INT36451

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Context Info
Confidence 0.75
First Reported 1988
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 7.20
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (G6PD) small molecule metabolic process (G6PD) oxidoreductase activity (G6PD)
carbohydrate metabolic process (G6PD) lipid metabolic process (G6PD) cytoplasm (G6PD)
Anatomy Link Frequency
gonad 4
liver 1
muscle 1
HeLa 1
G6PD (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 18 90.40 High High
Serotonin 4 88.76 High High
Locus ceruleus 1 82.68 Quite High
cINOD 27 80.32 Quite High
Paracetamol 4 76.84 Quite High
abdominal pain 2 67.96 Quite High
headache 9 66.80 Quite High
Osteoarthritis 1 66.24 Quite High
Pain 4 64.96 Quite High
Hippocampus 9 60.32 Quite High
Disease Link Frequency Relevance Heat
Natriuresis 1 100.00 Very High Very High Very High
Disease 152 98.96 Very High Very High Very High
Malaria 300 97.52 Very High Very High Very High
Hemolysis 9 88.08 High High
Methemoglobinemia 8 86.96 High High
Sickle Cell Anemia 16 85.04 High High
Stress 23 84.08 Quite High
Disorder Of Lipid Metabolism 1 83.36 Quite High
Vomiting 12 76.32 Quite High
Hypoxia 33 75.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the therapy increased the levels of alpha atrial natriuretic polypeptide (alpha ANP), beta endorphin, adrenocorticotropic hormone (ACTH), insulin and glucose-6-phosphate dehydrogenase (G-6-PDH), and it decreased the vasopression level.
Gene_expression (levels) of glucose-6-phosphate dehydrogenase associated with natriuresis
1) Confidence 0.75 Published 2004 Journal J. Radiat. Res. Section Abstract Doc Link 15133294 Disease Relevance 0.33 Pain Relevance 0.10
Pre-existing glucose-6-phosphate dehydrogenase (G6PD) deficiency as well as copper-induced inhibition of G6PD activity was documented during hospitalization.
Gene_expression (existing) of G6PD
2) Confidence 0.67 Published 2004 Journal Vet Hum Toxicol Section Abstract Doc Link 15587250 Disease Relevance 1.38 Pain Relevance 0.13
Pre-existing glucose-6-phosphate dehydrogenase (G6PD) deficiency as well as copper-induced inhibition of G6PD activity was documented during hospitalization.
Gene_expression (existing) of glucose-6-phosphate dehydrogenase
3) Confidence 0.67 Published 2004 Journal Vet Hum Toxicol Section Abstract Doc Link 15587250 Disease Relevance 1.38 Pain Relevance 0.13
The procedure was optimized to different TMAC washing temperatures for the different probes, reaching an optimum specificity of 62°C and 65°C for HbB and G6PD probes, respectively.
Gene_expression (probes) of G6PD
4) Confidence 0.66 Published 2005 Journal Malar J Section Body Doc Link PMC1326224 Disease Relevance 0 Pain Relevance 0
It was decreased in the presence of an allosteric inhibitor of G6PD, phospho(enol)pyruvate, and was not detected with G6PD of Leuconostoc mesenteroides, which does not possess the allosteric site.
Neg (not) Gene_expression (detected) of G6PD
5) Confidence 0.66 Published 2007 Journal Biochem. Pharmacol. Section Abstract Doc Link 17094951 Disease Relevance 0.21 Pain Relevance 0.27
However, glucose-6-phosphate dehydrogenase (G6PD) is needed to maintain NADH but is below 33% in AD [104].
Gene_expression (maintain) of glucose-6-phosphate dehydrogenase associated with disease
6) Confidence 0.65 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2876259 Disease Relevance 0.69 Pain Relevance 0.24
Our primary objectives were to determine the effect of SP+AS and SP+AS+PQ on submicroscopic P. falciparum gametocyte prevalence and density and to determine the safety of a single dose of PQ in glucose-6-phosphate-dehydrogenase (G6PD) deficient children.


