INT3647

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.41
First Reported 1976
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 20
Total Number 22
Disease Relevance 15.71
Pain Relevance 5.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (F13A1) transferase activity, transferring acyl groups (F13A1) cytoplasm (F13A1)
Anatomy Link Frequency
platelets 7
coronary artery 5
plasma 3
blood 3
liver 2
F13A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 8 100.00 Very High Very High Very High
Inflammation 38 99.92 Very High Very High Very High
Pain 20 99.68 Very High Very High Very High
Nerve growth factor 14 99.20 Very High Very High Very High
Angina 22 99.00 Very High Very High Very High
Arthritis 37 97.20 Very High Very High Very High
abdominal pain 2 97.00 Very High Very High Very High
headache 1 95.88 Very High Very High Very High
aspirin 8 93.28 High High
anesthesia 1 92.84 High High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 33 100.00 Very High Very High Very High
Sickle Cell Anemia 12 100.00 Very High Very High Very High
Thrombosis 7 100.00 Very High Very High Very High
Pancreatitis 2 100.00 Very High Very High Very High
Fistula 1 100.00 Very High Very High Very High
INFLAMMATION 43 99.92 Very High Very High Very High
Thrombocytopenia 1 99.18 Very High Very High Very High
Cv General 3 Under Development 19 99.00 Very High Very High Very High
Acidosis 1 98.96 Very High Very High Very High
Thrombophilia 4 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As the use of the balloon has often been associated with a reduction in the number of circulating platelets and a pathological increase in the breakdow products of fibrin, heparin is now used systematically in an attempt to prevent the development of a true intravascular coagulation syndrome.
Positive_regulation (increase) of Gene_expression (products) of fibrin in platelets associated with syndrome and disseminated intravascular coagulation
1) Confidence 0.41 Published 1976 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 821419 Disease Relevance 0.53 Pain Relevance 0.13
These findings include the nephrotic syndrome, great variability in proteinuria and glomerular filtration rate, pulmonary embolization, sterile pyuria, hematuria, hyperchloremic acidosis, decreased renal tubular threshold for glucose and increased fibrin degradation products.
Positive_regulation (increased) of Gene_expression (products) of fibrin associated with acidosis, pyuria, proteinuria, hematuria and disorder of lipid metabolism
2) Confidence 0.40 Published 1977 Journal Am. J. Med. Section Abstract Doc Link 900143 Disease Relevance 0.73 Pain Relevance 0
CLINICAL RELEVANCE: The alveolar macrophage has a key role in fibrin production.
Positive_regulation (role) of Gene_expression (production) of fibrin in alveolar macrophage
3) Confidence 0.38 Published 1996 Journal Am. J. Vet. Res. Section Body Doc Link 8723878 Disease Relevance 0 Pain Relevance 0
However, our study showed, for the first time, that LPS increases TF(+) monocytes, substantially decreases FVIIa levels, and enhances plasma levels of thrombus precursor protein, which may be a useful marker of fibrin formation in humans.
Positive_regulation (enhances) of Gene_expression (formation) of fibrin in plasma associated with thrombosis
4) Confidence 0.20 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 10521382 Disease Relevance 0.19 Pain Relevance 0.43
[Endoscopic fibrin gluing of a pancreatic duct fistula following acute pancreatitis].
Positive_regulation (pancreatitis) of Gene_expression (gluing) of fibrin in pancreatic duct associated with fistula and pancreatitis
5) Confidence 0.13 Published 1996 Journal Dtsch. Med. Wochenschr. Section Title Doc Link 8964229 Disease Relevance 0.49 Pain Relevance 0.28
Coagulation profile revealed decreased platelets, plasma coagulation factors and fibrinogen in association with elevated fibrin degradation products.
Positive_regulation (elevated) of Gene_expression (products) of fibrin in platelets
6) Confidence 0.10 Published 1999 Journal Anaesth Intensive Care Section Abstract Doc Link 10389563 Disease Relevance 0.51 Pain Relevance 0.17
It is concluded that increased thrombin activity and fibrin formation are features of steady-state sickle cell disease, and that they further increase during painful crisis.
Positive_regulation (increased) of Gene_expression (formation) of fibrin associated with sickle cell anemia and pain
7) Confidence 0.05 Published 1989 Journal Haemostasis Section Abstract Doc Link 2731776 Disease Relevance 0.59 Pain Relevance 0.50
It is concluded that increased thrombin activity and fibrin formation are features of steady-state sickle cell disease, and that they further increase during painful crisis.
Positive_regulation (increase) of Gene_expression (formation) of fibrin associated with sickle cell anemia and pain
8) Confidence 0.05 Published 1989 Journal Haemostasis Section Abstract Doc Link 2731776 Disease Relevance 0.58 Pain Relevance 0.50
Increased fibrinogen and fibrin deposition within joints are prominent indicators of active SJIA flare [46] and arthritis [47].
