INT36320

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Context Info
Confidence 0.00
First Reported 1987
Last Reported 1987
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.61

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extracellular region (PDYN, Ctsb) mitochondrion (Ctsb) response to stress (Ctsb)
cytoplasm (Ctsb) peptidase activity (Ctsb) extracellular space (Ctsb)
PDYN (Homo sapiens)
Ctsb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 5 100.00 Very High Very High Very High
Dynorphin 3 100.00 Very High Very High Very High
Opioid 1 75.00 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data obtained suggest that Arg residue at the position P2 (dynorphin 1-7) slowed down, D-amino acid at the position P2 (D-Ala2, D-Leu5-enkephalin) and Pro-Lys bond at the position P1-P2 (dynorphin 1-11) inhibited the cathepsin B dipeptidyl carboxypeptidase activity.
D-Leu5-enkephalin Negative_regulation (inhibited) of cathepsin B associated with dynorphin and enkephalin
1) Confidence 0.00 Published 1987 Journal Vopr. Med. Khim. Section Abstract Doc Link 3318115 Disease Relevance 0 Pain Relevance 0.61

General Comments

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