INT36453

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Context Info
Confidence 0.45
First Reported 1984
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 48
Total Number 50
Disease Relevance 19.90
Pain Relevance 10.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCA1) small molecule metabolic process (ABCA1) Golgi apparatus (ABCA1)
ATPase activity (ABCA1) plasma membrane (ABCA1) intracellular (ABCA1)
Anatomy Link Frequency
macrophages 5
plasma 3
liver 2
retina 1
brain 1
ABCA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 48 100.00 Very High Very High Very High
Paracetamol 6 100.00 Very High Very High Very High
Neurotransmitter 8 99.96 Very High Very High Very High
Adalimumab 6 99.84 Very High Very High Very High
adenocard 19 99.72 Very High Very High Very High
Neuropeptide 10 99.40 Very High Very High Very High
Regional anesthesia 1 99.30 Very High Very High Very High
alcohol 116 99.04 Very High Very High Very High
opioid receptor 88 98.90 Very High Very High Very High
Central nervous system 16 98.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 354 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 42 99.20 Very High Very High Very High
Cancer 270 98.88 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 58 98.18 Very High Very High Very High
Rheumatoid Arthritis 144 97.60 Very High Very High Very High
Breast Cancer 77 97.36 Very High Very High Very High
Nicotine Addiction 18 97.36 Very High Very High Very High
Age-related Macular Degeneration 387 97.08 Very High Very High Very High
Hypolipidemia 4 96.84 Very High Very High Very High
Lymphatic System Cancer 4 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The reverse cholesterol transport proteins cholesterol 27-hydroxylase and ATP-binding cassette transporter A1 (ABCA1) export cholesterol from macrophages.
ABCA1 Binding (binding) of in macrophages
1) Confidence 0.45 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860062 Disease Relevance 0.64 Pain Relevance 0.43
and immune complex-C1q complexes, diminish expression of both cholesterol 27-hydroxylase, an anti-atherogenic enzyme, and ATP-binding cassette transporter A1 (ABCA1), a protein that controls a cellular pathway for secretion of cholesterol for transport to the liver, in cells relevant to atherogenesis [10,11].
ABCA1 Binding (binding) of in liver associated with atherosclerosis
2) Confidence 0.45 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0.44 Pain Relevance 0.22
The reverse cholesterol transport proteins cholesterol 27-hydroxylase and ATP-binding cassette transporter A1 (ABCA1) export cholesterol from macrophages.
transporter A1 Binding (binding) of in macrophages
3) Confidence 0.39 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860062 Disease Relevance 0.64 Pain Relevance 0.43
and immune complex-C1q complexes, diminish expression of both cholesterol 27-hydroxylase, an anti-atherogenic enzyme, and ATP-binding cassette transporter A1 (ABCA1), a protein that controls a cellular pathway for secretion of cholesterol for transport to the liver, in cells relevant to atherogenesis [10,11].
transporter A1 Binding (binding) of in liver associated with atherosclerosis
4) Confidence 0.39 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0.44 Pain Relevance 0.22
Removal of cholesterol through a process known as reverse cholesterol transport requires the coordinated functioning of a number of genes including the P450 27-hydroxylase and the adenosine triphosphate-binding cassette transporter A1 (ABCA1).
ABCA1 Binding (binding) of associated with adenocard
5) Confidence 0.36 Published 2009 Journal J. Investig. Med. Section Abstract Doc Link 19289972 Disease Relevance 0.79 Pain Relevance 0.28
Removal of cholesterol through a process known as reverse cholesterol transport requires the coordinated functioning of a number of genes including the P450 27-hydroxylase and the adenosine triphosphate-binding cassette transporter A1 (ABCA1).
transporter A1 Binding (binding) of associated with adenocard
6) Confidence 0.31 Published 2009 Journal J. Investig. Med. Section Abstract Doc Link 19289972 Disease Relevance 0.79 Pain Relevance 0.28
ABCA1 transports cholesterol and phospholipids out of cells for pickup by Apo-A1 in the circulation.
ABCA1 Binding (phospholipids) of
7) Confidence 0.31 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 0.95 Pain Relevance 0
PPAR agonists have been postulated to increase macrophage cholesterol efflux through increased levels of ABCA1 and ABCG1.
