INT36325

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Context Info
Confidence 0.05
First Reported 1987
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.73
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Hmgcl) lyase activity (Hmgcl) mitochondrion organization (Hmgcl)
peroxisome (Hmgcl) embryo development (Hmgcl)
Anatomy Link Frequency
liver 1
Hmgcl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 2 99.72 Very High Very High Very High
Pain 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cirrhosis 2 98.44 Very High Very High Very High
Disease 2 97.74 Very High Very High Very High
Coma 3 79.28 Quite High
Hypoglycemia 3 78.80 Quite High
Muscle Disease 1 73.60 Quite High
Coronary Heart Disease 1 71.76 Quite High
Fatty Liver 1 68.64 Quite High
Rhabdomyolysis 1 25.00 Low Low
Toxicity 1 25.00 Low Low
Hypertrophic Cardiomyopathy 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There are now nine inherited diseases that have been identified in the pathway of mitochondrial fatty acid oxidation, including LCAD, MCAD, SCAD, and HMG-CoA lyase deficiencies, two forms each of CPT and MAD deficiencies and an incompletely characterized disorder of primary carnitine deficiency.
Negative_regulation (deficiencies) of HMG-CoA lyase associated with disease
1) Confidence 0.05 Published 1987 Journal Adv Pediatr Section Abstract Doc Link 3318304 Disease Relevance 0.55 Pain Relevance 0
Patients after liver transplantation and patients with liver cirrhosis show significantly higher plasma endothelin concentrations and significantly reduced results in the quantitative liver function tests (ICG-HL, GEC, Lidocaine-HL, MEGX) compared with healthy control persons.
Negative_regulation (reduced) of ICG-HL in liver associated with cirrhosis and lidocaine
2) Confidence 0.01 Published 1993 Journal Med. Klin. (Munich) Section Abstract Doc Link 8474403 Disease Relevance 0.17 Pain Relevance 0.18

General Comments

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