Positive_regulation (Increased) of Gene_expression (deposition) of fibrin in joints associated with arthritis
9) Confidence 0.05 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.85 Pain Relevance 0.17
Mildly elevated levels of fibrin split products were seen after TNF treatment in 5/13 evaluable patients and one ineligible patient.
Positive_regulation (after) of Gene_expression (products) of fibrin
10) Confidence 0.04 Published 1990 Journal J Biol Response Mod Section Abstract Doc Link 2074444 Disease Relevance 1.42 Pain Relevance 0.10
Coagulation profile revealed decreased platelets, plasma coagulation factors and fibrinogen in association with elevated fibrin degradation products.
Positive_regulation (elevated) of in plasma Gene_expression (products) of fibrin in platelets
11) Confidence 0.03 Published 1999 Journal Anaesth Intensive Care Section Abstract Doc Link 10389563 Disease Relevance 0.51 Pain Relevance 0.17
Hematologic manifestations consisted of leukocytosis with a left shift, thrombocytopenia, prolonged partial thromboplastin time, increased fibrin degradation products, and positive protamine sulfate test.
Spec (partial) Positive_regulation (increased) of Gene_expression (products) of fibrin associated with leukocytosis and thrombocytopenia
12) Confidence 0.02 Published 1981 Journal Clin. Toxicol. Section Abstract Doc Link 7237964 Disease Relevance 1.67 Pain Relevance 0.08
It enhances fibrin production on the liver surface and induces adhesions [11].
Positive_regulation (enhances) of Gene_expression (production) of fibrin in liver associated with adhesions
13) Confidence 0.02 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2667516 Disease Relevance 1.38 Pain Relevance 0.10
Exercise-induced myocardial ischemia in patients with coronary artery disease: lack of evidence for platelet activation or fibrin formation in peripheral venous blood.
Positive_regulation (activation) of Gene_expression (formation) of fibrin in blood associated with coronary artery disease and ischemia
14) Confidence 0.02 Published 1983 Journal J. Am. Coll. Cardiol. Section Title Doc Link 6339591 Disease Relevance 0.60 Pain Relevance 0.13
Exercise-induced myocardial ischemia in patients with coronary artery disease: lack of evidence for platelet activation or fibrin formation in peripheral venous blood.
Positive_regulation (Exercise-induced) of in coronary artery Gene_expression (formation) of fibrin in blood associated with coronary artery disease and ischemia
15) Confidence 0.02 Published 1983 Journal J. Am. Coll. Cardiol. Section Title Doc Link 6339591 Disease Relevance 0.60 Pain Relevance 0.13
Coagulation parameters such as prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen concentration, platelet count, fibrin monomers, D-dimers, antithrombin III and factor XIII activities, thrombelastography, and platelet aggregometry were measured during a 4-h period after sequential double endotoxin administration (80 and 40 micrograms/kg of body weight, intravenously).
Spec (partial) Positive_regulation (activated) of Gene_expression (activities) of fibrin in body associated with body weight
16) Confidence 0.01 Published 1995 Journal Lab. Anim. Sci. Section Abstract Doc Link 8569153 Disease Relevance 0.33 Pain Relevance 0.09
Tissue factor emerges as the initial mechanism leading to thrombin generation and fibrin formation to stabilize the platelet-rich thrombus.
Positive_regulation (leading) of Gene_expression (generation) of fibrin in platelet associated with thrombosis
17) Confidence 0.01 Published 2004 Journal Rev Clin Esp Section Abstract Doc Link 15104934 Disease Relevance 0.87 Pain Relevance 0.17
Increased levels of fibrin D-dimer are indicative of a hypercoagulable state, as found in acute coronary syndromes.
Positive_regulation (Increased) of Gene_expression (levels) of fibrin associated with acute coronary syndrome and thrombophilia
18) Confidence 0.01 Published 2001 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 11597948 Disease Relevance 0.64 Pain Relevance 0.10
Furthermore, fibrin production was increased at 3 and 5 h after NGF administration.
Positive_regulation (increased) of Gene_expression (production) of fibrin associated with nerve growth factor
19) Confidence 0.01 Published 2002 Journal J. Pathol. Section Abstract Doc Link 12015750 Disease Relevance 0.61 Pain Relevance 0.68
Does exercise-induced myocardial ischaemia cause enhanced platelet activation and fibrin formation in patients with stable angina and severe coronary artery disease?
Positive_regulation (activation) of Gene_expression (formation) of fibrin in coronary artery associated with angina and coronary artery disease
20) Confidence 0.01 Published 1987 Journal Eur. Heart J. Section Title Doc Link 2958280 Disease Relevance 1.15 Pain Relevance 0.50

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox