INT3637

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Context Info
Confidence 0.70
First Reported 1976
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 33
Total Number 34
Disease Relevance 2.13
Pain Relevance 10.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
nucleus 4
median eminence 4
thyroid 2
brain 2
pituitary 2
Trh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 5 100.00 Very High Very High Very High
Catecholamine 5 100.00 Very High Very High Very High
vagus nerve 1 99.92 Very High Very High Very High
Morphine 29 99.82 Very High Very High Very High
fluoxetine 6 99.72 Very High Very High Very High
Enkephalin 18 99.66 Very High Very High Very High
opiate 22 99.64 Very High Very High Very High
Opioid 8 99.64 Very High Very High Very High
narcan 13 99.52 Very High Very High Very High
antagonist 20 99.22 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 11 99.74 Very High Very High Very High
Lymphatic System Cancer 1 98.80 Very High Very High Very High
Dyskinesias 34 98.48 Very High Very High Very High
Functional Bowel Disorder 1 96.56 Very High Very High Very High
Headache 2 86.84 High High
Shock 2 79.52 Quite High
Disease 22 79.44 Quite High
Sprains And Strains 2 76.40 Quite High
Cluster Headache 2 75.00 Quite High
Ulcers 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of morphine and leucine enkephalin on basal and K+-induced TRH release by superfused mediobasal hypothalami in rats was investigated in an oxygenated modified Locke medium at 37 degrees C during 10 min.
Positive_regulation (induced) of Localization (release) of TRH associated with enkephalin and morphine
1) Confidence 0.70 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6412152 Disease Relevance 0 Pain Relevance 0.76
Opiate inhibition of K+-induced TRH release from superfused mediobasal hypothalami in rats.
Positive_regulation (induced) of Localization (release) of TRH associated with opiate
2) Confidence 0.70 Published 1983 Journal Neuroendocrinology Section Title Doc Link 6412152 Disease Relevance 0 Pain Relevance 0.88
Effects of morphine on cold-induced TRH release from the median eminence of unanesthetized rats.
Positive_regulation (induced) of Localization (release) of TRH in median eminence associated with narcan and morphine
3) Confidence 0.70 Published 1986 Journal Life Sci. Section Title Doc Link 3079851 Disease Relevance 0 Pain Relevance 0.66
The effect of morphine perfusion into the median eminence on cold-induced TRH secretion was studied in unanesthetized rats by push-pull cannulation.
Positive_regulation (induced) of Localization (secretion) of TRH in median eminence associated with morphine
4) Confidence 0.70 Published 1986 Journal Life Sci. Section Abstract Doc Link 3079851 Disease Relevance 0 Pain Relevance 0.55
Thus, as the encoding and synthesis of the peptide happens fully within the striatum, it seems likely that the effects of TRH in response to LIDs did not rely on the regulation of peripheral thyroid hormones, which would require release of TRH into the portal system.
Positive_regulation (require) of Localization (release) of TRH in thyroid associated with dyskinesias
5) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.88 Pain Relevance 0.13
Potassium and ouabain, a Na+/K+-ATPase inhibitor, stimulated TRH and C(HP) secretion in a graded fashion, but the magnitudes of C(HP) secretory responses were less than those of TRH.
Positive_regulation (stimulated) of Localization (secretion) of TRH
6) Confidence 0.70 Published 1987 Journal Endocrinology Section Abstract Doc Link 3100287 Disease Relevance 0 Pain Relevance 0.07
The calcium ionophore A23187 (1 mumol/l) stimulated TRH release to 340% of basal release.
Positive_regulation (stimulated) of Localization (release) of TRH
7) Confidence 0.70 Published 1987 Journal J. Endocrinol. Section Abstract Doc Link 3125299 Disease Relevance 0 Pain Relevance 0.17
Superfusion with norepinephrine (NE) (10(-10), 10(-8), 10(-6) M) induced a rapid and dose-dependent rise of TRH release; epinephrine (10(-8) M) induced an effect similar to that of NE 10(-8) M.
Positive_regulation (induced) of Localization (release) of TRH
8) Confidence 0.70 Published 1985 Journal Endocrinology Section Abstract Doc Link 2986944 Disease Relevance 0 Pain Relevance 0.21
Phentolamine (10(-7) M), an alpha-adrenergic antagonist, completely blocked the NE (10(-8) M)-induced release of TRH, which was not modified by the beta-adrenergic antagonist propranolol (10(-7) M).
Positive_regulation (induced) of Localization (release) of TRH associated with antagonist
9) Confidence 0.70 Published 1985 Journal Endocrinology Section Abstract Doc Link 2986944 Disease Relevance 0 Pain Relevance 0.29
The NE-induced release of TRH was completely suppressed by prazosin (10(-7) M), whereas yohimbine had no effect.
Positive_regulation (induced) of Localization (release) of TRH
10) Confidence 0.70 Published 1985 Journal Endocrinology Section Abstract Doc Link 2986944 Disease Relevance 0 Pain Relevance 0.32
From these findings it is concluded that the treatment of opioid peptide antisera stimulates TRH and TSH secretion in rats.
Positive_regulation (stimulates) of Localization (secretion) of TRH associated with opioid
11) Confidence 0.69 Published 1993 Journal Horm. Res. Section Abstract Doc Link 8406344 Disease Relevance 0 Pain Relevance 0.47
Endogenous 5-HT and TRH release from slices of lumbar cord was enhanced by high potassium. 7. p-Chloroamphetamine and fenfluramine increased 5-HT release but reduced or had no effect on TRH release.
Positive_regulation (enhanced) of Localization (release) of TRH
12) Confidence 0.69 Published 1982 Journal Comp. Biochem. Physiol. C, Comp. Pharmacol. Section Abstract Doc Link 6183051 Disease Relevance 0 Pain Relevance 0.62
CPHNA at a concentration of 10(-4) M increased both the basal and potassium stimulated recovery of TRH released from hypothalamic slices by approximately two-fold.
Positive_regulation (increased) of Localization (released) of TRH
13) Confidence 0.63 Published 1989 Journal Neuropeptides Section Abstract Doc Link 2575716 Disease Relevance 0 Pain Relevance 0.08
TRH only tended to be higher (p = 0.05) under 16 h L:8 h D than under 8 h L:16 h D, but morphine infusion induced a rapid and highly significant (p less than 0.01) increase in TRH secretion.
Positive_regulation (induced) of Localization (secretion) of TRH associated with morphine
14) Confidence 0.62 Published 1987 Journal Neuroendocrinology Section Abstract Doc Link 3122066 Disease Relevance 0 Pain Relevance 0.41
Vagal stimulation induced by TRH increases duodenal bicarbonate secretion by the release of VIP and, in part, by activation of a muscarinic pathway but not by pituitary, adrenal, and noradrenergic pathways or endogenous opiates and prostaglandins.
Neg (not) Positive_regulation (activation) of Localization (secretion) of TRH in pituitary associated with opiate
15) Confidence 0.50 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2531983 Disease Relevance 0 Pain Relevance 0.33
In contrast, depolarizing concentrations of K+ (50 mM) were found to cause the immediate release of TRH, but not VIP, from the same perifusion.
Positive_regulation (cause) of Localization (release) of TRH
16) Confidence 0.50 Published 1987 Journal Life Sci. Section Abstract Doc Link 3102870 Disease Relevance 0 Pain Relevance 0.54
Thyrotropin-releasing hormone increases serotonin (5-HT) secretion into the stomach.
Positive_regulation (increases) of Localization (secretion) of Thyrotropin-releasing hormone in stomach associated with serotonin
17) Confidence 0.50 Published 1996 Journal Psychosom Med Section Abstract Doc Link 8948002 Disease Relevance 0.15 Pain Relevance 0.22
Thyrotropin-releasing hormone (TRH) injected either IP (10 mg/kg) or intraventricularly (10 mug/rat) antagonized the pentobarbital-induced secretion of prolactin (PRL).
Positive_regulation (pentobarbital-induced) of Localization (secretion) of Thyrotropin-releasing hormone
18) Confidence 0.49 Published 1976 Journal Eur. J. Pharmacol. Section Abstract Doc Link 819277 Disease Relevance 0 Pain Relevance 0.15
Holtzman rats released significantly more prolactin following TRH than did Long-Evans rats when the RIA was used to measure prolactin.
Positive_regulation (following) of Localization (released) of TRH
19) Confidence 0.49 Published 1991 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 1908099 Disease Relevance 0.18 Pain Relevance 0.09
Thyroidectomy induces Fos-like immunoreactivity within thyrotropin-releasing hormone-expressing neurons located in the paraventricular nucleus of the adult rat hypothalamus.
Positive_regulation (induces) of Localization (releasing) of thyrotropin-releasing hormone in nucleus
20) Confidence 0.49 Published 1991 Journal Endocrinology Section Title Doc Link 1954900 Disease Relevance 0 Pain Relevance 0.08

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