INT36389

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Context Info
Confidence 0.45
First Reported 1988
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 20
Disease Relevance 7.22
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

immune system process (AHR) cell morphogenesis (AHR) DNA binding (AHR)
response to stress (AHR) cytoplasm (AHR) signal transducer activity (AHR)
Anatomy Link Frequency
respiratory 2
macrophages 1
pituitary 1
AHR (Homo sapiens)
Pain Link Frequency Relevance Heat
Analgesic 8 95.68 Very High Very High Very High
aspirin 29 94.68 High High
cINOD 24 88.96 High High
Inflammation 35 77.56 Quite High
antagonist 14 75.00 Quite High
Chronic pancreatitis 4 69.52 Quite High
cytokine 8 69.00 Quite High
alcohol 13 5.00 Very Low Very Low Very Low
beta blocker 8 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 164 99.80 Very High Very High Very High
Atherosclerosis 8 98.96 Very High Very High Very High
Rhinitis 38 95.64 Very High Very High Very High
Hepatocellular Cancer 6 95.48 Very High Very High Very High
Apoptosis 110 95.24 Very High Very High Very High
Adhesions 2 90.96 High High
Malignant Neoplastic Disease 2 90.48 High High
Cancer 65 88.52 High High
Stress 175 86.32 High High
Pancreatic Cancer 10 85.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The transcription of the CYP1 family of genes is regulated by the interaction of TCDD-activated AhR with the xenobiotic-responsive element present in the promoter regions of these genes.
AhR Binding (interaction) of
1) Confidence 0.45 Published 2004 Journal Cancer Res. Section Abstract Doc Link 14729655 Disease Relevance 0.14 Pain Relevance 0.32
As shown by electrophoretic mobility shift assay, SAL completely blocked the binding of TCDD-activated AhR to the xenobiotic responsive element.
AhR Binding (binding) of
2) Confidence 0.45 Published 2004 Journal Cancer Res. Section Abstract Doc Link 14729655 Disease Relevance 0.12 Pain Relevance 0.31
Sulindac bound to the AhR, as measured by ligand-binding assay, and induced the binding of the AhR with the xenobiotic-responsive element present in the promoter region of the CYP1A1 gene.
AhR Binding (bound) of
3) Confidence 0.38 Published 2006 Journal Carcinogenesis Section Abstract Doc Link 16531450 Disease Relevance 0.12 Pain Relevance 0.16
Unlike evidence from experimental studies in which the affinity to aryl hydrocarbon receptor (AhR) was important to induce atherosclerosis (Hennig et al. 2002; Stegeman et al. 1995; Toborek et al. 1995), the strengths of association of each POP belonging to the category of PCDDs or PCDFs did not appear to be correlated with the toxic equivalent factors (TEFs) of each POP.
AhR Binding (affinity) of associated with atherosclerosis
4) Confidence 0.37 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1940073 Disease Relevance 0.60 Pain Relevance 0
The concept of TEFs, a measure of the ability to bind to the AhR, was developed to facilitate risk assessment and regulatory control of exposure to complex PCDD, PCDF, and PCB mixtures (Van den Berg et al. 2006).
AhR Binding (bind) of
5) Confidence 0.36 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1940073 Disease Relevance 0.42 Pain Relevance 0
Also, SAL substantially blocked the binding of TCDD to the cytosolic AhR.
AhR Binding (binding) of
6) Confidence 0.33 Published 2004 Journal Cancer Res. Section Abstract Doc Link 14729655 Disease Relevance 0.07 Pain Relevance 0.31
The upregulation of CYP1A1 and CYP1B1 expression by extract and purified cycloartanes cannot be explained by AhR binding.
AhR Binding (binding) of
7) Confidence 0.33 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.26 Pain Relevance 0
These findings are in contradiction with previous experiments showing weak AhR binding and transactivation activity of black cohosh extracts.
AhR Binding (binding) of
8) Confidence 0.33 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.45 Pain Relevance 0
Sulindac bound to the AhR, as measured by ligand-binding assay, and induced the binding of the AhR with the xenobiotic-responsive element present in the promoter region of the CYP1A1 gene.
AhR Binding (binding) of
9) Confidence 0.30 Published 2006 Journal Carcinogenesis Section Abstract Doc Link 16531450 Disease Relevance 0.07 Pain Relevance 0.09
