INT36314

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Context Info
Confidence 0.73
First Reported 1986
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 6.21
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (FGFR3) cytoplasmic membrane-bounded vesicle (FGFR3) plasma membrane (FGFR3)
Anatomy Link Frequency
muscle 2
neuronal 1
blood vessels 1
TMJ 1
fibroblast 1
FGFR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 8 99.36 Very High Very High Very High
Action potential 6 98.20 Very High Very High Very High
Snapping jaw 11 97.96 Very High Very High Very High
Neurotransmitter 3 96.76 Very High Very High Very High
depression 26 86.24 High High
cytokine 2 84.24 Quite High
backache 9 77.00 Quite High
anesthesia 7 75.00 Quite High
Pain 30 73.24 Quite High
imagery 3 69.64 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 6 99.78 Very High Very High Very High
Autoimmune Disease 1 99.60 Very High Very High Very High
Myasthenia Gravis 2 99.10 Very High Very High Very High
Primary Sclerosing Cholangitis 16 99.04 Very High Very High Very High
Hypersensitivity 4 98.40 Very High Very High Very High
Temporomandibular Joint Syndrome 11 97.96 Very High Very High Very High
Disease 20 97.88 Very High Very High Very High
Synovial Chondromatosis 14 97.12 Very High Very High Very High
Glioma 3 93.36 High High
Congenital Anomalies 3 86.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, expression of TGFbetaRII, FGFR3 and IGFRI, but not BMP RII, were observed in the ingrowing blood vessels that characterize part of the disease aetiology.
Gene_expression (expression) of FGFR3 in blood vessels associated with disease
1) Confidence 0.73 Published 2005 Journal J. Pathol. Section Abstract Doc Link 16278806 Disease Relevance 0.22 Pain Relevance 0.09
Myasthenia gravis is an autoimmune disease resulting from the production of antibodies against the ACh receptors of the neuromuscular synapse.
Gene_expression (production) of ACh in synapse associated with autoimmune disease and myasthenia gravis
2) Confidence 0.65 Published 2001 Journal Chest Surg. Clin. N. Am. Section Abstract Doc Link 11413760 Disease Relevance 0.45 Pain Relevance 0.07
This immunohistochemical study has for the first time investigated the expression and localization of four potentially beneficial growth factor receptors (i.e.
Gene_expression (expression) of FGFR3
3) Confidence 0.63 Published 2005 Journal J. Pathol. Section Abstract Doc Link 16278806 Disease Relevance 0.36 Pain Relevance 0.26
The developmentally regulated expression and distribution of FGFRs, especially FGFR3, play a role in muscle maturation [28].
Gene_expression (expression) of FGFR3 in muscle
4) Confidence 0.61 Published 2005 Journal Genome Biol Section Body Doc Link PMC1088952 Disease Relevance 0.51 Pain Relevance 0.13
In mammalian muscles, experimental denervation induces the appearance of extrajunctional acetylcholine (ACh) receptors and tetrodotoxin (TTX) resistant action potentials (AP).
Gene_expression (appearance) of ACh in muscles associated with action potential and tetrodotoxin
5) Confidence 0.58 Published 1986 Journal Muscle Nerve Section Abstract Doc Link 3785285 Disease Relevance 0.43 Pain Relevance 0.49
The other major membrane phospholipids, phosphatidylserine and phosphatidylethanolamine, also decline proportionately to PC when slices are stimulated in the absence of choline. 2) In a population of purely cholinergic cells (human neuroblastoma, LA-N-2), ACh can be synthesized from choline derived from degradation of endogenous PC formed de novo by methylation of phosphatidylethanolamine. 3) PC content of cells in culture (neuroblastoma X glioma hybrid, NG 108-15) can be altered by adding various amounts of choline to the growth media.
Gene_expression (synthesized) of ACh associated with neuroblastoma and glioma
6) Confidence 0.50 Published 1987 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 3316498 Disease Relevance 0.34 Pain Relevance 0.12
Taken together these data demonstrate that cholinergic neurons utilize the choline stored in PC to synthesize ACh; that this process may lead to a depletion in membrane phospholipids (when choline supply is inadequate); and that the resulting changes in neuronal membrane composition might adversely affect cellular viability.
Gene_expression (synthesize) of ACh in neuronal
7) Confidence 0.50 Published 1987 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 3316498 Disease Relevance 0.26 Pain Relevance 0.07
A prolonged utilization of choline liberated from PC, for ACh production, without adequate resynthesis of this lipid, might result in a net loss of the phosphatide followed by an impairment of membrane function and loss of cellular viability.
Gene_expression (production) of ACh
8) Confidence 0.50 Published 1987 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 3316498 Disease Relevance 0.09 Pain Relevance 0.10
It was reported recently that expression of fibroblast growth factor receptor-3 (FGFR-3) was observed specifically in PSC.
Gene_expression (expression) of FGFR-3 in fibroblast associated with primary sclerosing cholangitis
9) Confidence 0.37 Published 2004 Journal Arch. Oral Biol. Section Abstract Doc Link 15126141 Disease Relevance 1.50 Pain Relevance 0.31
FGFR-3 was found in all three phases of PSC, but not in SSC, ID or normal TMJ.
Neg (not) Gene_expression (found) of FGFR-3 in TMJ associated with snapping jaw, hypersensitivity and primary sclerosing cholangitis
10) Confidence 0.37 Published 2004 Journal Arch. Oral Biol. Section Abstract Doc Link 15126141 Disease Relevance 1.85 Pain Relevance 0.43
The cortisol levels came down while Prolactin and Ach levels increased).
Gene_expression (levels) of Ach
11) Confidence 0.19 Published 2010 Journal Indian Journal of Palliative Care Section Body Doc Link PMC2936076 Disease Relevance 0.20 Pain Relevance 0.16

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