ABCA1 Binding (levels) of in macrophage associated with agonist
8) Confidence 0.31 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835557 Disease Relevance 0.92 Pain Relevance 0.09
In all cases the protective effect of acetaminophen was attended with covalent binding of acetaminophen to membrane proteins.
membrane Binding (binding) of associated with paracetamol
9) Confidence 0.31 Published 1988 Journal Chem. Biol. Interact. Section Abstract Doc Link 3345571 Disease Relevance 0.16 Pain Relevance 0.53
In biological membranes, however, positively charged local anesthetics are better able to quench 1-anilinonaphthalene 8-sulfonate in protein regions, suggesting that the interaction between local anesthetics and membrane proteins can be electrostatic in nature.
membrane Binding (interaction) of associated with local anesthetic
10) Confidence 0.30 Published 1984 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6320881 Disease Relevance 0 Pain Relevance 0.66
Local anesthetics, once intercalated into the bilayer, may diffuse laterally and interact with membrane components, lipid as well as proteins.
membrane Binding (interact) of associated with local anesthetic
11) Confidence 0.30 Published 1984 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6320881 Disease Relevance 0 Pain Relevance 0.68
Since nitroxide free radicals are known to quench fluorophores upon 'contract', the results reflect the relative interaction of local anesthetics with membrane lipids and proteins.
membrane Binding (interaction) of associated with local anesthetic
12) Confidence 0.30 Published 1984 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6320881 Disease Relevance 0 Pain Relevance 0.66
Local anesthetics can interact electrostatically with membrane proteins.
membrane Binding (interact) of associated with local anesthetic
13) Confidence 0.30 Published 1984 Journal Biochim. Biophys. Acta Section Title Doc Link 6320881 Disease Relevance 0 Pain Relevance 0.53
ABCA1 = ATP-binding cassette transporter A1; CI = confidence interval; COX = cyclooxygenase; CT = threshold cycle; ECL = enhanced chemiluminescence; IFN-?
ABCA1 Binding (binding) of
14) Confidence 0.29 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0.42 Pain Relevance 0.19
ABCA1 = ATP-binding cassette transporter A1; CI = confidence interval; COX = cyclooxygenase; CT = threshold cycle; ECL = enhanced chemiluminescence; IFN-?
transporter A1 Binding (binding) of
15) Confidence 0.29 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0.43 Pain Relevance 0.19
However, it has been recently reported that ORP8 modulates expression levels of the cholesterol-efflux pump ATP-binding cassette A1 (ABCA1) in macrophages [43], and therefore it is possible that ORPs also contribute to the activity of LXRs by modulating cellular levels of LXR-target genes.
ABCA1 Binding (binding) of in macrophages
16) Confidence 0.26 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.16 Pain Relevance 0.03
However, it has been recently reported that ORP8 modulates expression levels of the cholesterol-efflux pump ATP-binding cassette A1 (ABCA1) in macrophages [43], and therefore it is possible that ORPs also contribute to the activity of LXRs by modulating cellular levels of LXR-target genes.
cassette A1 Binding (binding) of in macrophages
17) Confidence 0.26 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0.16 Pain Relevance 0.03
SR-BI mainly binds phospholipid-rich HDL particles, whereas ABCA1 preferably uses lipid-poor HDL particles as cholesterol acceptors [31].
ABCA1 Binding (binds) of associated with disorder of lipid metabolism
18) Confidence 0.22 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1215476 Disease Relevance 0.73 Pain Relevance 0
The adenosine triphosphate-binding cassette transporter A1 (ABCA1) plays a key role in HDL metabolism.
ABCA1 Binding (binding) of associated with adenocard and disorder of lipid metabolism
19) Confidence 0.19 Published 2009 Journal Metab. Clin. Exp. Section Abstract Doc Link 19059534 Disease Relevance 0.85 Pain Relevance 0.09
The adenosine triphosphate-binding cassette transporter A1 (ABCA1) plays a key role in HDL metabolism.
transporter A1 Binding (binding) of associated with adenocard and disorder of lipid metabolism
20) Confidence 0.17 Published 2009 Journal Metab. Clin. Exp. Section Abstract Doc Link 19059534 Disease Relevance 0.85 Pain Relevance 0.09

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