INT36309

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 6.42
Pain Relevance 4.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (DIO2) plasma membrane (DIO2) cellular nitrogen compound metabolic process (DIO2)
Anatomy Link Frequency
striatum 1
DIO2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 364 100.00 Very High Very High Very High
depression 65 100.00 Very High Very High Very High
Enkephalin 17 100.00 Very High Very High Very High
dopamine receptor 44 99.96 Very High Very High Very High
withdrawal 9 99.42 Very High Very High Very High
Glutamate receptor 6 98.56 Very High Very High Very High
midbrain 2 96.20 Very High Very High Very High
agonist 82 95.44 Very High Very High Very High
opioid receptor 17 94.88 High High
mu opioid receptor 4 94.44 High High
Disease Link Frequency Relevance Heat
Depression 74 100.00 Very High Very High Very High
Li-fraumeni Syndrome 153 99.64 Very High Very High Very High
Parkinson's Disease 26 98.76 Very High Very High Very High
Dyskinesias 6 98.24 Very High Very High Very High
Galactorrhea 248 97.20 Very High Very High Very High
Targeted Disruption 6 95.56 Very High Very High Very High
Frailty 5 95.08 Very High Very High Very High
Psychosis 36 94.08 High High
Syndrome 61 93.68 High High
Thyroid Disease 12 91.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clinically, the patients with a decreased number of striatal D-2 receptors were more disabled and had lost the beneficial response to levodopa.
Negative_regulation (decreased) of D-2
1) Confidence 0.57 Published 1984 Journal Acta Physiol Pharmacol Latinoam Section Abstract Doc Link 6099688 Disease Relevance 0.41 Pain Relevance 0.46
Clinically, the patients with a decreased number of striatal D-2 receptors were more disabled and had lost the beneficial response to levodopa.
Negative_regulation (decreased) of D-2
2) Confidence 0.57 Published 1983 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 6308149 Disease Relevance 0.57 Pain Relevance 0.11
PET scans have shown frontal hypometabolism and loss of striatal D-2 dopamine receptors.
Negative_regulation (loss) of D-2 associated with dopamine receptor
3) Confidence 0.42 Published 1987 Journal Can J Neurol Sci Section Abstract Doc Link 3315157 Disease Relevance 1.10 Pain Relevance 0.23
With regard to the behaviour of striatal D-2 receptors it was possible to divide parkinsonian patients into two subgroups, because either an increase or a decrease in the number of D-2 receptors was found.
Negative_regulation (decrease) of D-2 associated with parkinson's disease
4) Confidence 0.41 Published 1983 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 6308149 Disease Relevance 0.50 Pain Relevance 0
In addition, there was also a small independent effect of MHC-d2 on health after controlling for the effect of nonMHC-d2, with individuals with greater MHC-d2 reporting fewer symptoms.
Negative_regulation (effect) of d2
5) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712076 Disease Relevance 0.07 Pain Relevance 0
Unlike the effect of nonMHC-d2, this effect was mainly driven by allelic diversity (d2) at one locus, D6S2883.
Negative_regulation (effect) of d2
6) Confidence 0.32 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712076 Disease Relevance 0.51 Pain Relevance 0
It is well accepted that, in humans, most circulating T3 is derived from extrathyroidal deiodination of T4 via D2 [3]; thus, it makes sense to hypothesize that defects in D2 expression/activity could interfere with the efficacy of L-T4 monotherapy.
Negative_regulation (defects) of D2
7) Confidence 0.17 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2950057 Disease Relevance 0.72 Pain Relevance 0.10
The single nucleotide polymorphism A/G in DIO2 predicts a threonine to alanine substitution at codon 92 (Thr92Ala) and, in subjects homozygous for the Ala allele, D2 velocity was reported to be decreased in an early study [14], but this may have been the result of an artifact [15].
Negative_regulation (decreased) of D2
8) Confidence 0.15 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2950057 Disease Relevance 0.31 Pain Relevance 0
Taken together, these results suggest that the down-regulation of D2 dopamine receptor and D2 receptor messenger RNA is the result of the persistent stimulation of D2 receptors and that the up-regulation of mu opioid receptors may be a compensatory response to a decreased biosynthesis of enkephalin.