The AhR, upon binding of a ligand, forms a heterodimeric complex with ARNT (aryl hydrocarbon receptor nuclear translocator) which induces transactivation of the CYPs and other target genes via binding to xenobiotic response elements (XREs) in their promoter regions [63].
AhR Binding (binding) of
10) Confidence 0.25 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0 Pain Relevance 0
Dioxin-like chemicals are thought to accomplish this through binding to the aryl hydrocarbon receptor (AhR), which induces uridine diphosphate glucuronosyltransferase enzymes, leading to increased glucuronidation and excretion of T4 (Fisher et al. 2006; van Birgelen et al. 1995).
AhR Binding (binding) of
11) Confidence 0.17 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1940071 Disease Relevance 0 Pain Relevance 0
Ortho-substituted PCBs, which do not bind to the AhR, disrupt the HPT axis through other mechanisms which may include increased glucuronidation through non AhR pathways, displacement of T4 from the binding protein transthyretin, and direct effects on TSH release from the pituitary (Brouwer et al. 1990; Khan et al. 2002; van Birgelen et al. 1992, 1995).
AhR Neg (not) Binding (bind) of in pituitary
12) Confidence 0.17 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1940071 Disease Relevance 0 Pain Relevance 0
The other represents genes with promoter motifs for GA binding protein transcription factor (GABP)/nuclear respiratory factor 2 (NRF2), member of the E-26 (ETS) oncogene family (ELK1) and aryl hydrocarbon receptor (AhR).
aryl hydrocarbon receptor Binding (genes) of in respiratory
13) Confidence 0.13 Published 2010 Journal BMC Med Section Body Doc Link PMC2955589 Disease Relevance 0.35 Pain Relevance 0
The other represents genes with promoter motifs for GA binding protein transcription factor (GABP)/nuclear respiratory factor 2 (NRF2), member of the E-26 (ETS) oncogene family (ELK1) and aryl hydrocarbon receptor (AhR).
AhR Binding (genes) of in respiratory
14) Confidence 0.13 Published 2010 Journal BMC Med Section Body Doc Link PMC2955589 Disease Relevance 0.35 Pain Relevance 0
Evidence suggests that this location is associated with AHR and the severity of asthma.9-11 Genetic analyses have implicated the human IL-13 gene in the development of atopy and asthma.
AHR Binding (associated) of associated with asthma and rhinitis
15) Confidence 0.13 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.36 Pain Relevance 0.13
This SNP was also reported to be associated with methacholine AHR and asthma development in a childhood asthma cohort based on a Korean population.21 Specifically, IL-13 110AA was associated with increased total IgE levels and asthma development in children.
AHR Binding (associated) of associated with asthma
16) Confidence 0.12 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846737 Disease Relevance 1.31 Pain Relevance 0.07
Phytochemicals may act as ligands for AHR [34].
AHR Binding (ligands) of
17) Confidence 0.12 Published 2010 Journal BMC Med Section Body Doc Link PMC2955589 Disease Relevance 0.47 Pain Relevance 0
Owing to the limitations of our analytical method, we did not study non-ortho PCBs that have a greater affinity for the Ah receptor than do mono-ortho PCBs as a result of their “coplanar” molecular structure, which may have strengthened our hypothesis.
Ah receptor Binding (affinity) of
18) Confidence 0.08 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247607 Disease Relevance 0.45 Pain Relevance 0
This suggests that an unaffected AHR/ARNT transcription factor complex that is likely to occur in the IRGM wild-type gene promoter, may decrease innate immune responses mediated by macrophages.
AHR Binding (complex) of in macrophages
19) Confidence 0.04 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2735778 Disease Relevance 0.23 Pain Relevance 0
Monoclonal antibodies anti-SSEA-1 and AH6 recognize "simple" Lex and Ley epitopes, respectively, regardless of the length of the carrier carbohydrate.
AH6 Binding (recognize) of
20) Confidence 0.02 Published 1988 Journal Cancer Res. Section Abstract Doc Link 3335015 Disease Relevance 0.45 Pain Relevance 0.07

General Comments

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