INT36405

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Context Info
Confidence 0.66
First Reported 1988
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 26
Total Number 27
Disease Relevance 24.50
Pain Relevance 7.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Insr) endosome (Insr) plasma membrane (Insr)
nucleus (Insr) kinase activity (Insr)
Anatomy Link Frequency
macrophages 4
striatum 3
monocytes 2
plasma 1
skeletal muscle 1
Insr (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 230 99.88 Very High Very High Very High
Inflammation 516 99.84 Very High Very High Very High
antagonist 61 99.72 Very High Very High Very High
agonist 62 99.12 Very High Very High Very High
Kappa opioid receptor 250 98.84 Very High Very High Very High
Dynorphin 245 98.66 Very High Very High Very High
Nerve growth factor 56 98.26 Very High Very High Very High
medulla 2 97.48 Very High Very High Very High
Osteoarthritis 30 97.08 Very High Very High Very High
midbrain 2 95.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 1172 100.00 Very High Very High Very High
Bacterial Meningitis 33 100.00 Very High Very High Very High
Convulsion 14 99.92 Very High Very High Very High
INFLAMMATION 547 99.84 Very High Very High Very High
Pneumococcal Infection 54 99.84 Very High Very High Very High
Insulin Resistance 337 99.62 Very High Very High Very High
Hypersensitivity 159 99.00 Very High Very High Very High
Stress 255 98.76 Very High Very High Very High
Pneumonia 36 97.66 Very High Very High Very High
Osteoarthritis 30 97.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the hypothalamus, IR Leu-E levels were increased by 85% 45 min after a convulsion.
Positive_regulation (increased) of IR Leu-E in hypothalamus associated with convulsion
1) Confidence 0.66 Published 1988 Journal Epilepsia Section Abstract Doc Link 3338427 Disease Relevance 0.78 Pain Relevance 0.24
IR Leu-E was also increased in the striatum (176% of preconvulsive state), cortex (121%), medulla oblongata + pons (132%), hypothalamus (180%), and midbrain (159%) 48 h after a convulsion.
Positive_regulation (increased) of IR Leu-E in striatum associated with medulla, convulsion and midbrain
2) Confidence 0.66 Published 1988 Journal Epilepsia Section Abstract Doc Link 3338427 Disease Relevance 0.86 Pain Relevance 0.25
To determine the role of insulin action in macrophages and monocytes in obesity-associated insulin resistance, we conditionally inactivated the insulin receptor (IR) gene in myeloid lineage cells in mice (IR?
Positive_regulation (inactivated) of insulin receptor in monocytes associated with obesity and insulin resistance
3) Confidence 0.29 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2865520 Disease Relevance 1.31 Pain Relevance 0.17
To determine the role of insulin action in macrophages and monocytes in obesity-associated insulin resistance, we conditionally inactivated the insulin receptor (IR) gene in myeloid lineage cells in mice (IR?
Positive_regulation (inactivated) of IR in monocytes associated with obesity and insulin resistance
4) Confidence 0.29 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2865520 Disease Relevance 1.32 Pain Relevance 0.17
However, in line with the reduced mRNA expression of macrophage marker genes, immunohistochemical analysis of infiltrating, activated macrophages demonstrated a striking reduction of Mac-2-positive cells in WAT of diet-induced obese IR?
Positive_regulation (induced) of IR in macrophages associated with obesity
5) Confidence 0.27 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.07 Pain Relevance 0
Importantly, adiponectin expression was significantly increased in adipocytes from IR?
Positive_regulation (increased) of IR in adipocytes associated with obesity
6) Confidence 0.27 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.13 Pain Relevance 0.21
Moreover, white adipose tissue mass, body fat content, circulating leptin concentrations as an indirect measure of fat mass and serum FFA were significantly elevated in mice exposed to HFD, but indistinguishable between control- and IR?
Positive_regulation (elevated) of IR in fat associated with obesity
7) Confidence 0.27 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.91 Pain Relevance 0.03
In addition, insulin-stimulated glucose disposal in skeletal muscle was significantly increased in IR?