Negative_regulation (regulation) of D2 associated with dopamine receptor, mu opioid receptor and enkephalin
9) Confidence 0.14 Published 2008 Journal Theor Biol Med Model Section Body Doc Link PMC2615745 Disease Relevance 0.12 Pain Relevance 0.50
During withdrawal they have shown significant reductions in DA D2 receptors and in DA release in drug abusers.
Negative_regulation (reductions) of D2 associated with dopamine and withdrawal
10) Confidence 0.14 Published 2008 Journal Theor Biol Med Model Section Body Doc Link PMC2615745 Disease Relevance 0.39 Pain Relevance 0.66
High dosages of amisulpride seem to preferentially antagonize postsynaptic D2/D3 receptors, resulting in reduced dopamine transmission, while low dosages preferentially block presynaptic D2/D3 receptors, resulting in enhanced dopamine transmission (McKeage and Plosker 2004).
Negative_regulation (block) of D2 associated with dopamine
11) Confidence 0.11 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.14 Pain Relevance 0.25
Indeed, clinical studies of pharmacokinetics have shown a transient D2 blockade by atypical antipsychotics with an early hyperprolactinemic effect after acute administration.
Negative_regulation (blockade) of D2
12) Confidence 0.10 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.19 Pain Relevance 0.40
After applying t-HFS for 20 minutes discrimination thresholds on the right d2 were reduced.
Negative_regulation (reduced) of d2
13) Confidence 0.08 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2244613 Disease Relevance 0.20 Pain Relevance 0
In contrast to t-HFS, 20 minutes of continuous low-frequency stimulation (t-LFS @ 1 Hz) led to a decline in tactile discrimination performance on the right stimulated d2.
Negative_regulation (decline) of d2 associated with li-fraumeni syndrome
14) Confidence 0.08 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2244613 Disease Relevance 0.46 Pain Relevance 0
After 20 min of t-LFS, discrimination performance of the right d2 was impaired in all subjects as indicated by a significant increase in discrimination thresholds of 0.15 ± 0.04 mm, from 1.57 ± 0.06 mm to 1.72 ± 0.04 mm (rmANOVA with factor SESSION F(1,12) = 10.608; p = 0.007, see Fig. 5).
Negative_regulation (impaired) of d2 associated with li-fraumeni syndrome
15) Confidence 0.08 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2244613 Disease Relevance 0.39 Pain Relevance 0
Extra-cellular dopamine levels are increased in the striatum, causing a depression in mRNA levels of both D1 and D2 receptors and decreased stores of dopamine [71, 96].
Negative_regulation (depression) of D2 in striatum associated with dopamine and depression
16) Confidence 0.04 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2866461 Disease Relevance 0.20 Pain Relevance 0.57
6.0 ű1.1), and closed (d2<4.5 Å) 57% of the time (d2?
Negative_regulation (closed) of d2
17) Confidence 0.03 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2867933 Disease Relevance 0 Pain Relevance 0
Other receptors negatively coupled to adenylyl cyclase, namely, D2-dopaminergic, alpha 2-adrenergic, and m2/m4-muscarinic, were identified by screening of these cells, and it was shown that prolonged treatment (2 h) with 1 microM 2-bromo-alpha-ergocryptine or 1 microM arterenol resulted in a marked desensitization of D2-dopaminergic and alpha 2-adrenergic receptors, respectively.
Negative_regulation (desensitization) of D2-dopaminergic
18) Confidence 0.01 Published 1997 Journal J. Neurochem. Section Abstract Doc Link 9084451 Disease Relevance 0.15 Pain Relevance 0.30
As demonstrated by the D-Ala2,N-MePhe4,Gl-ol5-enkephalin (DAMGO)-induced inhibition of intracellular cAMP level and by binding studies, the co-expression of mGluR5 had no substantial effect on the agonist binding sites and functional coupling of the MOR.
Negative_regulation (inhibition) of D-Ala2 associated with agonist, opioid receptor and enkephalin
19) Confidence 0.00 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19162047 Disease Relevance 0 Pain Relevance 0.92

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox