INT36293

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Context Info
Confidence 0.25
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 14.50
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtor) mitochondrion (Mtor) Golgi apparatus (Mtor)
endoplasmic reticulum (Mtor) nucleus (Mtor) kinase activity (Mtor)
Anatomy Link Frequency
brains 7
neurons 4
pyramidal neurons 1
liver 1
IB4 1
Mtor (Mus musculus)
Pain Link Frequency Relevance Heat
c fibre 4 99.36 Very High Very High Very High
Somatostatin 1 98.92 Very High Very High Very High
Pyramidal cell 108 98.88 Very High Very High Very High
Hippocampus 90 96.36 Very High Very High Very High
qutenza 17 95.32 Very High Very High Very High
nociceptor 1 79.68 Quite High
Analgesic 4 70.88 Quite High
Inflammation 3 64.96 Quite High
anesthesia 21 64.24 Quite High
Spinal cord 3 58.16 Quite High
Disease Link Frequency Relevance Heat
Parkinson's Disease 1062 99.86 Very High Very High Very High
Disease 990 99.84 Very High Very High Very High
Pancreatic Cancer 20 99.52 Very High Very High Very High
Apoptosis 7 98.20 Very High Very High Very High
Targeted Disruption 182 97.96 Very High Very High Very High
Nociception 1 97.56 Very High Very High Very High
Cancer 49 94.68 High High
Aging 36 94.36 High High
Neurodegenerative Disease 162 94.16 High High
Movement Disorders 36 93.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In mammals, the TRPV subfamily is exclusively expressed in small- to medium-sized primary sensory neurons that also co-express some chemical markers (i.e. isolectin B4 (IB4), fluoride-resistant acid phosphatase (FRAP), the P2X3 purinoceptor (a receptor provoked by ATP-induced nociception) and Ret, a glial cell line-derived neurotrophic factor receptor).
Gene_expression (co-express) of FRAP in IB4 associated with nociception
1) Confidence 0.25 Published 2006 Journal Anat Sci Int Section Abstract Doc Link 16955665 Disease Relevance 0.17 Pain Relevance 0.49
These include depletion of the enzyme FRAP and the peptides SP, CCK, somatostatin, CGRP and an increase of VIP.
Gene_expression (depletion) of FRAP associated with somatostatin
2) Confidence 0.25 Published 1987 Journal Acta Physiol Hung Section Abstract Doc Link 3310519 Disease Relevance 0 Pain Relevance 0.66
In the present study, we found that a submicromolar concentration of As2O3 significantly and dose-dependently decreased phosphorylation of Akt protein and its downstream targets, mTOR and p70s6k, during myogenic differentiation.
Gene_expression (targets) of mTOR
3) Confidence 0.10 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920914 Disease Relevance 0.55 Pain Relevance 0.06
Immunohistochemical analysis showed moderate levels of mTor and Atg7 immunostaining in pyramidal neurons in control and AD cases (Figure 2A, B, D, E).
Gene_expression (levels) of mTor in pyramidal neurons associated with pyramidal cell and disease
4) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.91 Pain Relevance 0.08
The increased levels of mTor and reduced Atg7 levels suggest there may be altered activation of the autophagy pathway in the brains of DLB patients.
Gene_expression (levels) of mTor in brains associated with parkinson's disease
5) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.90 Pain Relevance 0.09
The increased levels of mTor and reduced Atg7 levels suggest there may be altered activation of the autophagy pathway in the brains of DLB patients.
Gene_expression (levels) of mTor in brains associated with parkinson's disease
6) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.90 Pain Relevance 0.09
Consistent with the studies in human brains, levels of mTor and p-mTor were increased in the mebrane fractions from brains of ?
Gene_expression (levels) of mTor in brains
7) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.43 Pain Relevance 0.05
Consistent with the studies in human brains, levels of mTor and p-mTor were increased in the mebrane fractions from brains of ?
Gene_expression (levels) of p-mTor in brains
8) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.43 Pain Relevance 0.05
-syn tg mice levels of mTor were elevated and Atg7 expression was reduced. mTor and LC3 was co-localized with neurons displaying ?
Gene_expression (expression) of mTor in neurons
9) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 1.17 Pain Relevance 0
Double-labeling studies showed that mTor and LC3 were abundant in neurons displaying ?
Gene_expression (abundant) of mTor in neurons
10) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.14 Pain Relevance 0.10
Several advances have accompanied the increasing number of indications and these excellent results: (a) the development of more specific immunosuppressive drugs to prevent rejection, the incidence of which is currently less than 20%: tacrolimus, mycophenolic acid, anti-IL2 receptor antibodies, mTOR inhibitors, (b) a policy of active recruitment of organs together with surgical innovations (split liver, domino LT, living donor transplantation) contributing to the expansion of the pool of organs, (c) standardization of organ allocation policies, based on the sickest first policy.
Gene_expression (antibodies) of mTOR in liver
11) Confidence 0.07 Published 2009 Journal Gastroenterol. Clin. Biol. Section Abstract Doc Link 19556084 Disease Relevance 0.36 Pain Relevance 0.06
Compared to non-demented controls and AD cases, levels of mTor and phosphorylated-mTor (p-mTor) were elevated in the brains of DLB cases (Figure 1A, C).
Gene_expression (levels) of mTor in brains associated with parkinson's disease and disease
12) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.76 Pain Relevance 0.03
Compared to non-demented controls and AD cases, levels of mTor and phosphorylated-mTor (p-mTor) were elevated in the brains of DLB cases (Figure 1A, C).
Gene_expression (levels) of mTor in brains associated with parkinson's disease and disease
13) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.77 Pain Relevance 0.03
In the non tg and APP tg mice, immunohistochemical analysis showed moderate levels of mTor and Atg7 immunostaining in pyramidal neurons in the neocortex (Figure 6A, B, D, E, G) and hippocampus (not shown).
Gene_expression (levels) of mTor in hippocampus associated with pyramidal cell and hippocampus
14) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.19 Pain Relevance 0.13
To investigate the effects of postmortem delay and fixation on the levels of mTor immunoreactivity, preliminary studies were performed in a subset of cases (n?
Gene_expression (levels) of mTor
15) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0 Pain Relevance 0
In DLB brains, mTor was more abundant in neurons displaying ?
Gene_expression (abundant) of mTor in neurons associated with parkinson's disease
16) Confidence 0.06 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2824828 Disease Relevance 1.50 Pain Relevance 0
-syn tg mice might be in part related to increased levels of mTor, we investigated whether blocking mTor with rapamycin might promote ?
Gene_expression (levels) of mTor
17) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.19 Pain Relevance 0.03
20,000, Cell Signaling) detected with Tyramide Red, and either mTor, Cathepsin D or LC3 detected with fluorescein isothiocyanate (FITC)-conjugated secondary antibodies (1?
Gene_expression (detected) of mTor
18) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0 Pain Relevance 0
By immunoblot analysis, compared to controls and AD, in DLB cases levels of mTor were elevated and Atg7 were reduced.
Gene_expression (levels) of mTor associated with parkinson's disease and disease
19) Confidence 0.06 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2824828 Disease Relevance 1.45 Pain Relevance 0
-syn tg mice levels of mTor were elevated and Atg7 expression was reduced. mTor and LC3 was co-localized with neurons displaying ?
Gene_expression (expression) of mTor in neurons
20) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 1.13 Pain Relevance 0

General Comments

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