INT36382

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Context Info
Confidence 0.36
First Reported 1988
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 4.13
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (FUT4) Golgi apparatus (FUT4) carbohydrate metabolic process (FUT4)
Anatomy Link Frequency
epithelial cells 1
neutrophils 1
FUT4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 25 93.24 High High
peptic ulcer disease 25 92.80 High High
Chronic pancreatitis 4 69.52 Quite High
Inflammation 146 33.88 Quite Low
nud 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 791 100.00 Very High Very High Very High
Gastritis 96 93.84 High High
INFLAMMATION 159 92.84 High High
Ulcers 29 92.80 High High
Disease 62 91.76 High High
Malignant Neoplastic Disease 14 91.12 High High
Infection 257 90.48 High High
Stomach Disease 12 88.68 High High
Pancreatic Cancer 8 86.48 High High
Adhesions 13 81.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A strong correlation was found between bacterial binding to sdiLex and HA titers resulting from sialidase treatment (correlation of rank = 0.547; p < 0.001) (Figure 2A).
Lex Binding (binding) of
1) Confidence 0.36 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1626103 Disease Relevance 0.14 Pain Relevance 0
The present study demonstrates an example of how TCST-mediated regulation and phase variation combine to regulate the transcription of sabA, and the subsequent ability of H. pylori to bind sialyl-Lex displayed on gastric epithelial cells.
Lex Binding (bind) of in epithelial cells
2) Confidence 0.35 Published 2008 Journal Microbiology Section Body Doc Link PMC2715451 Disease Relevance 0.22 Pain Relevance 0.04
Monoclonal antibodies anti-SSEA-1 and AH6 recognize "simple" Lex and Ley epitopes, respectively, regardless of the length of the carrier carbohydrate.
anti-SSEA-1 Binding (recognize) of
3) Confidence 0.29 Published 1988 Journal Cancer Res. Section Abstract Doc Link 3335015 Disease Relevance 0.45 Pain Relevance 0.07
-shaped” binding mode) (seven of 39 isolates, or approximately 20%); (3) isolates that bind sdiLex and sLn(14) the best, whereas binding to sLea is lower (i.e., isolates with a “V-shaped” binding mode [similar to the binding mode of strain 17874; Figure 3]) (three of 39 isolates, or approximately 10%); (4) isolates that bind sLex but show only modest binding to sLea and sLn(14) (seven of 39 isolates, or approximately 20%); and (5) isolates generally modest in binding (in the interval 1%–5%) for all sialyl conjugates (ten of 39 isolates, or approximately 20%).
sLex Binding (bind) of associated with sprains and strains
4) Confidence 0.01 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1626103 Disease Relevance 0.25 Pain Relevance 0
However, the prevalence of sialic acid binding may have been underestimated among clinical isolates since: (1) H. pylori exhibits on/off phase variation in sialyl binding, and sia-HA could be rapidly lost during passage in culture [15]; (2) almost half of the strains that bound sLex did not cause sia-HA (Figure 2), which suggests that many strains require complex sialylated glycans for binding (such structures are limited on erythrocytes, but are present both in gastric epithelium and on neutrophils [45]); and (3) culture conditions have been shown to influence binding specificity and affinity for sialylated glycoconjugates [34].
sLex Binding (bound) of in neutrophils associated with sprains and strains
5) Confidence 0.01 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1626103 Disease Relevance 0.81 Pain Relevance 0
This figure is similar to the prevalence of sLex binding among clinical isolates [15].
sLex Binding (binding) of
6) Confidence 0.01 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1626103 Disease Relevance 0.34 Pain Relevance 0.05
This is a distinct difference compared to previous results, where merely half of sLex-binding strains also bound sLea [15].
sLex Binding (bound) of associated with sprains and strains
7) Confidence 0.01 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1626103 Disease Relevance 0.18 Pain Relevance 0
H. pylori has been suggested to exploit mechanisms of “selectin mimicry” to “home in” on inflamed gastric tissue by binding to epithelial sLex and sLea.
sLex Binding (binding) of
8) Confidence 0.01 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1626103 Disease Relevance 0.85 Pain Relevance 0.18
For the series of 99 clinical isolates, HA titers were compared with prevalence of sLex binding.
sLex Binding (binding) of
9) Confidence 0.01 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1626103 Disease Relevance 0.08 Pain Relevance 0
Interestingly, clinical isolates demonstrated several distinct binding modes for sialylated glycans, although most isolates bound best to sLex.
sLex Binding (bound) of
10) Confidence 0.01 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1626103 Disease Relevance 0.18 Pain Relevance 0
The results revealed that periodate-treated BSA did not inhibit sLex binding, whereas the untreated BSA showed strong inhibition.
sLex Binding (binding) of
11) Confidence 0.01 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1626103 Disease Relevance 0.09 Pain Relevance 0
H. pylori transformants were analyzed for binding to 125I-labeled sLex conjugate and for expression of SabA using anti-SabA antibodies, as described above.
sLex Spec (analyzed) Binding (binding) of
12) Confidence 0.01 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1626103 Disease Relevance 0.14 Pain Relevance 0
This is also supported by the 10-fold increased binding affinity for sLex, 1 × 109 M?
sLex Binding (affinity) of
13) Confidence 0.01 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1626103 Disease Relevance 0.19 Pain Relevance 0
Furthermore, all strains demonstrated increased binding for sLex, sdiLex, and sLea compared to sialylated structures lacking fucose constituents.
sLex Binding (binding) of associated with sprains and strains
14) Confidence 0.01 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1626103 Disease Relevance 0.22 Pain Relevance 0

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