Gene_expression (deficient) of glucose-6-phosphate-dehydrogenase
7) Confidence 0.58 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1995753 Disease Relevance 0.50 Pain Relevance 0.08
Although several countries adopted this recommendation, there is concern for negative haemolytic side effects in individuals who are glucose-6-phosphate-dehydrogenase (G6PD) deficient [1], [10].
Gene_expression (deficient) of glucose-6-phosphate-dehydrogenase
8) Confidence 0.58 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1995753 Disease Relevance 0.35 Pain Relevance 0
Using cluster analyses we classified 10.4% males to be G6PD deficient, while 18.4% had the functionally normal GdA+ enzyme.
Gene_expression (deficient) of G6PD
9) Confidence 0.44 Published 1988 Journal Blood Section Abstract Doc Link 3345344 Disease Relevance 0.52 Pain Relevance 0.06
In gonad (Fig. 2), the expression levels of 18S rRNA, rpl8, ef1a, g6pd, hprt1 and tbp were unaffected following exposure to EE2 in both males and females.
Gene_expression (expression) of g6pd in gonad
10) Confidence 0.25 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1802086 Disease Relevance 0 Pain Relevance 0
However, expression of ef1a, g6pd, and gapdh in liver was down-regulated following exposure to EE2 in both males and females (ef1a: to 32–41% of the control level; g6pd: to 15–23% of the control level; gapdh: to 4–6% of the control level) (Figs. 1C,D, and 1F).
Gene_expression (expression) of g6pd in liver
11) Confidence 0.25 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1802086 Disease Relevance 0 Pain Relevance 0
For example, ef1a and g6pd expression were only altered by EE2 in liver and not in gonad.
Gene_expression (expression) of g6pd in gonad
12) Confidence 0.25 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1802086 Disease Relevance 0 Pain Relevance 0
The effect of estrogen on gapdh and g6pd expression observed here likely results from their involvement in metabolism, since estrogens, like other sex steroids, are well known to have roles in the regulation of the metabolic processes associated with altered energy demands during gonad development and reproduction in fish [45-47].
Gene_expression (expression) of g6pd in gonad
13) Confidence 0.25 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1802086 Disease Relevance 0 Pain Relevance 0
In fact, estrogen-regulation of g6pd provides a likely explanation for differences we observed in hepatic g6pd expression between the sexes in this study (lower expression in females; data not shown), since female fish have higher circulating levels of endogenous estrogens than males.
Gene_expression (expression) of g6pd
14) Confidence 0.22 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1802086 Disease Relevance 0 Pain Relevance 0
Specifically, these genes comprised 18S rRNA, rpl8, ef1a, g6pd, bactin, gapdh, hprt1, and tbp.
Gene_expression (comprised) of g6pd
15) Confidence 0.22 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1802086 Disease Relevance 0 Pain Relevance 0
In particular, ef1a, g6pd, bactin, and gapdh were found to be strongly regulated by estrogen, and this is consistent with data published for other teleosts.
Gene_expression (found) of g6pd
16) Confidence 0.22 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1802086 Disease Relevance 0 Pain Relevance 0
Eight 'housekeeping' genes were selected for assessment, including 18S ribosomal RNA (18S rRNA), ribosomal protein l8 (rpl8), elongation factor 1 alpha (ef1a), glucose-6-phosphate dehydrogenase (g6pd), beta actin (bactin), glyceraldehyde-3-phosphate dehydrogenase (gapdh), hypoxanthine phosphoribosyltransferase 1 (hprt1), and tata box binding protein (tbp) in the fathead minnow (Pimephales promelas; a fish species widely used in ecotoxicology).
Gene_expression (assessment) of g6pd
17) Confidence 0.22 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1802086 Disease Relevance 0 Pain Relevance 0
Exposure to 10 ng/L EE2 for 21 days down-regulated the expression of ef1a, g6pd, bactin and gapdh in the liver, and bactin and gapdh in the gonad.
Gene_expression (expression) of g6pd in gonad
18) Confidence 0.20 Published 2007 Journal BMC Mol Biol Section Abstract Doc Link PMC1802086 Disease Relevance 0 Pain Relevance 0
HeLa cells show Type A G6PD and Type1 PGM profiling.
Gene_expression (profiling) of G6PD in HeLa
19) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698276 Disease Relevance 0.14 Pain Relevance 0
Although several countries adopted this recommendation, there is concern for negative haemolytic side effects in individuals who are glucose-6-phosphate-dehydrogenase (G6PD) deficient [1], [10].
Gene_expression (deficient) of G6PD
20) Confidence 0.20 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1995753 Disease Relevance 0.34 Pain Relevance 0

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