INT36449

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Context Info
Confidence 0.59
First Reported 1986
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 74
Total Number 75
Disease Relevance 54.15
Pain Relevance 8.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (G6PD) small molecule metabolic process (G6PD) oxidoreductase activity (G6PD)
carbohydrate metabolic process (G6PD) lipid metabolic process (G6PD) cytoplasm (G6PD)
Anatomy Link Frequency
skin 3
erythrocyte 2
reticulocyte 2
corpus 1
Caco-2 1
G6PD (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 11 99.92 Very High Very High Very High
Arthritis 45 99.90 Very High Very High Very High
Inflammation 28 99.84 Very High Very High Very High
anesthesia 40 99.64 Very High Very High Very High
cINOD 38 99.46 Very High Very High Very High
Paracetamol 17 99.44 Very High Very High Very High
fibrosis 19 99.36 Very High Very High Very High
abdominal pain 28 98.88 Very High Very High Very High
Perioperative pain 4 98.64 Very High Very High Very High
Pain 58 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperlipidemia 2 99.92 Very High Very High Very High
Porphyria 1 99.92 Very High Very High Very High
Arthritis 49 99.90 Very High Very High Very High
Thalassemia 9 99.88 Very High Very High Very High
Hyperbilirubinemia 2 99.88 Very High Very High Very High
INFLAMMATION 39 99.84 Very High Very High Very High
Disease 120 99.82 Very High Very High Very High
Sickle Cell Anemia 86 99.82 Very High Very High Very High
Sickle Cell Trait 19 99.80 Very High Very High Very High
Hemolysis 104 99.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Organocopper compounds may cause prolonged hemolysis and methemoglobinemia through oxidative stress, especially among patients with G6PD deficiency.
Negative_regulation (deficiency) of G6PD associated with stress, hemolysis and methemoglobinemia
1) Confidence 0.59 Published 2004 Journal Vet Hum Toxicol Section Abstract Doc Link 15587250 Disease Relevance 0.96 Pain Relevance 0.11
Pre-existing glucose-6-phosphate dehydrogenase (G6PD) deficiency as well as copper-induced inhibition of G6PD activity was documented during hospitalization.
Negative_regulation (inhibition) of G6PD
2) Confidence 0.59 Published 2004 Journal Vet Hum Toxicol Section Abstract Doc Link 15587250 Disease Relevance 1.34 Pain Relevance 0.13
His medical history was significant for glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Negative_regulation (deficiency) of G6PD
3) Confidence 0.59 Published 2002 Journal Pharmacotherapy Section Abstract Doc Link 12013368 Disease Relevance 0.32 Pain Relevance 0.31
His medical history was significant for glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Negative_regulation (deficiency) of glucose-6-phosphate dehydrogenase
4) Confidence 0.59 Published 2002 Journal Pharmacotherapy Section Abstract Doc Link 12013368 Disease Relevance 0.32 Pain Relevance 0.32
A 35-year-old male with glucose-6-phosphate dehydrogenase (G6PD) deficiency was admitted because of right chest (pleuritic) pain, fever, cough with scarce production of blood-tinged sputum, and generalized yellowish discolouration of skin for 2 days.
Negative_regulation (deficiency) of G6PD in skin associated with pain, cough and fever
5) Confidence 0.59 Published 1997 Journal J. Infect. Section Abstract Doc Link 9459413 Disease Relevance 0.79 Pain Relevance 0.10
A 35-year-old male with glucose-6-phosphate dehydrogenase (G6PD) deficiency was admitted because of right chest (pleuritic) pain, fever, cough with scarce production of blood-tinged sputum, and generalized yellowish discolouration of skin for 2 days.
Negative_regulation (deficiency) of glucose-6-phosphate dehydrogenase in skin associated with pain, cough and fever
6) Confidence 0.59 Published 1997 Journal J. Infect. Section Abstract Doc Link 9459413 Disease Relevance 0.79 Pain Relevance 0.10
KPF-CoA was shown to induce the production of reactive oxygen species in Caco-2 cells, where its inhibition of G6PD activity was observed.
Negative_regulation (inhibition) of G6PD in Caco-2
7) Confidence 0.58 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17094951 Disease Relevance 0.15 Pain Relevance 0.14
Irreversible inhibition of glucose-6-phosphate dehydrogenase by the coenzyme A conjugate of ketoprofen: a key to oxidative stress induced by non-steroidal anti-inflammatory drugs?
