INT36400

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Context Info
Confidence 0.62
First Reported 1988
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.73
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SCN10A) transmembrane transport (SCN10A)
Anatomy Link Frequency
SNS 2
outflow 1
SNS 1
pituitary 1
skin 1
SCN10A (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 12 100.00 Very High Very High Very High
agonist 6 100.00 Very High Very High Very High
Congenital analgesia 1 98.56 Very High Very High Very High
Catecholamine 11 98.48 Very High Very High Very High
Spontaneous pain 1 96.20 Very High Very High Very High
Demyelination 1 95.40 Very High Very High Very High
guanethidine 1 94.96 High High
Inflammation 1 94.80 High High
allodynia 1 80.80 Quite High
Hyperalgesia 1 80.24 Quite High
Disease Link Frequency Relevance Heat
Pain 5 98.56 Very High Very High Very High
Hypersensitivity 1 98.12 Very High Very High Very High
Overweight 12 97.74 Very High Very High Very High
Demyelinating Disease 1 95.40 Very High Very High Very High
INFLAMMATION 1 94.80 High High
Eating Disorder 4 94.08 High High
Stress 63 91.96 High High
Syndrome 2 91.24 High High
Obesity 32 85.08 High High
Neuropathic Pain 1 80.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The TEF and SNS response to an 800-kcal high-carbohydrate liquid meal (85% carbohydrate, 15% protein) was studied in eight healthy male subjects (27 +/- 6 yr) on two separate occasions with the subjects wearing either a clonidine or placebo skin patch for 48 h prior to study.
Regulation (response) of SNS in skin associated with clonidine
1) Confidence 0.62 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 3337274 Disease Relevance 0 Pain Relevance 0.48
In the present study we chose instead to evaluate the effect of clonidine, a centrally acting alpha 2-adrenergic receptor agonist that inhibits SNS outflow, on TEF and SNS activity as reflected by both plasma catecholamines and norepinephrine (NE) kinetics.
Regulation (effect) of SNS in SNS associated with catecholamine, agonist and clonidine
2) Confidence 0.45 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 3337274 Disease Relevance 0 Pain Relevance 0.47
Likely, the context of presentation affects SNS activation of affective pictures.
Regulation (affects) of SNS
3) Confidence 0.39 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2577930 Disease Relevance 0.29 Pain Relevance 0
The effects of SNS inhibition on sexual responses in the female rat were examined in 3 studies using clonidine, an alpha(2)-adrenergic agonist; guanethidine, a postganglionic noradrenergic blocker; and naphazoline, an alpha(2)-adrenoreceptor agonist, to inhibit sympathetic outflow.
Regulation (effects) of SNS in outflow associated with guanethidine, agonist and clonidine
4) Confidence 0.39 Published 2000 Journal Am. J. Cardiol. Section Abstract Doc Link 10899275 Disease Relevance 0 Pain Relevance 0.31
Our studies suggest that the best target for SNS/PN3 blocking agents is likely to be chronic local hypersensitivity.
Regulation (target) of SNS/PN3 associated with hypersensitivity
5) Confidence 0.39 Published 2000 Journal Pain Section Abstract Doc Link 10692601 Disease Relevance 1.05 Pain Relevance 0.63
With respect to capsinoids' positive effect on the sympathetic nervous system (SNS), this phenomenon has been demonstrated consistently in other human studies [2-4].
Regulation (effect) of SNS in SNS
6) Confidence 0.33 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2922296 Disease Relevance 0.21 Pain Relevance 0
In overweight subjects, a hypoactive hypothalamic┬ľpituitary┬ľadrenal-axis, not knowing whether it is cause or consequence of a dysregulated SNS, may contribute to greater hunger and over-consumption.
Spec (whether) Regulation (dysregulated) of SNS in pituitary associated with overweight
7) Confidence 0.22 Published 2007 Journal Eur J Appl Physiol Section Body Doc Link PMC2225999 Disease Relevance 0.97 Pain Relevance 0.06
An inverse relationship of SNS activity and body fat emphasize the importance of the SNS in food intake, suggesting a role of ?
Regulation (importance) of SNS in SNS
8) Confidence 0.22 Published 2007 Journal Eur J Appl Physiol Section Body Doc Link PMC2225999 Disease Relevance 0.20 Pain Relevance 0.03

General Comments

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