INT36336

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Context Info
Confidence 0.77
First Reported 1987
Last Reported 2010
Negated 0
Speculated 4
Reported most in Abstract
Documents 41
Total Number 45
Disease Relevance 21.82
Pain Relevance 14.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Tgfb1) enzyme binding (Tgfb1) embryo development (Tgfb1)
cytoplasm (Tgfb1) cell proliferation (Tgfb1) extracellular space (Tgfb1)
Anatomy Link Frequency
smooth muscle 6
pancreas 4
stellate cells 3
epithelial cells 2
mononuclear cell 2
Tgfb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 173 100.00 Very High Very High Very High
cytokine 33 100.00 Very High Very High Very High
metalloproteinase 244 99.94 Very High Very High Very High
acular 4 99.50 Very High Very High Very High
Chronic pancreatitis 86 99.46 Very High Very High Very High
Inflammation 91 99.36 Very High Very High Very High
Nerve growth factor 2 99.16 Very High Very High Very High
Raphe magnus 1 98.76 Very High Very High Very High
Raphe 2 98.20 Very High Very High Very High
spinal inflammation 2 97.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Fibrosis 146 100.00 Very High Very High Very High
Pancreatitis 106 100.00 Very High Very High Very High
Pulmonary Fibrosis 56 100.00 Very High Very High Very High
Targeted Disruption 4 99.88 Very High Very High Very High
INFLAMMATION 88 99.36 Very High Very High Very High
Disease 98 98.96 Very High Very High Very High
Injury 58 98.08 Very High Very High Very High
Osteoporosis 5 97.88 Very High Very High Very High
Hypertrophy 2 97.40 Very High Very High Very High
Low Back Pain 2 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-1beta and TGF-beta1 expression was also measured.
Gene_expression (expression) of TGF-beta1
1) Confidence 0.77 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10673357 Disease Relevance 0.08 Pain Relevance 0.24
The expression of IL-1beta and TGF-beta1 in the right dorsal root ganglia was significantly higher in the experimental group.
Gene_expression (expression) of TGF-beta1 in dorsal root ganglia
2) Confidence 0.77 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10673357 Disease Relevance 0.09 Pain Relevance 0.25
The protective effects were confirmed by an increase in pancreatic weight and decreases in myeloperoxidase activity (an index of neutrophil infiltration), collagen content, transforming growth factor-beta1 expression, and the number of alpha-smooth muscle actin-positive cells (activated pancreatic stellate cells) and ED-1-positive cells (macrophages/monocytes).
Gene_expression (expression) of transforming growth factor-beta1 in neutrophil
3) Confidence 0.51 Published 2009 Journal Dig. Dis. Sci. Section Abstract Doc Link 18651219 Disease Relevance 0.80 Pain Relevance 0.47
Injury to the erect penis is thought to trigger PD by inducing extravasation of fibrin and subsequent synthesis of transforming-growth-factor beta1.
Gene_expression (synthesis) of transforming-growth-factor beta1 in penis associated with injury and disease
4) Confidence 0.51 Published 2005 Journal Nature clinical practice. Urology Section Abstract Doc Link 16474811 Disease Relevance 1.35 Pain Relevance 0.14
Transforming growth factor-beta1 (TGF-beta1) is suggested to be a mediator of fibrosis in chronic pancreatitis, but the serial change of TGF-beta1 expression in the onset and progression of chronic pancreatitis is still unclear.
Gene_expression (expression) of TGF-beta1 associated with fibrosis and chronic pancreatitis
5) Confidence 0.43 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10695628 Disease Relevance 0.53 Pain Relevance 0.45
We investigated the TGF-beta1 expression in the spontaneous chronic pancreatitis model.
Spec (investigated) Gene_expression (expression) of TGF-beta1 associated with chronic pancreatitis
6) Confidence 0.43 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10695628 Disease Relevance 0.54 Pain Relevance 0.45
Pancreatic fibrosis peaked at 16 weeks after the peak of TGF-beta1 expression.
Gene_expression (expression) of TGF-beta1 associated with fibrosis
7) Confidence 0.43 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10695628 Disease Relevance 0.53 Pain Relevance 0.50
These results suggest that TGF-beta1 expression may be a trigger of the fibrotic process of chronic pancreatitis in the WBN/Kob rat.
Gene_expression (expression) of TGF-beta1 associated with fibrosis and chronic pancreatitis
8) Confidence 0.43 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10695628 Disease Relevance 0.71 Pain Relevance 0.49
This hypothesis is supported by data in the literature showing enhanced TGFbeta expression in human chronic pancreatitis (2) and development of fibrosis and inflammation in pancreata of transgenic mice overexpressing TGFbeta1 (3).
Gene_expression (overexpressing) of TGFbeta1 associated with targeted disruption, fibrosis, inflammation and chronic pancreatitis
9) Confidence 0.42 Published 1999 Journal Hepatogastroenterology Section Abstract Doc Link 10576340 Disease Relevance 0.86 Pain Relevance 0.37
Neurons that contain both TGF alpha-I and FG were also found in the raphe magnus, raphe obscurus, raphe pallidus and the gigantocellularis reticular nuclei after FG injections in the upper thoracic spinal cord.
