INT36410

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Context Info
Confidence 0.58
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.00
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Rere) nucleus (Rere) DNA binding (Rere)
Rere (Mus musculus)
Rere - R6L (1)
Pain Link Frequency Relevance Heat
Enkephalin 7 99.76 Very High Very High Very High
Dynorphin 5 98.14 Very High Very High Very High
Opioid 2 97.46 Very High Very High Very High
Analgesic 10 96.48 Very High Very High Very High
Spinal cord 2 75.00 Quite High
Endogenous opioid 1 47.80 Quite Low
Potency 1 39.84 Quite Low
Antinociceptive 2 36.56 Quite Low
narcan 1 25.00 Low Low
ischemia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 8 93.36 High High
Targeted Disruption 1 79.64 Quite High
Apoptosis 1 77.04 Quite High
Frailty 5 75.76 Quite High
Contusions 1 63.28 Quite High
Rheumatoid Arthritis 20 5.00 Very Low Very Low Very Low
Body Weight 8 5.00 Very Low Very Low Very Low
Hypotension 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Anorexia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To understand the effect of the replacement of Tyr residue at position 1 in opioid peptides by 2,6-dimethyl-Tyr (Dmt) on the biological property, chiral (D or L) Dmt1 analogs of Leu-enkephalin (Enk) and Tyr-D-Arg-Phe-beta Ala-NH2 (YRFB) were synthesized and their enzymatic stabilities, in vitro bioactivities and receptor binding affinities compared with those of parent peptides.
Gene_expression (synthesized) of Arg associated with enkephalin and opioid
1) Confidence 0.58 Published 1999 Journal Chem. Pharm. Bull. Section Abstract Doc Link 10553648 Disease Relevance 0 Pain Relevance 0.53
Radioimmunoassay showed that dynorphin A(1-17) was regionally increased in wild-type injured versus sham-injured tissues, although levels of the prodynorphin processing product Arg(6)-Leu-enkephalin were unchanged.
Gene_expression (levels) of Arg (R6L) associated with dynorphin and enkephalin
2) Confidence 0.58 Published 2007 Journal Neuroscience Section Abstract Doc Link 17698296 Disease Relevance 1.00 Pain Relevance 0.37
The syntheses of Trp(Nps)-Arg-OMe.HCl (15) [Trp(Nps) = 2-[(o-nitrophenyl)sulfenyl]tryptophan], its three stereoisomers, and their corresponding cyclic analogues are reported.
Gene_expression (syntheses) of Arg
3) Confidence 0.09 Published 1988 Journal J. Med. Chem. Section Abstract Doc Link 3339602 Disease Relevance 0 Pain Relevance 0.23
His and Arg are semidispensable amino acids.
Gene_expression (His) of Arg
4) Confidence 0.04 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2836181 Disease Relevance 0 Pain Relevance 0
The syntheses of dipeptide derivatives of the general formula X-Trp(Nps)-OR (R = H or Me; X = Lys, Gly, Ala, Leu, Ser, Glu, His, Arg, Orn, Dpr, Gpr and Har) are described.
Gene_expression (syntheses) of Arg
5) Confidence 0.01 Published 1987 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 3610476 Disease Relevance 0 Pain Relevance 0.25

General Comments

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