INT36338

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Context Info
Confidence 0.67
First Reported 1987
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 29
Total Number 29
Disease Relevance 6.47
Pain Relevance 2.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NRP2) cell adhesion (NRP2) plasma membrane (NRP2)
Anatomy Link Frequency
nervous system 3
neural 3
synovial fluid 1
neuronal 1
respiratory systems 1
NRP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 8 99.28 Very High Very High Very High
rheumatoid arthritis 65 99.12 Very High Very High Very High
Thoracotomy 6 97.88 Very High Very High Very High
Angina 8 97.68 Very High Very High Very High
ischemia 2 97.68 Very High Very High Very High
diabetic neuropathy 5 97.52 Very High Very High Very High
Pain 68 97.48 Very High Very High Very High
Osteoarthritis 3 95.52 Very High Very High Very High
Bioavailability 1 94.32 High High
Neuropeptide 7 89.44 High High
Disease Link Frequency Relevance Heat
Intervertebral Disk Degeneration 21 99.90 Very High Very High Very High
Rheumatoid Arthritis 67 99.12 Very High Very High Very High
Injury 21 98.76 Very High Very High Very High
Coronary Artery Disease 11 98.12 Very High Very High Very High
Neurological Disease 5 97.84 Very High Very High Very High
Cv General 3 Under Development 9 97.68 Very High Very High Very High
Diabetic Neuropathy 5 97.52 Very High Very High Very High
Pain 49 97.48 Very High Very High Very High
Malignant Neoplastic Disease 4 97.00 Very High Very High Very High
Osteoarthritis 3 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One-year follow-up of direct myocardial gene transfer of vascular endothelial growth factor-2 using naked plasmid deoxyribonucleic acid by way of thoracotomy in no-option patients.
Gene_expression (transfer) of vascular endothelial growth factor-2 associated with thoracotomy
1) Confidence 0.67 Published 2003 Journal Am. J. Cardiol. Section Title Doc Link 12914874 Disease Relevance 0.09 Pain Relevance 0.18
Dual-stained cells expressing CD34 and vascular endothelial growth factor receptor-2 were judged to be endothelial progenitor cells and were analyzed using flow cytometry.
Gene_expression (expressing) of vascular endothelial growth factor receptor-2
2) Confidence 0.61 Published 2008 Journal Heart Vessels Section Abstract Doc Link 18273546 Disease Relevance 0.62 Pain Relevance 0.10
This phase I open label, dose-escalating study shows that gene transfer of vascular endothelial growth factor-2 naked deoxyribonucleic acid by direct myocardial injection by way of thoracotomy in patients with Canadian Cardiovascular Society class 3 or 4 angina is feasible and safe.
Gene_expression (transfer) of vascular endothelial growth factor-2 associated with angina and thoracotomy
3) Confidence 0.60 Published 2003 Journal Am. J. Cardiol. Section Abstract Doc Link 12914874 Disease Relevance 0.09 Pain Relevance 0.18
A randomized phase III trial is underway that will help determine the efficacy of vascular endothelial growth factor-2 gene transfer in "no-option" patients.
Gene_expression (transfer) of vascular endothelial growth factor-2 gene
4) Confidence 0.60 Published 2003 Journal Am. J. Cardiol. Section Abstract Doc Link 12914874 Disease Relevance 0.08 Pain Relevance 0.16
As IVD cells are phenotypically similar to chondrocytes [48] we hypothesised that cells of the healthy IVD may express semaphorins as a means of repelling neurovascular invasion, and in disc degeneration the expression of semaphorins may be reduced causing a disinhibition of neural and vascular ingrowth.
Gene_expression (expression) of semaphorins in neural associated with intervertebral disk degeneration
5) Confidence 0.51 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0.17 Pain Relevance 0
For example, of the 59 tokens of the transitive present participial adjective alternation, 20 of those tokens fit the pattern NP1-containing NP2, where the semantic relation is that NP2 contains NP1.
Gene_expression (contains) of NP2
6) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527518 Disease Relevance 0 Pain Relevance 0.04
As IVD cells are phenotypically similar to chondrocytes [48] we hypothesised that cells of the healthy IVD may express semaphorins as a means of repelling neurovascular invasion, and in disc degeneration the expression of semaphorins may be reduced causing a disinhibition of neural and vascular ingrowth.
Gene_expression (express) of semaphorins in neural associated with intervertebral disk degeneration
7) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0.17 Pain Relevance 0
Aliqouts of cDNA were subjected to PCR using primers specific for the house-keeping gene GAPDH, as well as sema3A, sema3F, NRP-1, NRP-2, PLXA1, PLXA2, PLXA3, PLXA4 and PGP9.5 (Table 1).
Gene_expression (as) of NRP-2
8) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0 Pain Relevance 0
For example, of the 59 tokens of the transitive present participial adjective alternation, 20 of those tokens fit the pattern NP1-containing NP2, where the semantic relation is that NP2 contains NP1.
Gene_expression (containing) of NP2
9) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527518 Disease Relevance 0 Pain Relevance 0.04
NRP-2 expression was observed in both healthy and degenerate NP samples with four healthy NP, degenerate AF and degenerate NP samples demonstrating positivity, albeit at differing levels.
Gene_expression (expression) of NRP-2
10) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0 Pain Relevance 0
Data provided from the RT-PCR results have shown that the disc cells express a number of candidate receptors for the Class 3 semaphorins.
Gene_expression (express) of semaphorins
11) Confidence 0.39 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875625 Disease Relevance 0.32 Pain Relevance 0
This study aimed to identify whether members of the Class 3 semaphorins were expressed by chondrocyte-like cells of the IVD addressing the hypothesis that they may play a role in repelling axons surrounding the healthy disc, thus maintaining its aneural condition.