Gene_expression (contain) of TGF alpha-I in spinal cord associated with raphe magnus, raphe and spinal cord
10) Confidence 0.38 Published 1987 Journal Brain Res. Section Abstract Doc Link 3319040 Disease Relevance 0 Pain Relevance 0.75
In untreated WBN/Kob rats, chronic pancreatitis developed at 12 weeks and progressed with marked fibrosis at 16 weeks, and the expression of TGF-beta1 and FN peaked at 12 weeks.
Gene_expression (expression) of TGF-beta1 associated with fibrosis and chronic pancreatitis
11) Confidence 0.37 Published 2001 Journal Pancreas Section Abstract Doc Link 11138977 Disease Relevance 0.83 Pain Relevance 0.57
These results suggest that TJ-10 inhibits the pancreatic fibrosis by the suppression of TGF-beta1 expression.
Gene_expression (expression) of TGF-beta1 associated with fibrosis
12) Confidence 0.37 Published 2001 Journal Pancreas Section Abstract Doc Link 11138977 Disease Relevance 0.81 Pain Relevance 0.51
However, in the TJ-10-treated rats, the rate of pancreatic fibrosis and the expression of TGF-beta1, FN, alpha-SMA, and type III collagen at 12 and 16 weeks decreased significantly compared to those in the untreated rats.
Gene_expression (expression) of TGF-beta1 associated with fibrosis
13) Confidence 0.37 Published 2001 Journal Pancreas Section Abstract Doc Link 11138977 Disease Relevance 0.80 Pain Relevance 0.55
Pancreata were histopathologically examined at every 4 weeks, and the expression of fibrosis-related factors such as transforming growth factor beta1 (TGF-beta1), fibronectin (FN), alpha-smooth muscle actin (alpha-SMA), and type III collagen was analyzed.
Spec (analyzed) Gene_expression (expression) of transforming growth factor beta1 in smooth muscle associated with fibrosis
14) Confidence 0.37 Published 2001 Journal Pancreas Section Abstract Doc Link 11138977 Disease Relevance 0.86 Pain Relevance 0.58
Pancreata were histopathologically examined at every 4 weeks, and the expression of fibrosis-related factors such as transforming growth factor beta1 (TGF-beta1), fibronectin (FN), alpha-smooth muscle actin (alpha-SMA), and type III collagen was analyzed.
Spec (analyzed) Gene_expression (expression) of TGF-beta1 in smooth muscle associated with fibrosis
15) Confidence 0.37 Published 2001 Journal Pancreas Section Abstract Doc Link 11138977 Disease Relevance 0.86 Pain Relevance 0.58
OBJECTIVES: To study serum levels of transforming growth factor beta-1 (TGFbeta1) and the expression of TGFbeta1 in in vitro peripheral blood mononuclear cell (PBMC) cultures in oriental ankylosing spondylitis (AS) patients, and to determine their association with codon 10 and 25 TGFB1 gene polymorphisms.
Gene_expression (expression) of transforming growth factor beta-1 in mononuclear cell associated with spinal inflammation
16) Confidence 0.35 Published 2005 Journal Rheumatology (Oxford) Section Abstract Doc Link 15479754 Disease Relevance 0.17 Pain Relevance 0.17
TGF-beta1 mRNA in the pancreas was detected by reverse transcription-polymerase chain reaction assay from four weeks, and its expression peaked at 12 weeks when the pancreatic fibrosis first appeared.
Gene_expression (detected) of TGF-beta1 mRNA in pancreas associated with fibrosis
17) Confidence 0.34 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10695628 Disease Relevance 0.59 Pain Relevance 0.47
Although fibronectin expression peaked at 12 weeks and correlated with that of TGF-beta1, its elevated expression tended to be prolonged.
Gene_expression (expression) of TGF-beta1
18) Confidence 0.34 Published 2000 Journal Dig. Dis. Sci. Section Abstract Doc Link 10695628 Disease Relevance 0.56 Pain Relevance 0.51
In rats treated with maximal doses of cerulein and TGFbeta antibodies, pancreatic hydroxyproline content and expression of collagens I and III and of TGFbeta1 were significantly reduced.
Gene_expression (expression) of TGFbeta1
19) Confidence 0.32 Published 1999 Journal Hepatogastroenterology Section Abstract Doc Link 10576340 Disease Relevance 0.56 Pain Relevance 0.13
High doses of lisinopril suppressed the overexpression of TGF-beta1 mRNA measured by reverse-transcription polymerase chain reaction (RT-PCR) and decreased the number of alpha-SMA-positive cells (activated pancreatic stellate cells) in the pancreas.
Gene_expression (overexpression) of TGF-beta1 mRNA in pancreas
20) Confidence 0.30 Published 2003 Journal Gastroenterology Section Body Doc Link 12671898 Disease Relevance 0.06 Pain Relevance 0

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