Negative_regulation (inhibition) of glucose-6-phosphate dehydrogenase associated with stress, inflammation and cinod
8) Confidence 0.58 Published 2007 Journal Biochem. Pharmacol. Section Title Doc Link 17094951 Disease Relevance 0.29 Pain Relevance 0.35
Genotyping for MSP-1, MSP-2 and glucose-6-phosphate-dehydrogenase (G6PD) deficiency
Negative_regulation (deficiency) of glucose-6-phosphate-dehydrogenase
9) Confidence 0.57 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1995753 Disease Relevance 0.18 Pain Relevance 0
In individuals with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, aspirin at usual therapeutic doses is not a predisposing factor to hemolysis unless other risk factors are present.
Negative_regulation (deficiency) of glucose-6-phosphate dehydrogenase associated with aspirin and hemolysis
10) Confidence 0.57 Published 1986 Journal Drug Intell Clin Pharm Section Abstract Doc Link 3545733 Disease Relevance 1.16 Pain Relevance 0.56
[Use of the NSAID ketoprofen lysine salt in glucose-6-phosphate dehydrogenase (G6PD) deficiency in inflammatory disease in children].
Negative_regulation (deficiency) of G6PD associated with inflammation, cinod and disease
11) Confidence 0.57 Published 1996 Journal Pediatr Med Chir Section Title Doc Link 9064672 Disease Relevance 0.36 Pain Relevance 0.19
[Use of the NSAID ketoprofen lysine salt in glucose-6-phosphate dehydrogenase (G6PD) deficiency in inflammatory disease in children].
Negative_regulation (deficiency) of glucose-6-phosphate dehydrogenase associated with inflammation, cinod and disease
12) Confidence 0.57 Published 1996 Journal Pediatr Med Chir Section Title Doc Link 9064672 Disease Relevance 0.36 Pain Relevance 0.19
In addition, patients with G6PD deficiency may not produce sufficient NADPH to reduce methylene blue to leucomethylene blue; thus, methylene blue therapy may be ineffective in these patients [11].
Negative_regulation (deficiency) of G6PD
13) Confidence 0.47 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2829598 Disease Relevance 0.55 Pain Relevance 0.07
Glucose-6-phosphate dehydrogenase (G6PD) deficiency, a frequent congenital human enzyme defect, is the most frequent cause of hemolytic anemia triggered by drugs or infectious diseases.
Negative_regulation (deficiency) of Glucose-6-phosphate associated with communicable diseases and hemolytic anemia
14) Confidence 0.43 Published 2006 Journal Anaesthesist Section Abstract Doc Link 16485110 Disease Relevance 0.43 Pain Relevance 0.30
Drugs which induce acute hemolysis in patients with G6PD deficiency are often used in anesthesia and perioperative pain therapy.
Negative_regulation (deficiency) of G6PD associated with pain, anesthesia, hemolysis and perioperative pain
15) Confidence 0.43 Published 2006 Journal Anaesthesist Section Abstract Doc Link 16485110 Disease Relevance 0.48 Pain Relevance 0.35
[Anesthesia in patients with glucose-6-phosphate dehydrogenase deficiency: case report and perioperative anesthesiologic management].
Negative_regulation (deficiency) of glucose-6-phosphate associated with anesthesia
16) Confidence 0.43 Published 2006 Journal Anaesthesist Section Title Doc Link 16485110 Disease Relevance 0.44 Pain Relevance 0.45
Glucose-6-phosphate dehydrogenase (G6PD) deficiency, a frequent congenital human enzyme defect, is the most frequent cause of hemolytic anemia triggered by drugs or infectious diseases.
Negative_regulation (deficiency) of G6PD associated with communicable diseases and hemolytic anemia
17) Confidence 0.43 Published 2006 Journal Anaesthesist Section Abstract Doc Link 16485110 Disease Relevance 0.43 Pain Relevance 0.30
Pre-existing glucose-6-phosphate dehydrogenase (G6PD) deficiency as well as copper-induced inhibition of G6PD activity was documented during hospitalization.
Negative_regulation (deficiency) of G6PD
18) Confidence 0.43 Published 2004 Journal Vet Hum Toxicol Section Abstract Doc Link 15587250 Disease Relevance 1.35 Pain Relevance 0.13
Pre-existing glucose-6-phosphate dehydrogenase (G6PD) deficiency as well as copper-induced inhibition of G6PD activity was documented during hospitalization.
Negative_regulation (deficiency) of glucose-6-phosphate dehydrogenase
19) Confidence 0.43 Published 2004 Journal Vet Hum Toxicol Section Abstract Doc Link 15587250 Disease Relevance 1.37 Pain Relevance 0.13
There was no evidence of an association with hemolytic diseases, familial hyperlipidemia or Glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Negative_regulation (deficiency) of Glucose-6-phosphate dehydrogenase associated with hyperlipidemia and disease
20) Confidence 0.43 Published 1996 Journal Sao Paulo Med J Section Abstract Doc Link 9269102 Disease Relevance 0.58 Pain Relevance 0.10

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