Gene_expression (expressed) of semaphorins in IVD
12) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875625 Disease Relevance 0.26 Pain Relevance 0.17
This study is the first to establish the expression of semaphorins and their receptors in the human IVD with a decrease seen in the degenerate painful IVD.
Gene_expression (expression) of semaphorins associated with pain
13) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2875625 Disease Relevance 0 Pain Relevance 0.10
More interestingly, in comparison of genes associated during neural differentiation process of human embryonic stem cells or human brain with our results, we also found increased expression of PENK, STK4, IGFBP4, Slc17a6, Slc6A1, Nurr1, Nrp2, Moxd1, Shh and Neurod2 [36,37].
Gene_expression (expression) of Nrp2 in neural
14) Confidence 0.31 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.07 Pain Relevance 0
For the first time, a defective recombinant vector (NP2) expressing preproenkephalin is now moving into a clinical trial to treat pain due to malignancy.
Gene_expression (expressing) of NP2 associated with pain and malignant neoplastic disease
15) Confidence 0.25 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.01 Pain Relevance 0.10
Phase 1/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia.
Gene_expression (transfer) of vascular endothelial growth factor 2 gene associated with coronary artery disease and ischemia
16) Confidence 0.24 Published 2002 Journal Circulation Section Title Doc Link 11980678 Disease Relevance 0.10 Pain Relevance 0.13
The possible sources of the terminals and fibres containing ENK, NPY, NT, SS, and SP include the spinal cord and supraspinal areas, whereas the source of these structures with OXY and NP2 is most likely supraspinal.
Gene_expression (source) of NP2 in spinal cord associated with spinal cord
17) Confidence 0.24 Published 1987 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 3319110 Disease Relevance 0.06 Pain Relevance 0.37
There was no significant difference in the quantity of all se detected in NP1 and NP2 patients groups.
Gene_expression (groups) of NP2
18) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2832699 Disease Relevance 0.57 Pain Relevance 0.06
As mentioned above, VEGF165 is present at higher levels in sera, synovial fluid, and in the inflamed synovial tissues of RA patients than in those of osteoarthritis patients [13, 14].
Gene_expression (present) of VEGF165 in synovial fluid associated with rheumatoid arthritis and osteoarthritis
19) Confidence 0.01 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2638142 Disease Relevance 1.11 Pain Relevance 0.33
The expression patterns of the individual semaphorins are best characterized in the nervous system, particularly during development, where most, or perhaps all, semaphorins are widely expressed in the nervous system by neuronal and non-neuronal cells (reviewed in [17]; see Table 1 for details of the expression and functions of all members of the family and associated references).
Gene_expression (expressed) of semaphorins in nervous system
20) Confidence 0.01 Published 2006 Journal Genome Biol Section Body Doc Link PMC1557745 Disease Relevance 0.08 Pain Relevance 0

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