associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.41 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10820198 Disease Relevance 0.90 Pain Relevance 0.11
Alternatively, effector T-cells of the Th1 subset activates macrophages by CD154 – CD4+0 interactions and by secreting IFN-?.
CD4 Binding (interactions) of in effector T-cells
4) Confidence 0.40 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 0.67 Pain Relevance 0.29
To our knowledge, this is the first case of pleural cryptococcosis associated with idiopathic CD4 positive T lymphocytopenia.
CD4 Binding (associated) of associated with lymphopenia and cryptococcus infection
5) Confidence 0.37 Published 2004 Journal Intern. Med. Section Abstract Doc Link 15575251 Disease Relevance 0.78 Pain Relevance 0.08
While an argument in favour of a lower CD4 threshold could be that these individuals would be eligible for ART once their CD4 count has descended to below 200 cells/?
CD4 Binding (count) of
6) Confidence 0.37 Published 2010 Journal BMC Int Health Hum Rights Section Body Doc Link PMC2864209 Disease Relevance 0.43 Pain Relevance 0
L and those with CD4 >350 cells/?
CD4 Binding (those) of
7) Confidence 0.37 Published 2010 Journal BMC Int Health Hum Rights Section Body Doc Link PMC2864209 Disease Relevance 0.96 Pain Relevance 0
L, recent studies have raised concern about the risk of death from liver, renal, and heart diseases, as well as from "non-AIDS" cancers; incidence of these diseases is increased at lower CD4 counts, with significant differences seen between those with CD4 <350 cells/?
CD4 Binding (those) of in heart associated with cancer, heart disease, acquired immune deficiency syndrome or hiv infection, disease and death
8) Confidence 0.37 Published 2010 Journal BMC Int Health Hum Rights Section Body Doc Link PMC2864209 Disease Relevance 0.98 Pain Relevance 0
Recurrent 'sterile' verrucous cyst abscesses and epidermodysplasia verruciformis-like eruption associated with idiopathic CD4 lymphopenia.
CD4 Binding (associated) of associated with non-genital cutaneous warts, lymphopenia, cyst and abscess
9) Confidence 0.37 Published 2003 Journal Br. J. Dermatol. Section Title Doc Link 14511000 Disease Relevance 1.97 Pain Relevance 0.09
Baseline TLC, DLC, ESR, platelet count, hemoglobin and CD4 count were done.
CD4 Binding (count) of in platelet
10) Confidence 0.37 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792597 Disease Relevance 0.83 Pain Relevance 0
Unbound CD4-specific DARPin 57.2 was detectable in the plasma of macaques within 30 minutes after injection (Figure 2).
CD4 Binding (Unbound) of in plasma
11) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929209 Disease Relevance 0 Pain Relevance 0
DARPin-bound CD4+ cells were detected in the peripheral blood as early as 30 minutes after the injection, decreasing within 6 hours and being almost undetectable within 24 hours.
CD4 Binding (bound) of in blood
12) Confidence 0.36 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2929209 Disease Relevance 0.17 Pain Relevance 0
Graded antigen stability occurred: CD3 most stable, CD8 least, and CD4 intermediate.
CD4 Binding (intermediate) of
13) Confidence 0.36 Published 1987 Journal J. Histochem. Cytochem. Section Abstract Doc Link 3309048 Disease Relevance 0 Pain Relevance 0.06
There was no association between heavy alcohol consumption and CD4 cell count among those on ART, in analyses that adjusted for baseline CD4, adherence to ART, homelessness, depressive symptoms, and several other variables.
CD4 Neg (no) Spec (analyses) Binding (association) of associated with depression and alcohol
14) Confidence 0.36 Published 2010 Journal Curr HIV/AIDS Rep Section Body Doc Link PMC2938419 Disease Relevance 0.54 Pain Relevance 0.35
Identification of potent macaque CD4-binding DARPins
CD4 Binding (binding) of
15) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929209 Disease Relevance 0.18 Pain Relevance 0
There are few CD4+ cells in the vaginal mucosal tissue, which makes it difficult to reliably quantify the kinetics and the effectiveness of CD4-specific DARPin binding after it is applied topically.
CD4 Binding (binding) of
16) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929209 Disease Relevance 0.31 Pain Relevance 0
More extensive analysis using blood revealed that DARPin 57.2 bound to all CD4+ cell types (T cells, monocytes, dendritic cells) in vivo and in vitro with the amount of binding directly proportional to the amount of CD4 on the cell surface.
CD4 Binding (binding) of in blood
17) Confidence 0.35 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2929209 Disease Relevance 0.13 Pain Relevance 0
Analysis of these acute time points revealed that CD4+ cells in the lymph nodes were already bound by DARPin 57.2 30 minutes after the injection (Figure 4D).
CD4 Binding (bound) of in lymph nodes
18) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929209 Disease Relevance 0 Pain Relevance 0
We have previously characterized a panel of CD4-specific DARPins, which efficiently inhibit infection by a broad range of HIV strains and provided preliminary evidence that human CD4-specific DARPins bound macaque CD4 and inhibited SIV replication in vitro, without affecting the CD4+ memory T cell function [8].
CD4 Binding (bound) of in memory T cell associated with acquired immune deficiency syndrome or hiv infection, sprains and strains and infection
19) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929209 Disease Relevance 0.62 Pain Relevance 0
We previously described the identification of human CD4-specific DARPins that specifically bound to human and macaque CD4 and inhibited HIV and SIV infection in vitro [8].
CD4 Binding (bound) of associated with acquired immune deficiency syndrome or hiv infection and infection
20) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929209 Disease Relevance 0.27 Pain Relevance 0

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