INT36335

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Context Info
Confidence 0.79
First Reported 1987
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 19
Total Number 19
Disease Relevance 7.06
Pain Relevance 4.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Tgfb1) enzyme binding (Tgfb1) embryo development (Tgfb1)
cytoplasm (Tgfb1) cell proliferation (Tgfb1) extracellular space (Tgfb1)
Anatomy Link Frequency
PSCs 5
lymph node 1
projection neurons 1
plaques 1
Th2 cells 1
Tgfb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
projection neuron 1 99.48 Very High Very High Very High
Enkephalin 2 99.36 Very High Very High Very High
fibrosis 19 99.16 Very High Very High Very High
Neuritis 14 97.44 Very High Very High Very High
amygdala 1 97.36 Very High Very High Very High
Angina 1 97.32 Very High Very High Very High
Sciatic nerve 4 97.20 Very High Very High Very High
cytokine 11 97.16 Very High Very High Very High
parabrachial 1 94.28 High High
Peripheral nervous system 2 92.80 High High
Disease Link Frequency Relevance Heat
Fibrosis 23 99.16 Very High Very High Very High
Fracture Healing 12 98.20 Very High Very High Very High
Primary Sclerosing Cholangitis 9 97.98 Very High Very High Very High
Experimental Autoimmune Neuritis 14 97.44 Very High Very High Very High
Cv General 3 Under Development 1 97.32 Very High Very High Very High
Disease 16 97.30 Very High Very High Very High
Myocardial Infarction 1 96.28 Very High Very High Very High
Immunization 2 95.66 Very High Very High Very High
Injury 2 95.12 Very High Very High Very High
Acute Coronary Syndrome 4 94.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Local and systemic release of transforming growth factor beta 1 (TGF-beta1) is known to increase during the process of fracture healing and this cytokine stimulates bone healing.
Localization (release) of TGF-beta1 associated with fracture healing and cytokine
1) Confidence 0.79 Published 2006 Journal Life Sci. Section Abstract Doc Link 17023006 Disease Relevance 0.47 Pain Relevance 0.25
Local and systemic release of transforming growth factor beta 1 (TGF-beta1) is known to increase during the process of fracture healing and this cytokine stimulates bone healing.
Localization (release) of transforming growth factor beta 1 associated with fracture healing and cytokine
2) Confidence 0.79 Published 2006 Journal Life Sci. Section Abstract Doc Link 17023006 Disease Relevance 0.47 Pain Relevance 0.25
The effects of transforming growth factor-beta 1 (TGF-beta 1) on the clinical signs, histological changes, cell-mediated immune responses, and secretion of interferon-gamma (IFN-gamma) by lymphoid cells of rats with EAN were examined.
Localization (secretion) of TGF-beta 1 associated with neuritis
3) Confidence 0.74 Published 1994 Journal Cell. Immunol. Section Abstract Doc Link 7515330 Disease Relevance 0.87 Pain Relevance 0.52
The effects of transforming growth factor-beta 1 (TGF-beta 1) on the clinical signs, histological changes, cell-mediated immune responses, and secretion of interferon-gamma (IFN-gamma) by lymphoid cells of rats with EAN were examined.
Localization (secretion) of transforming growth factor-beta 1 associated with neuritis
4) Confidence 0.65 Published 1994 Journal Cell. Immunol. Section Abstract Doc Link 7515330 Disease Relevance 0.88 Pain Relevance 0.52
Expression of collagen was also examined while transforming growth factor-beta-1 (TGF-beta(1)) was localized by immunochemistry.
Localization (localized) of transforming growth factor-beta-1
5) Confidence 0.63 Published 2007 Journal World J. Gastroenterol. Section Body Doc Link 17230605 Disease Relevance 0.15 Pain Relevance 0
There is evidence indicating that these profibrotic factors interact with antifibrotic defense mechanisms, such as decrease of myofibroblast accumulation, elimination of reactive oxygen species by inducible nitric oxide synthase and neutralization of transforming-growth-factor beta1 by decorin, such that some plaques are in dynamic turnover.
Localization (neutralization) of transforming-growth-factor beta1 in plaques
6) Confidence 0.49 Published 2005 Journal Nature clinical practice. Urology Section Abstract Doc Link 16474811 Disease Relevance 1.36 Pain Relevance 0.14
In addition, Leu-enkephalin immunoreactivity (L-ENK-I) was colocalized with TGF alpha-I in the same projection neurons after the injections described above.
Localization (colocalized) of TGF alpha-I in projection neurons associated with projection neuron and enkephalin
7) Confidence 0.47 Published 1987 Journal Brain Res. Section Abstract Doc Link 3319040 Disease Relevance 0 Pain Relevance 0.81
The localizations of TGF-beta1 mRNA and protein were confirmed in the cytoplasm of pancreatic acinar and ductal cells by in situ hybridization and immunohistochemistry, respectively.
