INT3631

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Context Info
Confidence 0.48
First Reported 1976
Last Reported 1995
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 0.56
Pain Relevance 2.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Trh, tsh) extracellular region (Trh) plasma membrane (Trh)
cytoplasm (Trh)
Anatomy Mention Frequency
thyroid 2
Trh (Rattus norvegicus)
tsh (Drosophila melanogaster)
Pain Term Frequency Confidence Heat
Morphine 9 99.60 Very High Very High Very High
Dopamine 1 98.28 Very High Very High Very High
Paracetamol 5 98.00 Very High Very High Very High
Clonidine 5 97.72 Very High Very High Very High
Opioid 4 96.84 Very High Very High Very High
narcan 4 95.68 Very High Very High Very High
agonist 3 91.76 High High
Somatostatin 1 85.20 High High
anesthesia 2 78.88 Quite High
cINOD 1 72.28 Quite High
Disease Term Frequency Confidence Heat
Thyroid Disease 2 75.00 Quite High
Stress 4 75.00 Quite High
INFLAMMATION 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apomorphine attenuated exogenous TRH-induced TSH release in both neonatal and adult rats.
TRH Positive_regulation (induced) of Localization (release) of TSH
1) Confidence 0.48 Published 1988 Journal Endocrinology Section Abstract Doc Link 3133201 Disease Relevance 0 Pain Relevance 0.54
TRH-induced TSH secretion was not influenced by indomethacin, ibuprofen or paracetamol treatment.
TRH Positive_regulation (induced) of Localization (secretion) of TSH associated with paracetamol
2) Confidence 0.45 Published 1988 Journal Gen. Pharmacol. Section Abstract Doc Link 3410280 Disease Relevance 0 Pain Relevance 0.35
Pretreatment with morphine did not reduce the release of TSH induced by exogenous thyrotrophin-releasing hormone (TRH) but enhanced it.
TRH Positive_regulation (induced) of Localization (release) of TSH associated with morphine
3) Confidence 0.44 Published 1980 Journal J. Endocrinol. Section Abstract Doc Link 6776217 Disease Relevance 0 Pain Relevance 0.64
In contrast, TRH-induced TSH release was enhanced (P less than 0.001) in the euthyroid cultures. [3H]Dihydroergocryptine [( 3H]DHE) was used to quantify alpha 1-adrenoreceptors on the same cell preparations as those used to derive the functional data (see above).
TRH Positive_regulation (induced) of Localization (release) of TSH
4) Confidence 0.42 Published 1985 Journal Endocrinology Section Abstract Doc Link 2990855 Disease Relevance 0 Pain Relevance 0.07
T3 1 and 100 nmol/L inhibited TRH-stimulated TSH release by 24% and 31%, respectively (P < .001), whereas TRH-stimulated TSH release was inhibited by 100 mumol/L meclofenamic acid (29%), fenclofenac (28%), furosemide (24%), and diphenylhydantoin (48%) (P < .001 v TRH alone).
TRH-stimulated Positive_regulation (stimulated) of Localization (release) of TSH
5) Confidence 0.41 Published 1995 Journal Metab. Clin. Exp. Section Abstract Doc Link 7637641 Disease Relevance 0.15 Pain Relevance 0.07
These results suggest that altered thyroid status influences GH release as well as TSH secretion induced by TRH in rats.
TRH Positive_regulation (induced) of Localization (secretion) of TSH in thyroid
6) Confidence 0.17 Published 1976 Journal Endocrinology Section Abstract Doc Link 819251 Disease Relevance 0.15 Pain Relevance 0.08
Stimulation of TSH secretion was similar in response to thyrotropin-releasing hormone (TRH) in INDO-treated and control rats and was also similar in response to PGE2 in INDO- and DDC-treated rats.
TRH Positive_regulation (Stimulation) of Localization (secretion) of TSH
7) Confidence 0.12 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6504267 Disease Relevance 0 Pain Relevance 0.49
It is known that TRH not only stimulates TSH secretion but will stimulate prolactin secretion as well.
TRH Positive_regulation (stimulates) of Localization (secretion) of TSH
8) Confidence 0.03 Published 1980 Journal Neuroendocrinology Section Abstract Doc Link 6775240 Disease Relevance 0.27 Pain Relevance 0.05
The effect of beta-endorphin on basal and TRH-stimulated TSH release in conscious male rats.
TRH-stimulated Positive_regulation (stimulated) of Localization (release) of TSH
9) Confidence 0.02 Published 1988 Journal Horm. Metab. Res. Section Title Doc Link 2975264 Disease Relevance 0 Pain Relevance 0.18

General Comments

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