INT36396

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Context Info
Confidence 0.44
First Reported 1988
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 4.57
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Psen2) endoplasmic reticulum (Psen2) embryo development (Psen2)
protein complex (Psen2) cytosol (Psen2) peptidase activity (Psen2)
Anatomy Link Frequency
Mouse 2
leukocytes 1
MCF-7 1
Psen2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 4 99.90 Very High Very High Very High
anesthesia 7 96.96 Very High Very High Very High
Inflammatory response 18 93.72 High High
glial activation 2 65.72 Quite High
cINOD 38 46.40 Quite Low
ischemia 2 35.00 Quite Low
cytokine 13 7.68 Low Low
Inflammation 46 5.00 Very Low Very Low Very Low
Hippocampus 10 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 211 99.76 Very High Very High Very High
INFLAMMATION 70 99.70 Very High Very High Very High
Targeted Disruption 79 99.20 Very High Very High Very High
Neurodegenerative Disease 7 98.96 Very High Very High Very High
Cognitive Disorder 35 98.06 Very High Very High Very High
Alzheimer's Dementia 59 97.34 Very High Very High Very High
Cancer 38 92.80 High High
Death 13 84.68 Quite High
Breast Cancer 21 75.52 Quite High
Disease Progression 3 71.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Presenilin-2 Mutation Causes Early Amyloid Accumulation and Memory Impairment in a Transgenic Mouse Model of Alzheimer's Disease

In order to clarify the pathophysiological role of presenilin-2 (PS2) carrying the Volga German Kindred mutation (N141I) in a conventional mouse model of Alzheimer's disease (AD) expressing amyloid precursor protein (APP) with the Swedish mutation (Tg2576 line), we generated a double transgenic mouse (PS2Tg2576) by crossbreeding the PS2 mutant with Tg2576 mice.

Positive_regulation (role) of presenilin-2 in Mouse associated with targeted disruption, cognitive disorder, alzheimer's dementia and disease
1) Confidence 0.44 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Title Doc Link PMC3018662 Disease Relevance 0.93 Pain Relevance 0
Presenilin-2 Mutation Causes Early Amyloid Accumulation and Memory Impairment in a Transgenic Mouse Model of Alzheimer's Disease

In order to clarify the pathophysiological role of presenilin-2 (PS2) carrying the Volga German Kindred mutation (N141I) in a conventional mouse model of Alzheimer's disease (AD) expressing amyloid precursor protein (APP) with the Swedish mutation (Tg2576 line), we generated a double transgenic mouse (PS2Tg2576) by crossbreeding the PS2 mutant with Tg2576 mice.

Positive_regulation (role) of PS2 in Mouse associated with targeted disruption, cognitive disorder, alzheimer's dementia and disease
2) Confidence 0.44 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Title Doc Link PMC3018662 Disease Relevance 0.93 Pain Relevance 0
However, complementation of FAD-associated variants of PS2 selectively elevated A?
Positive_regulation (variants) of PS2 associated with disease
3) Confidence 0.44 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.91 Pain Relevance 0
Beginning at 6 months of age, and coinciding with the neurodegenerative process, leukocytes and inflammatory mediators are elevated in serum of mutant PS1/PS2 conditional double knockout (PS cDKO) mice (Jiang et al., 2009).
Positive_regulation (elevated) of PS2 in leukocytes associated with targeted disruption, inflammatory mediators and neurodegenerative disease
4) Confidence 0.41 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 1.20 Pain Relevance 0.18
While the basal level of pS2 mRNA is elevated in untreated MCF-7CLU cells relative to the parental cell line, the estrogen induced expression of pS2 mRNA, and the responsiveness to tamoxifen is essentially equivalent in the parental and MCF-7CLU cell lines, indicating that clusterin over expression has not significantly altered the ability of the estrogen receptor to transactivate known target genes.
Positive_regulation (elevated) of pS2 mRNA
5) Confidence 0.20 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.05 Pain Relevance 0
siRNA against NCoA6(ASC-2) was used in MCF-7 cells to demonstrate the E2-dependent induction of pS2 gene expression [Ju et al., 2006].


Positive_regulation (induction) of pS2 in MCF-7
6) Confidence 0.16 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.48 Pain Relevance 0
After adjusting for patient, anesthesia, and surgery-related variables by multiple logistic regression, the relative odds of having an intraoperative or postoperative major complication were increased for patients classified PS2, PS3 and PS4 & 5 as compared to PS1.
Positive_regulation (increased) of PS2 associated with anesthesia
7) Confidence 0.09 Published 1988 Journal J Clin Epidemiol Section Abstract Doc Link 3335873 Disease Relevance 0.07 Pain Relevance 0.22

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