INT36488

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Context Info
Confidence 0.39
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 1.18
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (MMD)
Anatomy Link Frequency
MMA 6
MCA 1
lateral 1
neurons 1
MMD (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 1 99.56 Very High Very High Very High
Thalamus 8 98.92 Very High Very High Very High
primary afferent fibers 4 98.12 Very High Very High Very High
medulla 4 93.80 High High
Intracerebroventricular 1 68.64 Quite High
Sumatriptan 2 50.00 Quite Low
Pain 7 47.60 Quite Low
nociceptor 1 25.00 Low Low
headache 7 10.00 Low Low
Calcitonin gene-related peptide 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malaria 84 99.58 Very High Very High Very High
Headache 7 93.32 High High
Increased Venous Pressure Under Development 2 92.80 High High
Drug Induced Neurotoxicity 1 87.92 High High
Convulsion 3 77.52 Quite High
Targeted Disruption 4 75.00 Quite High
Nociception 7 70.40 Quite High
Asymptomatic Infections 4 50.00 Quite Low
Fever 10 48.64 Quite Low
Toxicity 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, neuronal responses to stimulation of the MMA and SS were sought in the thalamus of the cat.
Positive_regulation (stimulation) of MMA in MMA associated with thalamus
1) Confidence 0.39 Published 1988 Journal Brain Res. Section Abstract Doc Link 3409027 Disease Relevance 0 Pain Relevance 0.17
Most neurons (48/61) responded to electrical stimulation of the MMA or SS with a burst of 2-5 spikes.
Positive_regulation (stimulation) of MMA in neurons
2) Confidence 0.39 Published 1988 Journal Brain Res. Section Abstract Doc Link 3409027 Disease Relevance 0.06 Pain Relevance 0.17
Sixty-one neurons excited by electrical stimulation of the MMA and/or SS were located in the ventroposteromedial (VPM) nucleus, and surrounding regions in lateral thalamus.
Positive_regulation (stimulation) of MMA in lateral associated with thalamus
3) Confidence 0.39 Published 1988 Journal Brain Res. Section Abstract Doc Link 3409027 Disease Relevance 0 Pain Relevance 0.18
Mechanical stimulation of the MMA and SS was also an effective stimulus and in some cases evoked a burst response.
Positive_regulation (stimulation) of MMA in MMA
4) Confidence 0.39 Published 1988 Journal Brain Res. Section Abstract Doc Link 3409027 Disease Relevance 0.07 Pain Relevance 0.16
We recorded circumference changes of the middle meningeal artery (MMA) and middle cerebral artery (MCA) using magnetic resonance angiography before and after infusion (20 minutes) of 1.5 ?
Positive_regulation (middle) of MMA in MCA
5) Confidence 0.33 Published 2010 Journal Neurology Section Body Doc Link 20975053 Disease Relevance 0.19 Pain Relevance 0
The mean minimum latencies to suprathreshold electrical stimulation of the MMA and the SS were similar for Vc and Vo/Vi neurons.
Positive_regulation (stimulation) of MMA in MMA
6) Confidence 0.28 Published 1988 Journal J. Neurophysiol. Section Abstract Doc Link 3351579 Disease Relevance 0 Pain Relevance 0
In the first period, children harbouring P. falciparum had a five-fold increased risk to develop a MMA during the nine following days, independently of their age.
Positive_regulation (increased) of MMA in MMA
7) Confidence 0.23 Published 2008 Journal Malar J Section Body Doc Link PMC2567330 Disease Relevance 0.22 Pain Relevance 0
Plasmodium falciparum ACs had a five-fold increased risk of MMA compared to non carriers (RR = 5.32, IC = [1.56–18.16], p = 0.008) (Table 2).
Positive_regulation (increased) of MMA in MMA associated with malaria
8) Confidence 0.23 Published 2008 Journal Malar J Section Body Doc Link PMC2567330 Disease Relevance 0.27 Pain Relevance 0
The Medicare Part D prescription drug benefit offers beneficiaries the promise of coverage for increasingly expensive medications, when many have lacked such coverage in the past.2 Overall, the implementation of this program has the potential to improve the access of many beneficiaries to their prescription medications.7–10,15 Although cost may not be the only consideration for beneficiaries as they select their PDPs, high prescription drug costs were a major motivation for the MMA7,8 and we expect that many beneficiaries heavily weigh the anticipated cost of a PDP in their decision-making process.
Positive_regulation (motivation) of MMA7
9) Confidence 0.12 Published 2007 Journal J Gen Intern Med Section Body Doc Link PMC1824717 Disease Relevance 0 Pain Relevance 0
Methylmalonic acidemias consist of a group of inherited neurometabolic disorders caused by deficiency of methylmalonyl-CoA mutase activity clinically and biochemically characterized by neurological dysfunction, methylmalonic acid (MMA) accumulation, mitochondrial failure and increased reactive species production.
Positive_regulation (accumulation) of MMA in MMA associated with anesthesia
10) Confidence 0.03 Published 2009 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 19073247 Disease Relevance 0.38 Pain Relevance 0.13

General Comments

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