Localization (localizations) of TGF-beta1 mRNA
8) Confidence 0.45 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10695628 Disease Relevance 0.58 Pain Relevance 0.52
Concentration of activated transforming growth factor-beta1 (TGF-beta1) secreted from PSCs into culture medium was determined by ELISA.
Localization (secreted) of TGF-beta1 in PSCs
9) Confidence 0.25 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15319186 Disease Relevance 0.15 Pain Relevance 0.11
Concentration of activated transforming growth factor-beta1 (TGF-beta1) secreted from PSCs into culture medium was determined by ELISA.
Localization (secreted) of transforming growth factor-beta1 in PSCs
10) Confidence 0.25 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15319186 Disease Relevance 0.15 Pain Relevance 0.11
Moreover, pressure significantly promoted activated TGF-beta1 secretion, collagen type I mRNA expression, and collagen secretion.
Localization (secretion) of TGF-beta1
11) Confidence 0.25 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15319186 Disease Relevance 0 Pain Relevance 0.12
Moreover, pressure significantly promoted activated TGF-beta1 secretion, collagen type I mRNA expression, and collagen secretion.
Localization (secretion) of TGF-beta1
12) Confidence 0.22 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15319186 Disease Relevance 0 Pain Relevance 0.13
Type I collagen and transforming growth factor-beta1 secretion was evaluated by ELISA, and matrix metalloproteinase activity was assessed by gelatin zymography.
Localization (secretion) of growth factor-beta1
13) Confidence 0.17 Published 2008 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 17764527 Disease Relevance 0 Pain Relevance 0
T helper cell type 3 (Th3), which primarily secretes transforming growth factor beta-1 (TGF-beta1), has been shown to inhibit both Th1 and Th2 cells.
Localization (secretes) of transforming growth factor beta-1 in Th2 cells
14) Confidence 0.12 Published 2009 Journal Arch. Med. Res. Section Abstract Doc Link 19608018 Disease Relevance 0.55 Pain Relevance 0.10
IL-6 as well as IL-1beta enhanced TGF-beta1 secretion from PSCs.
Localization (secretion) of TGF-beta1 in PSCs
15) Confidence 0.09 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837651 Disease Relevance 0.23 Pain Relevance 0.11
Furthermore, IL-1beta and IL-6 promote PSC activation by enhancing COX-2 expression indirectly through Smad2/3-dependent pathway by increasing TGF-beta1 secretion from PSCs.
Localization (secretion) of TGF-beta1 in PSCs associated with primary sclerosing cholangitis
16) Confidence 0.09 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837651 Disease Relevance 0.22 Pain Relevance 0.10
EGCG also suppressed ethanol-induced p38 mitogen-activated protein (MAP) kinase phosphorylation, alpha-smooth muscle actin production in PSCs and activated transforming growth factor-beta1 secretion into the medium.
Localization (secretion) of transforming growth factor-beta1 in PSCs
17) Confidence 0.08 Published 2006 Journal Eur. J. Clin. Invest. Section Body Doc Link 16436093 Disease Relevance 0.07 Pain Relevance 0
On the 14th day after immunization, we examined lymphocyte proliferation, fractions of CD4+ T cells within lymph node mononuclear cells (MNC), frequencies of CD4+CD25+ T cells within CD4+ T cells, supernatant productions of IFN-gamma, IL-4, IL-10 and TGF-beta1 secreted by lymphocytes.
Localization (secreted) of TGF-beta1 in mononuclear cells associated with immunization
18) Confidence 0.08 Published 2007 Journal J. Neuroimmunol. Section Abstract Doc Link 17346805 Disease Relevance 0.33 Pain Relevance 0.12
Our findings indicated: (1) 100 microg of P2 peptide 57-81 and 200 microg of P0 peptide 180-199 may induce an acute EAN and 200 microg of P2 peptide 57-81 may induce a chronic EAN; (2) Lewis rats were more sensitive to P2 peptide 57-81 than P0 peptide 180-199; (3) clinical disease had nothing to do with a change of relative CD4+ T cells number in lymph node MNC; (4) frequencies of CD4+CD25+ T cells and levels of TGF-beta1 secreted by lymphocytes negatively paralleled clinical EAN, while levels of IFN-gamma secreted by lymphocytes roughly paralleled clinical EAN at the acute phase; (5) sciatic nerve sections from the chronic EAN rats didn't show any inflammatory cells, but showed remaining segmental demyelination and axonal collapse at the chronic phase; (6) self-limitation of acute EAN may owe to the rising levels of IL-4 and IL-10, while a longer duration of chronic EAN may owe to the decreasing levels of IL-4 and IL-10.
Neg (negatively) Localization (secreted) of TGF-beta1 in lymph node associated with demyelination, inflammation, shock, sciatic nerve and disease
19) Confidence 0.08 Published 2007 Journal J. Neuroimmunol. Section Abstract Doc Link 17346805 Disease Relevance 0.58 Pain Relevance 0.25

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