Positive_regulation (increased) of IR in skeletal muscle
8) Confidence 0.27 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 0.85 Pain Relevance 0.08
Another question is why reduced macrophage accumulation in obese IR?
Positive_regulation (accumulation) of IR in macrophage associated with obesity
9) Confidence 0.25 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2865520 Disease Relevance 1.25 Pain Relevance 0.04
Furthermore, stable transfection of STAT1 in the radiosensitive SCC61 cell line led to the formation of an IR- and IFN-resistant phenotype, thus confirming that constitutive overexpression of STAT1 conferred resistance to genotoxic stress.
Positive_regulation (formation) of IR associated with dna damage
10) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688034 Disease Relevance 0.70 Pain Relevance 0
MA-induced increases in activator protein (AP)-1 DNA binding activity, Fos-related antigen immunoreactivity (FRA-IR), proenkephalin mRNA expression, and proenkephalin-like immunoreactivity were reduced consistently in the striatum of animals that were pretreated with ginsenosides.
Positive_regulation (increases) of FRA-IR in striatum
11) Confidence 0.10 Published 2005 Journal Behav. Brain Res. Section Abstract Doc Link 15680202 Disease Relevance 0 Pain Relevance 0.30
To determine the role of insulin action in macrophages and monocytes in obesity-associated insulin resistance, we conditionally inactivated the insulin receptor (IR) gene in myeloid lineage cells in mice (IR?
Positive_regulation (inactivated) of insulin receptor in macrophages associated with obesity and insulin resistance
12) Confidence 0.10 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2865520 Disease Relevance 1.31 Pain Relevance 0.17
To determine the role of insulin action in macrophages and monocytes in obesity-associated insulin resistance, we conditionally inactivated the insulin receptor (IR) gene in myeloid lineage cells in mice (IR?
Positive_regulation (inactivated) of IR in macrophages associated with obesity and insulin resistance
13) Confidence 0.10 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2865520 Disease Relevance 1.32 Pain Relevance 0.17
Our results suggest that the stimulation of A2A receptors by ginsenosides attenuates the changes in behavior and the increases in AP-1 DNA binding activity, FRA-IR, and proenkephalin gene expression in mouse striatum that are induced by MA.
Positive_regulation (increases) of FRA-IR in striatum
14) Confidence 0.08 Published 2005 Journal Behav. Brain Res. Section Abstract Doc Link 15680202 Disease Relevance 0 Pain Relevance 0.25
agonists reversed these pathological alterations by increasing insulin receptor binding, countering oxidative stress and ?
Positive_regulation (increasing) of insulin receptor associated with stress and agonist
15) Confidence 0.06 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912024 Disease Relevance 0.94 Pain Relevance 0.11
However, it is not likely that the numerous NPP1 catalytic site-independent mutants implicated as interfering with ligand-induced insulin receptor signaling directly affect mineralization.
Neg (not) Positive_regulation (induced) of insulin receptor
16) Confidence 0.05 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.60 Pain Relevance 0.03
NPP1, in a catalytic activity-independent manner, inhibits ligand-induced insulin receptor signaling [65], an effect that appears linked to NPP1 mutations associated with type II diabetes mellitus in some but not all ethnic groups studied [66, 67].
Positive_regulation (induced) of insulin receptor associated with diabetes mellitus
17) Confidence 0.05 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.92 Pain Relevance 0.07
In addition, the decrease in plasma adiponectin levels was correlated with the increases in plasma insulin and HOMA-IR.
Positive_regulation (increases) of HOMA-IR in plasma
18) Confidence 0.04 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 1.34 Pain Relevance 0.03
This compound is a potent activator of TrkA (200% the activity of NGF) and a partial activator of TrkC (80% the activity of NT-3), but does not appreciably stimulate TrkB or the insulin receptor.
Neg (not) Positive_regulation (stimulate) of insulin receptor associated with nerve growth factor
19) Confidence 0.02 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.32 Pain Relevance 0.39
In contrast, KORp-ir was not increased in BLA from mice that had been stereotaxically injected norBNI in the BLA (Fig. 4B,D).
Neg (not) Positive_regulation (increased) of KORp-ir associated with amygdala
20) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795205 Disease Relevance 0.05 Pain Relevance 0.64

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